Among the complications associated with tissue expansion, bony depression under the expander is frequently observed clinically, especially under the tough skin like scalp. To investigate the bony change during the expansion and its reversability, we divided 21 young rabbits into 7 groups. After the insertion of tissue expander on the frontal bone, each groups are sacrificed at 1,2,3 weeks after tissue expansion, 1,2,3 months after removal of tissue expander, and for control, 4 weeks after insertion of expander without expansion. Bony changes are evaluated by gross findings, radiographic findings, and histologic findings. Progressive tissue expansion induces significant gross bony changes in skull of young rabbit. This bony changes consist of erosion underlying tissue expander, with bony ridging and bone deposition at the periphery of the expander. These gross findings correlates with the histomorphologic findings; osteoclastic bone resorption under the expanders with periosteal reation at the periphery of the expanders. The bony changes is not simply a pressure deformation, but also is a remodeling effect. Increased bone resorption and inhibition of bone formation occur until the pressure is removed. After removal of the expanders, reparative bone remodeling begins and nearly complete healing of the cranial defects occurs. On the basis of this study, we conclude that tissue expansion causes significant but reversible effects on cranial bone of young rabbit.
Bone Remodeling ; Bone Resorption ; Depression ; Frontal Bone* ; Osteoclasts ; Osteogenesis ; Rabbits ; Scalp ; Skin ; Skull ; Tissue Expansion Devices ; Tissue Expansion*

Fifty-six patients with tinea versicolor were studied clinically and therapeutically, from July 1984 to August 1985, at the Department of Dermatology, Hanyang University. L atients were treated with 20g sodium thiosulfate solution, 1g isoconazole nitrate cream, lg bifonazole cream and. oral ketoconazole. The result obtained were as follows: 1. The average age of all patients at visit was RO. 1 years, the oldest patient was 72 year-old and the youngest patient was 13 year-old. The male to female ratio was 3. 7: 1. 2. Distribution of lesions were anterior chest(26.8%), back(23.9%), abdomen (19%), axilla (17%), neck(6. 3%), pubic area(4. 2%), upper extremities(1. 4%), hip(0.7%) and lower extremities(0.7%). The incidence of hyperpigmented lesions was 76. 8%, and that of hypopigmented lesions was 23. 2g. 3. Average of treatment duration in each trial group indicated 3. 71-I--0 83 weeks (M+SD) in 20g sodium thiosulfate regimen group, 3. 07+ 0. 73 weeks in 1g isoconazole nitrate, 3.29+1.14 weeks in bifonazole, R. 00+0. 68 weeks in oral ketoconazole. No treatment results show statistically significant differences among the trial groups.
Abdomen ; Adolescent ; Aged ; Axilla ; Dermatology ; Female ; Humans ; Incidence ; Ketoconazole ; Male ; Sodium ; Tinea Versicolor* ; Tinea*

No abstract available.
Osteoma, Osteoid* ; Tetracycline*

OBJECTIVE: To analyze the relationship between the degree of expression of E-cadherin and presence of high risk prognostic factors (lymph node metastasis or parametrium involvement), clinical stages and pathologic types in invasive cervical cancer. METHODS: An immunohistochemical technique has been applied to formalin-fixed, paraffin- embedded samples from 20 radical hysterectomy without risk factors and 16 radical hysterectomy with risk factors. The degree of expressions of E-cadherin immunostaining was compared with the International Federation of Gynecology and Obstetrics (FIGO) stage, presence of high risk prognostic factors, and pathologic types. RESULTS: The difference of the degree of expression of E-cadherin was not statistically significant between high-risk group (lymph node metastasis or parametrium invasion) and non-risk group. The difference of the degree of expression of E-cadherin was not statistically significant according to clinical stages and variable pathologic types either. CONCLUSIONS: These results suggest that the degree of the expression of E-cadherin has no relationship with known high risk prognostic factors, clinical stages and pathologic types in invasive cervical cancer.
Cadherins* ; Gynecology ; Humans ; Hysterectomy* ; Neoplasm Metastasis ; Obstetrics ; Risk Factors ; Uterine Cervical Neoplasms*

No abstract available.

