Objective To evaluate the preventive effect of BCG-PSN on respiratory infection of patients with chronic obstructive pulmonary disease.Methods 48 cases with COPD were randomly divided into two groups:the BCG-PSN group and the control group.The BCG-PSN group received BCG-PSN,0 5mg,im,twice a week for 18 times injection in addition to the routine therapy,and the control group only received routine therapy.Both groups were followed up every two weeks for six months.The serum IgA,IgG,IgM levels were determined before and 4,24 weeks after the treatment.Results Cases of infection and their lasting days,infective rate in the BCG-PSN group were significantly lower than that of the control group(P

Objective To observe the clinical efficacy ofTiaozhong YifeiPrescription combined with Western therapy for treatment of cough variant asthma (CVA) remission. Methods Totally 90 patients with CVA remission were randomly divided into TCM group, Western therapy group and TCM and Western therapy group, 30 cases in each group. TCM group was givenTiaozhong YifeiPrescription, 1 dose per day, morning and evening; Western therapy group was given salmeterol xinafoate and fluticasone propionate powder for inhalation, each 1 suction, 2 times a day, inhalation; a mixture ofTiaozhong YifeiPrescription and xinafoate and fluticasone propionate powder for inhalation was given to TCM and Western therapy group, the same as above, continuous treatment for 12 weeks. TCM syndrome score, EOS, IgE, pulmonary function and safety index were observed in the three groups before and after treatment. The recurrence rate and the number of colds after three-month treatment were observed.Results TCM syndrome scores in the three groups decreased after treatment (P<0.05). There was statistical significance between TCM group and TCM and Western therapy group after treatment (P<0.05). The total effective rate of TCM group was 96.67% (29/30), 100.00% (30/30) of Western therapy group, 76.67% (23/30) of TCM and Western therapy group, with statistical significance (P<0.05). After three-month treatment, 1, 0 and 11 cases relapsed in TCM group, TCM and Western therapy group and Western therapy group, respectively, with statistical significance (P<0.001). Compared with the Western therapy group, the number of colds in the TCM group and TCM and Western therapy group significantly decreased (P<0.05). Compared with before treatment, IgE decreased significantly (P<0.05). There was no significant difference in EOS among the three groups before and after treatment (P>0.05). After treatment, the maximum expiratory flow in TCM and Western therapy groupwas higher than that before treatment and lower than that in the Western therapy group (P<0.01), and the other lung function indexes were not statistically significant (P>0.05). 1 mild adverse reaction was found in the TCM and Western therapy, and no obvious adverse reactions were found in other groups (P<0.05).ConclusionTiaozhong Yifei Prescription has good clinical efficacy for CVA.

Objective To study the correlation between serum thioredoxin 1(TRX-1)and nucleotide-bind-ing oligomerization domain-like receptor protein 3(NLRP3)expression levels and functional dyspepsia(FD)in children.Methods A total of 45 children with FD who were admitted to Shijiazhuang Maternal and Child Health Hospital from May 2022 to June 2023 were enrolled as the FD group.Another 40 healthy children were selected as the control group.Real-time fluorescence quantitative PCR was used to measure the expression lev-els of serum TRX-1 and NLRP3 mRNA.Spearman correlation analysis was used to analyze the correlation be-tween the expression levels of serum TRX-1 mRNA,NLRP3 mRNA and FD related scores.Multivariate Lo-gistic regression was used to analyze the influencing factors of FD.Results The expression levels of TRX-1 mRNA and NLRP3 mRNA in FD group were higher than those in control group(P＜0.05).The mild and moderate FD groups had significantly lower serum TRX-1 mRNA and NLRP3 mRNA expression levels than the severe FD group,and the mild FD group had significantly lower serum TRX-1 mRNA and NLRP3 mRNA expression levels than the moderate FD group(P＜0.05).The expression levels of TRX-1 mRNA and NLRP3 mRNA in serum were positively correlated with egigastric pain,abdominal distension or epigastric discomfort,nausea and vomiting(P＜0.05),but were not correlated with early satiety,loss of appetite or food intake,and belching(P＞0.05).The expression level of serum NLRP3 mRNA was positively correlated with the total score(P＜0.05),while the expression level of serum TRX-1 mRNA was not correlated with the total score(P＞0.05).The increased levels of serum TRX-1 mRNA and NLRP3 mRNA were independent risk factors for FD(P＜0.05).Conclusion The expression levels of TRX-1 and NLRP3 may play an important role in the pathogenesis of FD.

