No abstract available.
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Rats ; Submandibular Gland

No abstract available.
Adult* ; Animals ; Dogs* ; Humans ; Mandible*

No abstract available.
Odontogenic Tumors*

No abstract available.
Replantation*

No abstract available.
Carcinoma, Squamous Cell* ; Leukoplakia* ; Papilloma*

No abstract available.
Ameloblastoma

Cancer chemoprevention can be defined as prevention or intervantion of cancer by the administration of one or chemical entities, either, either as individual drugs or as naturally occurring constituents of the diet. The name capsaicin(trans-8-methyl-N-vanillyl-6-nonenamide) was given by Thresh in 1848, and capsaicin is a primary pungent and irritating princple present in red peppers which are windely used as spices in korean food. The inhibitory effect of capsacin on stomach or skin cancers had been reported in lots of animal studies, but there were few reports In offal cancer carclnogenesls. This study is aimed to see the effect of capsalcln upon DMBA induced cancer of the buccal pouch in hamsters. In thls study, 87 Golden Syrian hamsters, weighing about 80-90g, were used and divided into 5 group : normal group (n=2)-untreated : control group(n=15)-DMBA painted : experimental group I(n=23)-capsaicin(10 micromol/2ml) and DMBA painted ; experimental groupII(n=23)-capsaicin administered and DMBA painted ; experimental group III(n=24)-administered and patinted. DMBA painted. According to groups, the animals were sacrificed at 5, 8, 11, 14, 17 week. Microscopic examination was done and BrdUrd labeling Index was calculated. The results are as follows : 1. According to gross examination, the leukoplakia at 5 week and the papilloma at 8 week were shown in the experimental group I, III. Those feature were appeased rapider than those of the control and expefimental group II. 2. According to gross examination, the exophytic tumorous lesions were shown in the control and all of the experimental groups from 14week, but the features of the control group were severer than those of the experimental groups. 3. According to histopathologic features, the papilloma was shown in all of the experimental group except the control group at 8 week 4. Histologically, the features of the control group were severer than those of the experimental groups from 14 week and there were similar features among the experimental group I, II, III at 17 week 5. At 8 week, BrdUrd labeling index of experimental group I, III were than that of control group and it was statistically significant (p<0.05) 6. The BrdUrd labeling index of experimental group III from 11week, experimental group I from 14week, experimental group II from 17 week were lowed than that of the control group respectively and It was statistically significant(p<0.05) 7. In the distribution of the BrdUrd labeled cells, BrdUrd was more significant in the basal and parabasal cell in dysplatic changes, but in carcinoma in situ, BrdUrd showed a irregular arrangement throughout the whole thickness of the tumor epithelium According to the abone results, the irritating property of the capsaicin accelerated the carcinogenesis in early phase, but the inhibitory effect was shown from carcinoma in situ phase. So the chemopreventive effect of the capaicin which is a major ingredient of red pepper can be expected. However, the further studies including the amount and method of capsaicin administration for preventive effect of oral cancer, should be followed.
9,10-Dimethyl-1,2-benzanthracene* ; Animals ; Capsaicin* ; Capsicum ; Carcinogenesis ; Carcinoma in Situ ; Chemoprevention ; Cricetinae* ; Diet ; Epithelium ; Leukoplakia ; Mesocricetus ; Mouth Neoplasms ; Paint ; Papilloma ; Skin Neoplasms ; Spices ; Stomach ; Wind

Two major salivary glands, submandibular duct, lingual nerve, and vessels are situated beneath the mouth floor. Among these, passing through the pterygomandibular space, lingual nerve is innervated to the lingual gingiva and the mucosa of mouth floor, and is responsible for the general sensation of the anterior two thirds of the tongue. So, the injury of the lingual nerve during an anesthesia or surgery in the retromolar area may cause complications such as a numbness, a loss of taste of the tongue and the other dysfunctions. Therefore, to find out the morphology and the course of lingual nerve and to clarify the topographical relationships of lingual nerve at the infratemporal fossa and paralingual space area, 32 Korean hemi-sectioned heads were dissected macroscopically and microscopically with a viewpoint of clinical aspect in this study. This study demonstrated various anatomical characteristics with relation to the course and topography of the lingual nerve in Koreans. And clinical significances based on the anatomical variations through the topography of the courses and communications between the mandibular nerve branches were described in details.
Anesthesia ; Chorda Tympani Nerve ; Gingiva ; Head ; Hypesthesia ; Lingual Nerve* ; Mandibular Nerve ; Mouth Floor ; Mucous Membrane ; Salivary Glands ; Sensation ; Tongue

