Erythroplasia of Queyrat is an uncommon form of carcinoma in situ involving the glans penis and adjacent mucosal structures. Treatment modalities of Erythroplasia of Queyrat vary widely and topical 5-fluorouracil treatment is very effective and regarded as the choice of t eatment. This article reports a case of erythroplasia of Queyrat involving the perimeatal region of the glans penis and identifies the difficulty of effectively treating erythroplasia of Queyrat which is adjaer to the urethral meatus with 5-fluorouracil and usefulness of electron beam irradiation therapy.
Carcinoma in Situ ; Erythroplasia* ; Fluorouracil ; Male ; Penis*

We herein reported a typical case of erythroplasia of Queyrat in a 35-year-old male patient who had a 6 month-duration of a erythroplastic lesion on the glans penis and coronal sulcus. He was treated 5% 5-fluorouracil cream under occlusion twice a day for 10 days. Three months after treatment, no erythroplastic lesion was found and rebiopsy showed marked improvement histopathologically.
Adult ; Erythroplasia* ; Fluorouracil* ; Humans ; Male ; Penis

Imiquimod is a new immunomodulating agent with antitumor and antiviral properties that has been shown to be clinically effective in various kinds of skin diseases, including precancerous dermatoses. Erythroplasia of Queyrat is a carcinoma in situ that mainly occurs on the glans penis. There are several non-invasive treatment options for erythroplasia of Queyrat such as photodynamic therapy, cryosurgery and applying various kinds of topical agents. We now report a case of typical erythroplasia of Queyrat on glans penis associated with human papillomavirus type 16 infection that was treated by imiquimod 5% cream and the subsequent excision of an imiquimod-resistant penile lesion.
Aminoquinolines ; Carcinoma in Situ ; Cryosurgery ; Erythroplasia ; Humans ; Male ; Penis ; Photochemotherapy ; Skin Diseases

BACKGROUND: The incidence of cutaneous squamous cell carcinoma(SCC) has been increasing, but no analysis of the causative diseases of cutaneous SCC has been performed. OBJECTIVE: The purpose of this study was to investigate the causative disease of SCC. METHODS: Eighty-seven patients with cutaneous SCC were retrospectively studied. RESULTS: The possible causative diseases of cutaneous SCC were actinic keratosis(18 csaes), Bowen's disease(17 cases), actinic cheilitis(8 cases), burn scar(4 cases), arsenical keratosis(3 cases), xeroderma pigmentosum(3 cases), chronic discoid lupus erythematosus(2 cases), epidermodysplasia verruciformis(2 cases), leukoplakia(1 case), chronic radiodermatitis(1 cases), erythroplasia of Queyrat (1 case), osteomyelitis sinus(1 case), lichen planus(1 case), porokeratosis of Mibelli(1 case), and the other 21 cases were of unknown origin. CONCLUSION: The causative diseases of cutaneous SCC were related to sun-exposure, and chronic dermatoses.
Actins ; Burns ; Carcinoma, Squamous Cell* ; Erythroplasia ; Humans ; Ichthyosis ; Incidence ; Lichens ; Osteomyelitis ; Porokeratosis ; Retrospective Studies ; Skin Diseases

BACKGROUND: The incidence of cutaneous squamous cell carcinoma(SCC) has been increasing, but no analysis of the causative diseases of cutaneous SCC has been performed. OBJECTIVE: The purpose of this study was to investigate the causative disease of SCC. METHODS: Eighty-seven patients with cutaneous SCC were retrospectively studied. RESULTS: The possible causative diseases of cutaneous SCC were actinic keratosis(18 csaes), Bowen's disease(17 cases), actinic cheilitis(8 cases), burn scar(4 cases), arsenical keratosis(3 cases), xeroderma pigmentosum(3 cases), chronic discoid lupus erythematosus(2 cases), epidermodysplasia verruciformis(2 cases), leukoplakia(1 case), chronic radiodermatitis(1 cases), erythroplasia of Queyrat (1 case), osteomyelitis sinus(1 case), lichen planus(1 case), porokeratosis of Mibelli(1 case), and the other 21 cases were of unknown origin. CONCLUSION: The causative diseases of cutaneous SCC were related to sun-exposure, and chronic dermatoses.
Actins ; Burns ; Carcinoma, Squamous Cell* ; Erythroplasia ; Humans ; Ichthyosis ; Incidence ; Lichens ; Osteomyelitis ; Porokeratosis ; Retrospective Studies ; Skin Diseases

