BACKGROUND: The occurane of sarcoidosis seems to be increased recently. A proportion of patients initiallly visit the derrnatological department. However, there are few clinical reports about sarcoidosis for the dermatolagist. OBJECTIVE: This study wa performed to find the clinical and histopathological characteristis of sarcoidosis as a multisystemic disease. METHODS: We reviwed the chart of patients with sarcoidosis who were diagnosed at SNUH from 1984 to 1994 and analysed the characteristics of the clinical and histopathologic findings according to several factors. RESULTS: 1)Man to woman ratio was 1: 2 and 70% of patients were in theirs third to fifth decades. 2)The main complaints were respiratory symtoms and cutaneous lesion. 3)The most frequently invloved organ was intrathoracic, followed by skin, peripheral lymph node, eye and bone in that order. 4)The cutaneous lesion was found in 50% of patients(15 out of 30) and specitic lesions were present in 14 cases. A subcitaneous nodule was the most common lesion(67%). 5)In subcutaenous sarcoicosis, there was hilar lymphadenopathy in 70% of the patients, lung parenchymal infiltration in 10%, peripheral lymphadenopathy in 30%, bony lesion in 30%. 6)The laboratory and histopathological findings were similar to previously reported results. CONCLUSION: The general features of patients were similar to other reports except for the fre quency of cutaneous involviment. Cutaneous involvement was found in 50% of patients and this was higher than in foreigr reports. In cutaneous sarcoidosis, the subcutaneous nodule was the most frequent specific lesior.
Female ; Humans ; Lung ; Lymph Nodes ; Lymphatic Diseases ; Sarcoidosis* ; Skin

No abstract available.
Adrenal Cortex Hormones*

The clinical, gross, light microscopic and immunohistochemical findings of three cases of blue nevus of the uterine endocervix were described. All three cases were incidentally found in hysterectomy specimens from middle-aged women, 45 to 48 years of age. The lesions were small and measured 1 to 4 mm in the greatest diameter. The presence of elongated, somewhat wavy and dendritic melanin-containing cells, in clusters or scattered deep in the subepithelial stroma and between the endocervical glands, was the distinct feature. The cytoplasmic granules appeared black with Grimelius and Fontana-Masson stains. The cells showed strong positive reaction with S-100 protein in perinuclear cytoplasm, in addition to the diffusely dispersed melanin granules. The demonstration of S-100 protein in the blue nevus, along with the histochemical findings, supports combined melanocytic and schwannian differentiation of the blue nevus cells.
Female ; Humans

No abstract available.
Cholangitis*

BACKGROUND: The action of ultraviolet rays on DNA causes the main photobiologic response of cells to ultraviolet rays. To study this effect, tritiated thymidine autoradiography was used. Recently 5-bromo-2deoxyuridine(BrdU), an analogue of thymidine, immunohistochemistry has been developed and is used in the detection of synthetic phase cells. Compared to autoradiography, there are several advantages of BrdU immunohistochemistry; a shorter processing time, no requirement of specific facilites. PUVA, the combination method of UVA and Psoralen has lots of photobiologic effects. OBJECTIVE: Using Brdu immunohistochemistry, the effect of PUVA on the DNA synthesis of tape stripped mouse epdermis was studied. METHOD: Mice stripped by adhesive tape for enhancing DNA synthesis were injected intraperitoneally with 50mg/kg of BrdU immediately after stripping and at 6, 12, 14, 16, 18, 20, 22, 24 and 48 hours after tape stripping for decision of the time for PUVA. The skin diopsies were taken and the specimens were stained by BrdU immunohistochemistry. Single systemic PUVA exposure was performed on the stripped epidermis in peak synthetic time after tape stripping. The irradiation dose of UVA was 5J/cm(2). 8-MOP was administered at 90 minutes before UVA irradiation via a feeding tube with the dose of 16mg/kg. Mice were injected intraperitoneally with 50mg/kg of BrdU immediately after PUVA and at 12, 24, 48, 72 hours, and 7 days after PUVA. The skin biopsies were taken and the specimens were stained by BrdU immunohistochemistry. Positively labeled cells were counted per 5mm epidermis. RESULT: The results can be summerized as follows : 1. The mean numbers of BrdU labeled cells of each groups according to time after tape stripping were 11.0+/-4.4 at immediate, 24.0+/-9.7 at 6 hours 31.4+/-18.1 at 12 hours, 55.0+/-16.1 at 14 hors, 25.8+/-9.7 at 16 hors, 44.2+/-15.7 at 18 hors, 47.6+/-15.6 at 20 hors, 33.4+/-12.3 at 22 hors, 38.0+/-16.3 at 24 hors, and 22.0+/-8.2 at 48 hors group. The mean number of BrdU labeled cells was observed at 14 hors after tape stripping (p<0.05). So by tape stripping DNA synthesis was enhanced maximally at 14 hours after tape stripping. 2. The man numbers of BrdU labeled cells of each groups according to time after PUVA were 11.0+/-7.5 at immediate, 32.2+/-13.2 at immediate, 32.2+/-13.2 at 6hors, 26.4+/-13.4 at 24 hours, 18.0+/-3.4 at 48 hours, 40.3+/-8.3 at 72 hours, and 27.8+/-11.0 at 7 days group. The lowest number of BrdU labeled cells was observed immediately after PUVA(p<0.05). The decreasein the number of BrdU labeled cells significantly persisted 48 hours after PUVA(p<0.05). CONCLUSION: The inhibitory effect on DNA synthesis of PUVA might be sustained 48 hours after PUVA. DNA synthesis was recovered at 72 hours after PUVA and sustained for 7 days.
Adhesives ; Animals ; Autoradiography ; Biopsy ; Bromodeoxyuridine ; DNA* ; Epidermis ; Ficusin ; Immunohistochemistry* ; Methoxsalen ; Mice ; Skin ; Thymidine ; Ultraviolet Rays

No abstract available.
Jaundice*

No abstract available.
Thyroid Gland* ; Thyroid Nodule*

No abstract available.
Gastrectomy* ; Stomach Neoplasms*

No abstract available.
Acute Kidney Injury*

No abstract available.
Liver Abscess* ; Liver*