Hemolytic disease of the newborn (HDN) caused by anti-M is rare and clinical manifestations are variable ranging from mild anemia and hyperbilirubinemia to hydrops fetalis and intrauterine fetal death. There were few reports of HDN caused by anti-M in Korea but no case in siblings. We experienced a case of 2 male siblings, both of whom had anti-M induced HDN and prolonged anemia persisted for over a month. We report this case with a brief review of literature. This report documents the first case of HDN caused by anti-M in siblings in Korea.
Anemia ; Erythroblastosis, Fetal ; Fetal Death ; Humans ; Hydrops Fetalis ; Hyperbilirubinemia ; Infant, Newborn* ; Jaundice ; Korea ; Male* ; Siblings*

Fetal erythroblastosis caused by maternal Rhesus alloimmunization brings a significant clinical problem, eventually leading to fetal hydrops and intrauterine fetal death. Repeated blood transfusions into the umbilical vein are the treatment of choice for fetal erythroblastosis with severe hydrops. The purpose of this report is to introduce our experience with a case of fetal erythroblastosis, recovered after intraumbilical venous transfusions. The fetus has been received the intraumbilical venous transfusions for four times from 29 weeks of gestation. Fetal hydrops and cardiomegaly, as well as polyhydramnios were improved markedly after transfusions. A healthy baby was delivered at 34 weeks of gestation. Intraumbilical venous transfusion may be a safe and effective treatment on the case with severe aggressive anemic and hydropic isoimmune fetus.
Blood Transfusion ; Cardiomegaly ; Edema ; Erythroblastosis, Fetal* ; Fetal Death ; Fetal Therapies ; Fetus ; Hydrops Fetalis ; Infant, Newborn ; Polyhydramnios ; Pregnancy ; Umbilical Veins

Fetal pericardial effusion appears as a common type of fetal hydrops, but rarely isolated. The causes are heart failure by cardiac anomaly and arrhythmia (most common), kidney anomaly, erythroblastosis fetalis, non-immune fetal hydrops, intrauterine growth retardation, chromosomal anomaly and transient etc. If chromosomal anomalies such as 21 trisomy, 18 trisomy or 13 trisomy exists, isolated pericardial effusion may exist without cardiac anomaly or arrhythmia. Otherwise, the chromosomal anomaly must be suspected when isolated pericardial effusion is observed on fetal echocardiography. We experienced a case of large amount of isolated pericardial effusion antenatally detected by fetal echocardiography at 32weeks of gestational age in a neonate who needed pericardiocentesis and confirmed trisomy 21. We report a case of isolated pericardial effusion with brief review of related literature.
Arrhythmias, Cardiac ; Down Syndrome* ; Echocardiography ; Erythroblastosis, Fetal ; Fetal Growth Retardation ; Gestational Age ; Heart Failure ; Humans ; Hydrops Fetalis ; Infant, Newborn* ; Kidney ; Pericardial Effusion* ; Pericardiocentesis ; Trisomy*

Fetal pericardial effusion appears as a common type of fetal hydrops, but rarely isolated. The causes are heart failure by cardiac anomaly and arrhythmia (most common), kidney anomaly, erythroblastosis fetalis, non-immune fetal hydrops, intrauterine growth retardation, chromosomal anomaly and transient etc. If chromosomal anomalies such as 21 trisomy, 18 trisomy or 13 trisomy exists, isolated pericardial effusion may exist without cardiac anomaly or arrhythmia. Otherwise, the chromosomal anomaly must be suspected when isolated pericardial effusion is observed on fetal echocardiography. We experienced a case of large amount of isolated pericardial effusion antenatally detected by fetal echocardiography at 32weeks of gestational age in a neonate who needed pericardiocentesis and confirmed trisomy 21. We report a case of isolated pericardial effusion with brief review of related literature.
Arrhythmias, Cardiac ; Down Syndrome* ; Echocardiography ; Erythroblastosis, Fetal ; Fetal Growth Retardation ; Gestational Age ; Heart Failure ; Humans ; Hydrops Fetalis ; Infant, Newborn* ; Kidney ; Pericardial Effusion* ; Pericardiocentesis ; Trisomy*

No abstract available.
Erythroblastosis, Fetal* ; Infant, Newborn

No abstract available.
Erythroblastosis, Fetal* ; Infant, Newborn

No abstract available.
Erythroblastosis, Fetal* ; Infant, Newborn

No abstract available.
Erythroblastosis, Fetal* ; Gene Frequency* ; Infant, Newborn

No abstract available.
Erythroblastosis, Fetal* ; Humans ; Infant, Newborn ; Siblings*

ABO Blood-Group System ; Erythroblastosis, Fetal ; epidemiology ; Humans ; Infant, Newborn