1.An Unusual Case of Metastatic Adenocarcinoma on the Scrotum with Swelling Originating from Gastric Cancer.
Won Joo KWON ; Min Seok KIM ; Yosub SHIN ; Eun Byul CHO ; Eun Joo PARK ; Kwang Ho KIM ; Kwang Joong KIM
Korean Journal of Dermatology 2017;55(4):264-282
No abstract available.
Adenocarcinoma*
;
Scrotum*
;
Stomach Neoplasms*
2.The relationship between serum adiponectin and inflammatory cytokines in obese Korean juveniles.
Sung Hwan BYUN ; Eun Byul KWON ; Se Young KIM
Korean Journal of Pediatrics 2014;57(12):533-537
PURPOSE: Obesity is related to systemic inflammatory processes causing cardiovascular complications. Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), P-selectin are newly described mediators of inflammation and have a significant effect in atherosclerosis. Adiponectin has shown anti-inflammatory effects in adults. The aim of this study was to evaluate the relationship between adiponectin and inflammatory mediators in children and adolescents. METHODS: Fifty children or adolescents, twenty two with a body mass index (BMI) over 95th percentile, and twenty eight with a BMI below 75th percentile were included in the study. Serum soluble ICAM-1 (sICAM-1), P-selectin, CD40L, lipid profiles, aspartate aminotransferase, alanine aminotransferase, glucose and insulin were measured to evaluate associations with adiponectin. Comparison of these variables was performed between the obese and the nonobese group. RESULTS: We found a adiponectin to be significant lower and sICAM-1 significant higher in the obese group compared to the nonobese group, but there were no significant differences in P-selectin and soluble CD40L. Adiponectin was negatively associated with ICAM-1 and P-selectin in the obese group. CONCLUSION: Negative associations of adiponectin with ICAM-1 and P-selectin in obese children and adolescents suggest that serum adiponectin level may represent the inflammatory status.
Adiponectin*
;
Adolescent
;
Adult
;
Alanine Transaminase
;
Aspartate Aminotransferases
;
Atherosclerosis
;
Body Mass Index
;
CD40 Ligand
;
Child
;
Cytokines*
;
Glucose
;
Humans
;
Inflammation Mediators
;
Insulin
;
Intercellular Adhesion Molecule-1
;
Obesity
;
P-Selectin
3.Delayed diagnosis of 22q11 deletion syndrome due to late onset hypocalcemia in a 11-year-old girl with imperforated anus.
Dong Yoon YOO ; Hae Jung KIM ; Kee Hyun CHO ; Eun Byul KWON ; Eun Gyong YOO
Annals of Pediatric Endocrinology & Metabolism 2017;22(2):133-138
Neonatal hypocalcemia and congenital heart defects has been known as the first clinical manifestation of the chromosome 22q11.2 deletion syndrome (22q11DS). However, because of its wide clinical spectrum, diagnosis of 22q11DS can be delayed in children without classic symptoms. We report the case of a girl with the history of imperforate anus but without neonatal hypocalcemia or major cardiac anomaly, who was diagnosed for 22q11DS at the age of 11 after the onset of overt hypocalcemia. She was born uneventfully from phenotypically normal Korean parents. Imperforate anus and partial cleft palate were found at birth, which were surgically repaired thereafter. There was no history of neonatal hypocalcemia, and karyotyping by GTG banding was normal. At the age of 11, hypocalcemia (serum calcium, 5.0 mg/dL) and decreased parathyroid hormone level (10.8 pg/mL) was noted when she visited our Emergency Department for fever and vomiting. The 22q11DS was suspected because of her mild mental retardation and velopharyngeal insufficiency, and a microdeletion on chromosome 22q11.2 was confirmed by fluorescence in situ hybridization. The 22q11DS should be considered in the differential diagnosis of hypocalcemia at any age because of its wide clinical spectrum.
22q11 Deletion Syndrome*
;
Anal Canal*
;
Anus, Imperforate
;
Calcium
;
Child*
;
Cleft Palate
;
Delayed Diagnosis*
;
Diagnosis
;
Diagnosis, Differential
;
DiGeorge Syndrome
;
Emergency Service, Hospital
;
Female*
;
Fever
;
Fluorescence
;
Heart Defects, Congenital
;
Humans
;
Hypocalcemia*
;
Hypoparathyroidism
;
In Situ Hybridization
;
Intellectual Disability
;
Karyotyping
;
Parathyroid Hormone
;
Parents
;
Parturition
;
Velopharyngeal Insufficiency
;
Vomiting
4.Three Cases of Lichen Nitidus Associated with Various Cutaneous Diseases.
Eun Byul CHO ; Heung Yeol KIM ; Eun Joo PARK ; In Ho KWON ; Kwang Ho KIM ; Kwang Joong KIM
Annals of Dermatology 2014;26(4):505-509
Lichen nitidus (LN) is an uncommon, usually asymptomatic cutaneous eruption characterized by the presence of multiple, small, flesh-colored papules. The epidemiologic and pathophysiologic characteristics of LN have not yet been defined. Furthermore, LN has rarely been described in association with other cutaneous diseases. We herein report 3 cases of LN associated with various cutaneous diseases, including lichen striatus, oral lichen planus, and psoriasis vulgaris.
Lichen Nitidus*
;
Lichen Planus
;
Lichen Planus, Oral
;
Lichens
;
Mouth
;
Psoriasis
5.Fluoroscopy-induced Chronic Radiation Dermatitis.
