Sixty-six cases of erythena nodosum(EN) and erythema induraturn(EI) were examined pathologically and clinically. Pathologically 23 cases were erythema nodosum, 43 cases were erytherna induratum. Pathological diagnosis made without any prior knowledge of the clinical and laboratory data. Clinical manifestations were reviewed on basis of pathological diagnosis. The results are as follows; l. EN and EI mainly occurred in female, age of twenties and during spring season. There was no difference in sex, age and seasonal incidence between EN and EI. 2. Both EN and EI affected chiefly the shins. EI was more common than EN in cases of calf involvement. 3. Tenderness and systemic symptoms developed more often in EN, while ulcers occurred only in EI. 4 EI had relatively long duration. There was no difference in the recurrence rate between EN and EI. 5. Pulmonary tuberculosis was found only in El on chest X-rays. 6. Clinical and pathological diagnosis was identical in almost cases of EN but those were variable in case of EI.
Diagnosis ; Erythema Induratum* ; Erythema Nodosum* ; Erythema* ; Female ; Humans ; Incidence ; Recurrence ; Seasons ; Thorax ; Tuberculosis, Pulmonary ; Ulcer

BACKGROUND: The histopathological findings of acute cutaneous graft-versus-host reaction are similar to that of erythema multiforme. OBJECTIVE: The objective of this study was to compare the histopathological findings of acute cutaneous graft-versus-host reactions with that of erythema multiforme. METHODS: Histopathological setions of 9 patients with grade 2 acute cutaneous graft-versus- host. reactions and of 13 patient,, with erythema multiforme were reviewed. RESULTS: Parakeratosis, the degree of the exocytosis and the endothelial cell swelling were not useful in the differential diagnosis between acute cutaneous graft-versus-host reactions and ery- thema multiforme. Rete ridge effacement and relative hyperkeratosis were characteristic in many cases of acute cutaneous graft-versus-host reactions but absent in erythema multiforme. Spongiosis, vacuolar degeneration of the basal cells, perivascular lymphocytic infiltration and erythrocyte extravasation were usually more prominent in erythema multiforme than in acute cutaneous graft-versus-host reactions. The number of dyskeratotic cells per epidermal linear mm was usually higher in erythema multiforme but not in acute cutaneous graft-versus-host reactions. An eosinophilic infiltrate was observed occasionally in erythema multiforme but not in acute cutaneous graft-versus-host reactions. CONCLUSION: The histopathological findings show the same pattern of interface dermatitis and are different only in degree beween acute cutaneous graft-versus-host reactions and eryt,hema multiforrne. Rete ridge effacement and relative hyperkeratosis speaks for a diagnosis of acute cutaneous graft-versus-host reactions, and an eosinophilic infiltrate for a diagnosis of erythema multiforme.
Dermatitis ; Diagnosis ; Diagnosis, Differential ; Endothelial Cells ; Eosinophils ; Erythema Multiforme* ; Erythema* ; Erythrocytes ; Exocytosis ; Humans ; Parakeratosis ; Transplants*

A clinical and histopsthological study were done on 1,817 biopsied inflammatory skin diseases among 58,386 out-patients in Dermatologic department of Korea University Hospital during the period of 24 years from January, 1962 to December, 1985. The results were summarized as follows : 1. According to pattern analysis(Ackerman AB), 1,605 cases(88.3%) of inflammatory skin diseases were classified into 9 patterns and by author's modified pattern analysis, additional 437 cases could be classified. 2. Of the 1605 cases which were classified by 9 pattern analysis, 1185 cases(78.8%) of inflammatory skin diseases were diagnosed as individual disease entity. The ratio of accordance between the histopathological diagnosis and clinical diagnosis on the biopsied inflammatory skin diseases was 44.5%, 3. The ratio of accordance between the histopathological diagnosis and clinical diagnosis by the patterns were '. Vasculitis(75.5%), Subepidermal vesicular dermatitis (73.3%), Nodular and diffuse dermatitis(68.2%), etc. 4. The diseases showing above the 70% accordance were scleroderma, erythema induratum, vitiligo, arthropod reaction, etc; and the diseases showing under the 30% accnrdance were erythema multiforme, erythema annulare centrifugum, neurodermatitis, etc.
Arthropods ; Biopsy* ; Dermatitis ; Diagnosis ; Erythema ; Erythema Induratum ; Erythema Multiforme ; Humans ; Korea ; Neurodermatitis ; Outpatients ; Skin Diseases* ; Skin* ; Vitiligo