A material of 48 patients with 60 avulsed and replanted permanent teeth were followed retrospectively in the period of 1996. 1 to 1998. 12 (mean observation period=1year 7months). The age of the patients at the time of replantation ranged from 9 to 63 years (mean=24 years). Clinical records of patients were reviewed to obtain valid data concerning the extent of injury and treatment provided. Pulpal and periodontal healing states were examined with periapical x-rays and clinical examination procedures (i.e. percussion test and mobility test) at their recall visit. Root ankylosis was found in fifty-two teeth (87%) and root resorption in twenty-four (40%). Only two of the replanted teeth (3%) showed partial regeneration of the periodontal ligament. Six teeth (10%) resulted in tooth loss, but the remaining fifty-four were clinically well functioning. Most of teeth have mild marginal bone loss accompanied by gingival retraction without pathological periodontal pockets. The incidence of root resorption was much higher in younger age group. However, it was not affected by the interval between avulsion and replantation, the condition of supporting tissues, the degree of root formation and the type of splinting, indicating that multiple factors involved in determining the prognosis of replanted teeth. Based on these findings, avulsed teeth in unfavorable conditions (i.e. long extra-alveolar periods, etc.) should be preserved if possible.
Ankylosis ; Humans ; Incidence ; Percussion ; Periodontal Ligament ; Periodontal Pocket ; Prognosis ; Regeneration ; Replantation* ; Retrospective Studies ; Root Resorption ; Splints ; Tooth Loss ; Tooth Replantation ; Tooth*

Orthognathic surgery of the mandibular prognathism and the retrognathism is tend to be performed on the mandibular ramus to prevent inferor alveolar nerve injuries. The purpose of this study is to find a safe and accurate reference point on mandibular ramus for orthognathic surgery by comparative anatomical study of dentofacial deformity patients. We use 38 Korean Cadavers with normal occlusion(Group 1), 3-dimensional simulation of computerized tomogram of 23 patients with retrognathism (Group 2), 27 patients with mandibular prognathism (Group 3). Following results are obtained : 1. The maximum thickness of the mandibular ramus is 8.78+/-1.15mm for Group 2, 7.61+/-1.26mm for Group 1, 6.95+/-0.82mm for Group3 respectively (P=0001). The minimum thickness is 5.51+/-1.08mm for Group 1 , 5.06+/-0.40mm for Group 2, 4.56+/-0.78mm for Group3, respectively (p=0.0001). But, the thickness at the level of 5mm above the lingular is 0.78+/-0.65mm for Group 2, 5.63 +/-1.28mm for Group 1, 5.32+/-0.91mm for Group 3, respectively. There is no significant difference between these groups(P=0.0510). 2. The horizontal location from the midwaist point to lingular is 0.18+/-1.57mm for Group 1, 0.69+/-1.33mm for Group 2, 0.66+/-1.66mm for Group 3, and there is no significant difference between these groups(p=0.0835). But the vertical location from the midwaist point to lingular is 1.45+/-2.64mm for Group 1, 0.63+/-1.44mm for Group 2, 0.34+/-1.81mm for Group 3, and there is significant difference between these groups(p=0.0030). 3. The horizontal location from the midwaist point to mandibular foramen is 0.29+/-1.75mm for Group 1, 0.63+/-1.44mm for Group 2, 0.34+/-1.81mm for Group 3, and there is no significant difference between these groups(p=0.5403). But the vertical location from the midwaist point to mandibular foramen is -3.33+/-4.43mm for Group1, -4.79+/-2.26mm for Group 2, -6.06+/-2.99mm for Group 3, and there is significant difference between these groups(P=0.0001). 4. The horizontal length from the disto-buccal cusp tip of mandibular second molar to lingula is 30.97+/-4.17mm for Group 3, 28.29+/-2.65mm for Group 1, 25.48+/-0.77mm for Group 2 (p=0.0000), and also vertical length is 7.72+/-3.22mm for Group 3, 6.38+/-1.83mm for Group 1, 5.89+/-2.30mm for Group 2 (P=0.0014). 5. The location of lingular is 0.50 from anterior border of mandibular ramus in all groups, if it assumed the length from anterior border to posterior border is 1. And it is almost 0.33 from the sigmoid notch, if it assumed the length from sigmoid notch to antegonial notch is 1. 6. In Group 1, Antilingular prominence is located on (1.12+/-1.43mm, 4.01+/-2.36mm) from the midwaist point, and there is no correlation between antilingular prominence and lingular, mandibular foramen.
Cadaver ; Colon, Sigmoid ; Dentofacial Deformities* ; Humans ; Molar ; Orthognathic Surgery ; Prognathism ; Retrognathia