Eun Byul CHO ; Byong Han SONG ; Eun Joo PARK ; In Ho KWON ; Kwang Ho KIM ; Kwang Joong KIM
Korean Journal of Dermatology 2012;50(7):614-617
Fluoroscopy-induced chronic radiation dermatitis (FICRD) is a cutaneous disorder that results from prolonged exposure to ionizing radiation during interventional procedures. With the expanded use of interventional procedures, there is increased fluoroscopic exposure. However, diagnosis and treatment of such disorder remain difficult. Herein, we report on a case of FICRD that occurred in the right subscapular area.
Angioplasty, Balloon, Coronary
;
Dermatitis
;
Radiation, Ionizing
6.Balloon Cell Melanoma.
Byong Han SONG ; Eun Byul CHO ; Eun Joo PARK ; In Ho KWON ; Kwang Ho KIM ; Kwang Joong KIM
Korean Journal of Dermatology 2012;50(3):252-254
Balloon cell melanoma, an uncommon histopathological variant of malignant melanoma, was first described by Gardner and Vazquez in 1970. This condition is histopathologically characterized by the presence of balloon cells with varying sizes and atypical nuclei. An 84-year-old woman presented with a solitary, dome-shaped, walnut-sized, brownish nodule on the posterior aspect of the left ear with bleeding, having only detected the nodule 2 weeks prior. Histopathologically, the lobulated tumor mass revealed copious melanin pigment and many balloon cells with clear cytoplasm, atypical nuclei, and variable size. Immunohistochemically, the tumor mass showed positive reaction to S-100 protein and HMB 45 staining. We herein report a typical case of balloon cell melanoma, which developed primarily on the skin.
Aged, 80 and over
;
Cytoplasm
;
Ear
;
Female
;
Hemorrhage
;
Humans
;
Melanins
;
Melanoma
;
S100 Proteins
;
Skin
7.Transient Zinc Deficiency Located on Unusual Sites.
Byung Chul KIM ; Eun Byul CHO ; Eun Joo PARK ; In Ho KWON ; Kwang Ho KIM ; Kwang Joong KIM
Korean Journal of Dermatology 2011;49(6):529-532
Zinc deficiency in breast-fed infants is an important disorder. Unlike acrodermatitis enteropathica, it is transient and stops when nursing ends. We report on a case of a breast-fed, full-term male infant who presented with erythematous fine scaly patches and plaques involving the flexural area and trunk at 4 month of age. Clinical impressions of intertrigo, fungal infection or inverse psoriasis were considered. These lesions did not respond to treatment with topical antifungal agents and corticosteroids. The results of laboratory investigations revealed a lowered zinc level in the infant's serum (48.4microg/dl: normal 70~121microg/dl) and in the mother's milk (16microg/dl: normal 48~75microg/dl) and a normal level of zinc in the mother's serum. After the patient's mother was given zinc supplements, the skin lesions were dramatically improved and his serum zinc level became normal. Early recognition of the disorder and introduction of zinc supplementation rapidly reversed the transient zinc deficiency.
Acrodermatitis
;
Adrenal Cortex Hormones
;
Antifungal Agents
;
Humans
;
Infant
;
Intertrigo
;
Male
;
Milk
;
Mothers
;
Psoriasis
;
Skin
;
Zinc
8.Primary Cutaneous Adenoid Cystic Carcinoma of the Knee in a Young Male.
Eun Byul CHO ; Sang Hyeon KU ; Min Kyung LEE ; Gyeong hun PARK ; Eun Joo PARK ; In Ho KWON ; Kwang Ho KIM ; Kwang Joong KIM
Korean Journal of Dermatology 2014;52(6):432-434
No abstract available.
Carcinoma, Adenoid Cystic*
;
Humans
;
Knee*
;
Male
9.The triglyceride-to-high density lipoprotein cholesterol ratio in overweight Korean children and adolescents.
Dong Yoon YOO ; Yu Sun KANG ; Eun Byul KWON ; Eun Gyong YOO
Annals of Pediatric Endocrinology & Metabolism 2017;22(3):158-163
PURPOSE: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents. METHODS: Data from 255 overweight (aged 8.7±2.0 years) and 514 normal weight (aged 8.9±1.8 years) children and adolescents were evaluated. Glucose, insulin, total cholesterol (TC), HDL-C and TG levels were measured after overnight fasting, and the TG/HDL-C ratio, non–HDL-C and the homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. RESULTS: The TG/HDL-C ratio was higher in overweight group compared to normal weight group (P < 0.001). Among overweight children and adolescents, alanine aminotransferase (P=0.018), non–HDL-C (P < 0.001), and HOMA-IR (P=0.004) were different between the TG/HDL-C ratio tertile groups. The prevalence of elevated HOMA-IR was increased with increasing TG/HDL-C ratio tertiles (P for trend=0.003). On regression analysis adjusted for age and sex, the BMI (β=0.402, P=0.001) and TG/HDL-C ratio (β=0.251, P=0.014) were independently associated with HOMA-IR (adjusted R2=0.324). The TG/HDL-C ratio of 2.0 or more showed higher sensitivity (55.6%) and specificity (72.9%), when compared to TC (≥200 mg/dL), non–HDL-C (≥145 mg/dL), and LDL-C (≥130 mg/dL) for identifying overweight children with elevated HOMA-IR. CONCLUSION: The TG/HDL-C ratio is independently associated with insulin resistance in overweight children and adolescents, and it can be useful in identifying those at higher cardiometabolic risk.
Adolescent*
;
Alanine Transaminase
;
Child*
;
Cholesterol*
;
Dyslipidemias
;
Fasting
;
Glucose
;
Homeostasis
;
Humans
;
Hypertriglyceridemia
;
Insulin
;
Insulin Resistance
;
Lipoproteins*
;
Obesity
;
Overweight*
;
Prevalence
;
Sensitivity and Specificity