A 47-year-old woman presented with a large, gray, verrucous plaque rapidly growing on the vulva for 8 months. Histopathologically, the lesion showed a marked hyperkeratosis, acanthosis, papillomatosis, and dysregulated epidermal hyperplasia with atypical hyperchromatic cells. The basement membrane zone remained intact. Human papilloma virus type 16 and 18 was detected in the lesional area by in situ hybridization. Based on these findings, the lesion was identified as vulvar intraepithelial neoplasia (VIN). Although vulvar lesions are examined by both dermatologists and gynecologists, their diagnostic jargon of the verrucous, hyperplastic plaque that shows intraepithelial neoplasia, is not always concordant. We believe that VIN could be a better substitute for large bowenoid papulosis, Bowen's disease or vulvar erythroplasia of Queyrat.
Basement Membrane ; Bowen's Disease ; Erythroplasia ; Female ; Humans ; Hyperplasia ; In Situ Hybridization ; Middle Aged ; Papilloma ; Vulva

Erythroplasia of Queyrat is an uncommon intraepithelial carcinoma in situ affecting the mucosal surface of the penis with a significant risk of invasion. Treatment is often difficult and is associated with significant recurrence rates. Topical 5-fluorouracil treatment is very effective and regarded as the treatment of choice for histologically confirmed erythroplasia of Queyrat because of its superior results compared with those of surgery or radiation therapy. We report a typical case of erythroplasia of Queyrat involving the mucosa of the glans penis in a 64-year-old male patient who was treated by topical 5% 5-Fluorouracil cream and has achieved a long-term complete response and no recurrence after 12months.
Carcinoma in Situ ; Erythroplasia* ; Fluorouracil* ; Humans ; Male ; Middle Aged ; Mucous Membrane ; Penis ; Recurrence

Erythroplasia ; diagnosis ; epidemiology ; therapy ; Humans ; Leukoplakia, Oral ; diagnosis ; epidemiology ; therapy ; Mouth Mucosa ; pathology

Erythroplasia of Queyrat is a precancerous lesion, usually located to glans penis or prepuce. It is characterized by a slowly developing, circumscribed, usually velvety and shiny patch. The etiology was unknown, but it is extremely rare in those circumcised in early infancy. It had been suggested that phimosis had some etiologic importance. The typical case of Erythroplasia of Queyrat is presented. A 46 year old man had 4 months history of dark-brownish pea sized maculopapular rashes on sulcus of glans penis and prepuce associated with mild itching, which was increased in number day by day. He had a phimosis. On examination, there are sharply defined, slightly elevated, pea sized dark-brownish maculopapular rashes over erythematous infiltrated base on sulcus of glans penis and prepuce, which have moist and velvety appearance. A biopsy was performed from sulcus of glans penis. Histopathologically, there was acanthosis, with in epidermis many cells are vacuolated and showed individual cell keratiinization. Epithelial cell showed marked atypia, variation in nuclear size and there was intercellular, intracellular edema. The lesion was treaterd with topical application of 5% 5-fluorouracil twice daily 2 weeks and thereafter for 4 weeks. 2 months after treatment, no erythroplastic lesion was found and 3 months after treatment, rebiopsy was perforrned which showed marked improvement histopathologically.
Biopsy ; Edema ; Epidermis ; Epithelial Cells ; Erythroplasia* ; Exanthema ; Female ; Fluorouracil* ; Humans ; Male ; Middle Aged ; Peas ; Penis ; Phimosis ; Pruritus

BACKGROUND: A variety of infectious, inflammatory, and neoplastic dermatoses can develop on the glans penis, and definitive diagnosis in such cases may be difficult owing to their non-specific symptoms and clinical appearance. Furthermore, data on dermatoses of the glans penis in Korea are limited. OBJECTIVE: In the present study, we aimed to determine the prevalence of dermatoses of the glans penis in Korea and provide clinical data to assist in making an accurate diagnosis. METHODS: We retrospectively reviewed the medical records, clinical photographs, and histologic slides of 65 patients with dermatoses of the glans penis that visited the Pusan National University Hospital between January 2004 and August 2013. RESULTS: Twenty-six types of dermatoses were identified: inflammatory dermatosis was the most common (38/65, 58.5%), followed by infectious (13/65, 20.0%), neoplastic (10/65, 15.4%), and other dermatoses (4/65, 6.2%). The most common dermatosis of the glans penis was seborrheic dermatitis, followed by lichen planus, herpes progenitalis, condyloma accuminatum, erythroplasia of Queyrat, Zoon's balanitis, and psoriasis. In the topographic analysis, the most common type of dermatosis was dermatoses that localized to the glans penis (39/65, 60.0%), followed by dermatoses involving the extra-genitalia and glans penis (22/65, 33.9%), and the genitalia (glans penis plus other genital areas) (4/65, 6.2%). CONCLUSION: This study shows the usefulness of a topographic approach in the diagnosis of dermatoses of the glans penis in Korea. The findings could be used as baseline data for establishing an accurate diagnosis in Koreans.
Balanitis ; Busan ; Dermatitis, Seborrheic ; Diagnosis ; Erythroplasia ; Genitalia ; Humans ; Korea* ; Lichen Planus ; Male ; Medical Records ; Penis* ; Prevalence ; Psoriasis ; Retrospective Studies ; Skin Diseases*