Erythema nodosum is clinical entity defined easily, but because of the variable histopathologic findings showing involvement of the vessels, septa, and fat lobules, the histopathologic features often are not compatible with the clinical diagnosis, We present the results of clinical and histopathologic findings in 26 patients with erythema nodosum observed at the Department of Dermatology, Seoul National University Hospital, fram January 1973 to August 1976. 1. Clinical Findings Erythema nodosum is characterized by painful erythematous nodose lesion occurring symmetrically(92%) on shins(50%) or shins and calves(50%) of women(M: F==4: 22) between sixteen to twenty five years old of age(58%) chiefly. In laboratory study, leukocytosis(1/17) was rare but increased titers of antistreptolysin(64%) and elevation of E.S.R.(88%) were found frequently. 2. Histopathologic Findings Even though hemorrhage(73%), perivascular(100%) and periadnexal(85%) inflammatory cell infiltration were frequently seen in histopathologic changes of erythema nodosum, these changes were nonspecific. Moreover, granulomatous change (38%), thrombophlehitis(35%) and necrosis of fatty tiasue(38%) were observed not infrequently in erythema nodosum. So we concluded that there were no specific histopathologic findings in erythema nodosum which differentiated from the other erythematous nodose diseases on the legs consisted of panniculitis, thrombophlebitis or granulomatous changes.
Dermatology ; Diagnosis ; Erythema Nodosum* ; Erythema* ; Humans ; Leg ; Necrosis ; Panniculitis ; Seoul ; Thrombophlebitis

Autoimmune progesterone dermatitis is a rare disorder involving hypersensitivity to progesterone. It is most frequently characterized by recurrent erythema multiforme, eczematous or urticarial eruptions during the luteal phase of the menstrual cycle. It resolves or partially improves after menstruation. Sensitivity is demonstrated by a challenge test with medroxyprogesterone acetate. The therapeutic goal for autoimmune progesterone dermatitis is the suppression of ovulation. Currently, the first-line choice of therapy is a combination oral contraceptive. Here, we report a case of autoimmune progesterone dermatitis that manifested as cyclic bullous erythema multiforme. A reactive intradermal progesterone test confirmed the diagnosis.
Dermatitis* ; Diagnosis ; Erythema Multiforme* ; Erythema* ; Female ; Hypersensitivity ; Luteal Phase ; Medroxyprogesterone Acetate ; Menstrual Cycle ; Menstruation ; Ovulation ; Progesterone*

Diagnosis, Differential ; Erythema Multiforme ; diagnosis ; Erythema Nodosum ; diagnosis ; Female ; Humans ; Leg Dermatoses ; diagnosis ; Middle Aged ; Mycosis Fungoides ; diagnosis ; Skin Neoplasms ; diagnosis ; Sweet Syndrome ; diagnosis

Gastric cancer resembling subepithelial tumor is rare. It comprises approximately 0.5% of all resected gastric cancer cases. The features of gastric carcinoma resembling subepithelial tumor are erosion, erythema and central umbilication. Because only a small amount of cancerous tissue is present at the mucosal layer, differential diagnosis between subepithelial tumor and gastric cancer resembling subepithelial tumor is difficult. EUS is recommended to identify the origin and echogenicity of the lesion, characteristic features, and accurate size. We report a case of early gastric cancer misdiagnosed as a subepithelial tumor on the basis of standard endoscopy and EUS findings in a 63-year-old woman. The patient received endoscopic resection and additional surgical operation was performed to achieve complete resection.
Adenocarcinoma ; Diagnosis, Differential ; Endoscopy ; Erythema ; Female ; Humans ; Stomach Neoplasms

