1.The influence of estazolam on human neurobehavioral function.
Journal of Forensic Medicine 2010;26(1):30-32
OBJECTIVE:
To study the relation between human blood estazolam concentration and neurobehavioral function.
METHODS:
The neurobehavioral ability of 10 volunteers were measured with computer-administered neurobehavioral evaluation system-chinese3 (NES-C3) and SMART EquiTest system.
RESULTS:
The neurobehavioral ability and balance function declined 1 h later after dosing estazolam. The neurobehavioral ability index and balance function declined to the lowest level 3 h later after dosing estazolam. The neurobehavioral ability recovered partly 6 h later after dosing estazolam, and neurobehavioral ability recovered completely 10 h later.
CONCLUSION
Driving ability was impaired when estazolam concentration in blood is 20 ng/mL, and the neurobehavioral ability declined when estazolam concentration is 40 ng/mL in blood. The influence to human in absorption process is greater than the metabolic process with the same estazolam concentration.
Accidents, Traffic/prevention & control*
;
Administration, Oral
;
Adult
;
Anticonvulsants/pharmacokinetics*
;
Attention/drug effects*
;
Behavior/drug effects*
;
Estazolam/pharmacokinetics*
;
Female
;
Humans
;
Male
;
Neuropsychological Tests
;
Psychomotor Performance/drug effects*
;
Reaction Time