1.Therapeutic effect analsysis of ultrasound-guided radioactive 125I seed implantation in the treatment of hepatic tumors at dangerous sites
Erpeng QI ; Fangyi LIU ; Shuilian TAN ; Yanyan HU ; Dengfa GAO ; Xiaoling YU
Chinese Journal of Hepatobiliary Surgery 2019;25(3):161-163
Objective To study the local efficacy of ultrasound-guided interstitial implantation of radioactive 125I seeds in the treatment of hepatic tumors at dangerous sites.Methods A retrospective study was conducted on 39 patients who were admitted into the First Medical Center,PLA General Hospital from November 2011 to January 2018.There were 23 males and 16 females.A three-dimensional planning before 125I seed implantation was performed for all these patients using the treatment planning system (TPS).The implantation was performed under ultrasound guidance.Liver CT scan was performed in all the patients after implantation to evaluate the actual distribution of the seeds in the tumors.Follow-up was performed at 2,4,6,9 and 12 months after implantation,respectively,to evaluate using complete response (CR),partial response (PR),steady disease (SD),progressive disease (PD) and local control rates (LCR).Results Implantation was successfully performed in all the 39 patients.CT scan showed that 5 patients (12.8%)required additional implantation.Follow-up imaging after implantation showed local control of the lesions was good.The rates of CR,PR,SD and LCR were 2.6% (1/39),28.2% (11/39),66.7% (26/39) and 97.4% (38/39),respectively.One patient (2.6%,1/39) showed local progressive disease.The LCR reached 97.4% (38/39) at 12 months of follow-up.Conclusion Ultrasound-guided radioactive 125I seed implantation was efficacious in the treatment of hepatic tumors at dangerous sites.
2. Effect of erythropoietin on the expression of aquaporin 2-3 after the release of unilateral ureter obstruction in young rats
Jinjin FENG ; Shaohua YAN ; Xi GUO ; Yan CHEN ; Yibo WEN ; Yunlong LI ; Yulin HE ; Xiangfei HE ; Yuan MA ; Erpeng LIU ; Pan SONG ; Dong XING ; Qi LI ; Jianguo WEN
Chinese Journal of Applied Clinical Pediatrics 2019;34(21):1653-1657
Objective:
To investigate the effect of erythropoietin (EPO) on the expression of aquaporin 2-3 after the release of unilateral ureter obstruction in young rats.
Methods:
Twenty-four SD rats were randomly divided into 3 groups(CUUO-R group, CUUO-R+ EPO group and sham group, with 8 rats in each group). The CUUO-R model was built through unilateral ureteral ligation, after 48 h the obstruction was released.EPO was given to the CUUO-R+ EPO group at the time point of removing obstruction, and then repeated every other day for 1 week, and the same volume of saline was simultaneously given to the CUUO-R rats.The rats in sham group experienced the laparotomy and free dissection of left ureter but not ligation.The kidneys were harvested 7 d after the release of CUUO.The methods of Western blot and immunohistochemistry were used to examine the effects of erythropoietin on the expression of AQP2 and AQP3.
Results:
The osmotic pressure of CUUO-R+ EPO group was higher than those of CUUO-R group, but lower than that of sham group(