Trichomoniasis, a common and sometimes distressing condition in women, is caused by infection of the genitourinary tract by the pathogenic protozoan Trichomonris aginalis(T. vaginalis). Men may also be infected, although frequently without any symptoms, and most cases of trichomoniasis are sexually transmitted. The best evidence for an etiologic role for T. vaginalis is in nongonococcal urethritis(NGU). In epidemiologic studies, T,ginalis has been isolated from 1 to 68 percent in men with NGU. The nurnber of NGU is increasing rapidly than gonorrhea in deeloped nations, and in some developing countries, especially in Korea, In view of the difficulties in findng trichomonads by direct microsco by in men, urine culture and serodiagnosis plays an important role in the diagnostic work. Urine culture, indirect fluorescent antibody test(IFAT) and enzyme-linked immunosorbent assay (ELISA) were used to elecect T.vaginalis in 221 patients with male NGU. These patients visited the VD Clinic of ChoongKu Public Health Center in Seoul from May to August, 1989 and from March, 1990 to December, 1991. The results obtained were as follows.: 1. T. vaginalis was grown from only one of the 221 samples on TPS-1 meida. 2. In 208 NGU patients, there were 10(4.8%) positive reactions on IgG antibody in IFAT. 3. In 208 NGU patient, there were 14(6.7%) positive reactions to IgG antibody in ELISA. 4. No statistical significant correlation was found between then sults of IFAT and ELISA in individual patients. In conclusion, 1. Male trichomoniasis in patients with NGU was detected at a, significantly low rate. Due to the small number of patients in the test, further epidemiologic stidies of trichomoniasis in male NGU patient are necessary. 2. Serologic studies (IFAT and ELISA) have detected sorre trichomoniasis in male patients with NGU. These tests seem to be helpful in the diagnosis of male t-ichomoniasis.
Developing Countries ; Diagnosis* ; Enzyme-Linked Immunosorbent Assay ; Epidemiologic Studies ; Female ; Gonorrhea ; Humans ; Immunoglobulin G ; Korea ; Male* ; Public Health ; Seoul ; Serologic Tests* ; Urethritis*

BACKGROUND: An Epidemiological study was undertaken to evaluate the prevalence of E. vermicularis infestation among children in kindergartens. METHODS: A total of 247 cellotape anal swab specimens from kindergarten children in Inchon were examined for E. vermicularis eggs. Each specimen was collected in the morning. RESULTS: Out of 247 specimens from two kindergartens in Inchon, E. vermicularis eggs were detected in 168 specimens, the egg detection rate being 68.0%. The egg detection rates in boys and girls were 63.9% out of 133 children and 72.8% out of 114 children, respectively. The egg detection rate in girls was higher than that of boys. The egg detection rates by age group was 65.5%(age 3), S7.4%(age 4), 72.0%(age 5) and 75.4%(age 6), respectively. CONCLUSIONS: Enterobiasis is a cosmopolitan infection. Surveys for children of kindergartens indicate that E.vermicularis is probably the most widely distributed human helminth, its incidence varing from 59.2% to 73.8% in groups studied since pinworm infection is frequently a familial problem that infestation of the household frequently results in reinfection. Careful washing of hands and cleansing of fingernails before meals and after use of the toilet are the most practical measures, all member of family should be treated simultaneously when practicable.
Child* ; Eggs ; Enterobiasis ; Enterobius* ; Epidemiologic Studies ; Family Characteristics ; Female ; Hand ; Helminths ; Humans ; Incheon ; Incidence ; Meals ; Nails ; Ovum ; Prevalence

We experienced a case of erosive adenomatosis of the nipple (EAN) in a 20-year-old lady. She have had an eczematous, erosive and crusted nipple, on the right si.de, with a serosanguineous discharge for the past two years. The biopsy specimen of eczematous lesion on the affected nipple showed focal erosion and acanthosis in the epidermis. Florid intraductal epithelial proliferation and solid nests were scattered in the nipple stroma without showing any cellular pleomorphism. The lining epithelium maintained two layers of cells the inner colurnnar cells and the outer cuboidal cells. Chronic inflammatory infiltrates of relatively dense lymphohisiocytes were found in the surrounding stromal tissue, Paget cells or underlying malignancy were not seen, and a group of tumor netst was confined to the upper part of the subareolar tissue.
Biopsy ; Epidermis ; Epithelium ; Humans ; Nipples* ; Young Adult

BACKGROUND: Histological differentiation between malignant melanoria and benign melanocytic skin lesions is at times, a difficult task for the dermatopathologist. The AgNOR staining has been regarded as a useful tool in differentiating malignant melanoma from benign rael;inocytic nevi. OBJECTIVE: We have carried out the AgNOR staining in a range of nelanocytic lesion and try to assess the value of AgNOR stairting in the identification of malignancy in melanocytic lesions. METHOD: Fifty seven melainocytic skin specimens were studied. These comprised 11 acquired melanocytic nevi, 11 congenital melanocytic nevi, 31 malignant melano nas and 4 atypical melanocytic hyperplasias. RESULT: The majority of benign nevus cells posessed one or two unifrm AgNORs, whereas marked AgNOR pleomorphism was found in some rnelanoma cells. The number of AgNORs per nucleus. averaged 1.24+0.12 in the 18 specimens of benign nevi and 2.10+0.6 in the 25 specimens of malignant melanoma. In the cases of atypical melanocytic hyperplasia it was not possible to count on an adequate number of cells to give a meaningful result because of melanin pigment. CONCLUSION: Although this study demonstrated a separation of average AgNOR counts between begnign melanocytic nevi and maligmant melanomas, there was an ovei lap in counts among individual lesions. For clinical use, there should be a standard method by which AgNORs are counted in AgNOR staining. Melanin pigment masiking the AgNORs can also be a problem.
Hyperplasia ; Melanins ; Melanoma ; Nevus ; Nevus, Pigmented ; Skin*

No abstract available.
Glycerol* ; Hearing*