Gastric cancer resembling subepithelial tumor is rare. It comprises approximately 0.5% of all resected gastric cancer cases. The features of gastric carcinoma resembling subepithelial tumor are erosion, erythema and central umbilication. Because only a small amount of cancerous tissue is present at the mucosal layer, differential diagnosis between subepithelial tumor and gastric cancer resembling subepithelial tumor is difficult. EUS is recommended to identify the origin and echogenicity of the lesion, characteristic features, and accurate size. We report a case of early gastric cancer misdiagnosed as a subepithelial tumor on the basis of standard endoscopy and EUS findings in a 63-year-old woman. The patient received endoscopic resection and additional surgical operation was performed to achieve complete resection.
Adenocarcinoma ; Diagnosis, Differential ; Endoscopy ; Erythema ; Female ; Humans ; Stomach Neoplasms

OBJECTIVE: The typical clinical feature of chronic cutaneous lupus erythematosus (CCLE) is 'discoid erythema'; however, several different clinical variants exist such as hypertrophic LE, LE profundus, chilblain LE, tumid LE and so on. The heterogeneity-spectrum of the lesional morphology of the cutaneous lesions and the predilection sites of the lesions of twenty Korean patients with CCLE were examined and tried to compare to those of CCLE patients of Caucasian origin. METHODS: Clinical examinations of twenty patients with CCLE were carried out by dermatologists to define the morphologic characteristics of cutaneous lesions and the anatomic predilection sites of the lesions. RESULTS: The most common cutaneous lesion-morphology noted in Korean patients with CCLE was classic discoid erythema. Three cases had concurrent cutaneous lesions of other clinical variants of CCLE. The predilection sites of all lesions were the face (cheeks) and head (frontal area). These clinical findings observed among this group of patients are similar to those features seen in people of Caucasian origin. CONCLUSION: The most frequent clinical feature of CCLE was discoid erythema and the predilections sites of the lesions found were the face and the scalp; indicating that the morphological heterogeneity-spectrum of cutaneous lesions and the predilection sites observed in Korean patients of CCLE seem to have no remarkable differences when compared with Caucasian cases with the same diagnoses.
Chilblains ; Diagnosis ; Erythema ; Head ; Humans ; Lupus Erythematosus, Cutaneous* ; Scalp

BACKGROUND: Dermoscopic features may be useful in verifying the clinical diagnosis and increasing the diagnostic accuracy of dermatofibroma. There have been no systematic analyses of the dermoscopic features of dermatofibroma in Koreans or studies regarding the correlation between dermoscopic features and histologic subtypes. OBJECTIVE: To investigate the dermoscopic features of dermatofibroma in Koreans and to explore the relationship between the dermoscopic features and histologic subtypes of dermatofibroma. METHODS: The study included 83 lesions from 61 patients with dermatofibroma. Dermoscopic examination was performed via hand-held polarized dermoscopy at 10x magnification. Images were documented using a digital camera with a 3-fold optical zoom. RESULTS: The main dermoscopic structures were pigment network (63.9%), white scar-like patch (53.0%), and homogeneous area (50.6%). The frequency of homogeneous area (50.6%), scale (50.6%), ring-like structure (36.1%), exophytic papillary structure (7.2%), and telangiectasia (6.0%) was significantly higher, and globule-like structure (20.5%) and erythema (8.4%) was significantly lower in Koreans than in Caucasians (p<0.05). Eleven dermoscopic patterns including a peripheral delicate pigment network and central white scar-like patch (28.9%) and total delicate pigment network (15.7%) were observed and there was no significant difference compared to Caucasians. Seven histologic types were observed; however, the correlation between dermoscopic features and histologic subtypes was not significant. CONCLUSION: The most common pattern of dermatofibroma was pigment network and central white scar-like patch in both Koreans and Caucasians. A correlation between dermoscopic features and histologic subtypes in dermatofibroma was not found. These results may be helpful in clinically diagnosing dermatofibroma, especially in Koreans.
Dermoscopy ; Diagnosis ; Erythema ; Histiocytoma, Benign Fibrous* ; Humans ; Telangiectasis