1.Anticoagulation in the treatment of portovenous emboli after cyanoacrylate injection for a bleeding gastric varix.
Charlene Xian Wen KWA ; Veronique Kiak Mien TAN ; Hock Soo ONG
Singapore medical journal 2015;56(1):e14-6
We herein report the use of endoscopic n-butyl-2-cyanoacrylate injections to obliterate a gastric varix, which led to cyanoacrylate embolisation in the splenic and portal veins in a single patient. Cyanoacrylate embolisation is a known but uncommonly reported complication of endoscopic sclerotherapy. This case report illustrates the successful management of this complication (i.e. cyanoacrylate embolisation in the splenic and portal veins) with anticoagulation and analyses the presentation and management of other cases of cyanoacrylate embolisation reported in the literature.
Aged
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Anticoagulants
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chemistry
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therapeutic use
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Blood Pressure
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Cyanoacrylates
;
chemistry
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Embolism
;
chemically induced
;
diagnostic imaging
;
therapy
;
Esophageal and Gastric Varices
;
drug therapy
;
Humans
;
Injections
;
Male
;
Portal Vein
;
pathology
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Sclerotherapy
;
Splenic Vein
;
pathology
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Tomography, X-Ray Computed
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Ultrasonography, Doppler
2.A Case of Portal Hypertension after the Treatment of Oxaliplatin Based Adjuvant-Chemotherapy for Rectal Cancer.
Jun HEO ; Keun Young SHIN ; Yong Hwan KWON ; Soo Young PARK ; Min Kyu JUNG ; Chang Min CHO ; Won Young TAK ; Young Oh KWEON
The Korean Journal of Gastroenterology 2011;57(4):253-257
We report herein a case of 35-years-old woman in whom portal hypertension (esophageal varix and splenomegaly) developed after 12 cycles of oxaliplatin based adjuvant chemotherapy for rectal cancer. She was transferred for the evaluation of etiology of new-onset portal hypertension. The esophageal varix and splenomegaly were absent before the oxaliplatin based adjuvant chemotherapy. Thorough history taking and serological exam revealed no evidence of chronic liver disease. Liver biopsy was done and there was no cirrhotic nodule formation. Instead, perivenular fibrosis was noted. Considering new development of esophageal varices and splenomegaly after 12 cycles of oxaliplatin-based adjuvant chemotherapy, we could conclude that portal hypertension in this patient were due to sinusoidal injury by oxaliplatin. Finally, we recommend regular follow-up with endoscopy and radiologic examination for checking the development of varices and for screening of varices and splenomegaly in patients with colo-rectal cancer who receive oxaliplatin-based chemotherapy.
Adult
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Antineoplastic Agents/*adverse effects/therapeutic use
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Chemotherapy, Adjuvant
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Esophageal and Gastric Varices/chemically induced
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Female
;
Fibrosis
;
Humans
;
Hypertension, Portal/chemically induced/*diagnosis
;
Liver/pathology
;
Organoplatinum Compounds/*adverse effects/therapeutic use
;
Positron-Emission Tomography
;
Rectal Neoplasms/*drug therapy/surgery
;
Splenomegaly/chemically induced
;
Tomography, X-Ray Computed
3.A Case of Portal Hypertension after the Treatment of Oxaliplatin Based Adjuvant-Chemotherapy for Rectal Cancer.
Jun HEO ; Keun Young SHIN ; Yong Hwan KWON ; Soo Young PARK ; Min Kyu JUNG ; Chang Min CHO ; Won Young TAK ; Young Oh KWEON
The Korean Journal of Gastroenterology 2011;57(4):253-257
We report herein a case of 35-years-old woman in whom portal hypertension (esophageal varix and splenomegaly) developed after 12 cycles of oxaliplatin based adjuvant chemotherapy for rectal cancer. She was transferred for the evaluation of etiology of new-onset portal hypertension. The esophageal varix and splenomegaly were absent before the oxaliplatin based adjuvant chemotherapy. Thorough history taking and serological exam revealed no evidence of chronic liver disease. Liver biopsy was done and there was no cirrhotic nodule formation. Instead, perivenular fibrosis was noted. Considering new development of esophageal varices and splenomegaly after 12 cycles of oxaliplatin-based adjuvant chemotherapy, we could conclude that portal hypertension in this patient were due to sinusoidal injury by oxaliplatin. Finally, we recommend regular follow-up with endoscopy and radiologic examination for checking the development of varices and for screening of varices and splenomegaly in patients with colo-rectal cancer who receive oxaliplatin-based chemotherapy.
Adult
;
Antineoplastic Agents/*adverse effects/therapeutic use
;
Chemotherapy, Adjuvant
;
Esophageal and Gastric Varices/chemically induced
;
Female
;
Fibrosis
;
Humans
;
Hypertension, Portal/chemically induced/*diagnosis
;
Liver/pathology
;
Organoplatinum Compounds/*adverse effects/therapeutic use
;
Positron-Emission Tomography
;
Rectal Neoplasms/*drug therapy/surgery
;
Splenomegaly/chemically induced
;
Tomography, X-Ray Computed