Objective:To explore the research hotspot and trends of home rehabilitation exercise for patients with Parkinson's disease.Methods:Literature related to home-based rehabilitation exercises for Parkinson's disease patients included in the core set of Web of Science database from establishment of databases to March 31, 2023 was retrieved. The source countries, institutions, authors, key words and references of the literature were visually analyzed by CiteSpace software, and the scientific knowledge map was drawn.Results:A total of 472 articles were included, and the annual publication volume was increasing year by year. The top three countries in terms of publication volume were the United States (176 articles) , the United Kingdom (54 articles) and Australia (54 articles) . The top three institutions with the highest number of publications were La Trobe University, Catholic University of Leuven and Radboud University. The research in this field mainly focused on randomized controlled trials and Meta-analysis. The initial stage of the research mainly focused on the effect of Parkinson's disease on the body, later transferred to gait research, and in recent years, began to focus on the application of virtual reality technology in the home-based rehabilitation of Parkinson's disease patients.Conclusions:Home-based rehabilitation exercises for Parkinson's disease patients can be carried out in many ways, but it is limited by disease symptoms and other influencing factors. Virtual reality technology, telemedicine, wearable devices and other technologies can promote the development of home-based rehabilitation exercises. It is necessary to increase the research efforts of such technology in the future and explore comprehensive home-based rehabilitation exercises programs.

Objective To investigate the changes and clinical significance of serum monocyte chemoattractant protein-1(MCP-1)and prostaglandin E2(PGE2)levels in children with functional dyspepsia(FD).Methods A retrospective study was conducted to enroll 89 FD children admitted from October 2022 to October 2023 as FD group,and 91 healthy children in the same period were se-lected as control group.The FD group was further divided into mild group(n=36),moderate group(n=33),and severe group(n=20)based on the severity of the disease.The serum levels of MCP-1 and PGE2 were detected by enzyme-linked immunosorbent assay(ELISA).The severity of the disease was assessed by the Global Overall Symptom Score(GOSS),and gastric emptying was evaluated in all the children.Pearson and Spearman correlation analyses were performed to explore the correlations of serum MCP-1 and PGE2 levels with gastric half-emptying time and FD symptom scores.Results The serum MCP-1 level in the FD group was significantly higher than that in the control group,while the PGE2 level was significantly lower(P＜0.05).In the severe group,the serum MCP-1 level was significantly higher while the PGE2 level was significantly lower than that in the moderate and mild groups,and similar differences were significantly observed between the moderate and mild groups(P＜0.05).The gastric half-emptying time and postprandial 2-hour residual rate were significantly higher in the FD group than the control group(P＜0.05).Serum MCP-1 in FD children was posi-tively correlated with gastric half-emptying time and postprandial 2-hour residual rate(P＜0.05),while serum PGE2 was negatively correlated with these parameters(P＜0.05).Serum MCP-1 in FD children was significantly positively correlated with upper abdominal burning sensation,early satie-ty,belching,upper abdominal pain,and the total GOSS score(r=0.611,0.509,0.504,0.491,0.513;P＜0.05),while PGE2 was significantly negatively correlated with upper abdominal burn-ing sensation,early satiety,belching,upper abdominal pain,acid reflux,and GOSS total score(r=-0.516,-0.561,-0.493,-0.533,-0.497,-0.482;P＜0.05).Conclusion Ele-vated serum MCP-1 and decreased PGE2 levels in children with FD are closely related to the severity of the disease,gastric emptying,and some FD symptoms.

Objective To investigate the changes and clinical significance of serum monocyte chemoattractant protein-1(MCP-1)and prostaglandin E2(PGE2)levels in children with functional dyspepsia(FD).Methods A retrospective study was conducted to enroll 89 FD children admitted from October 2022 to October 2023 as FD group,and 91 healthy children in the same period were se-lected as control group.The FD group was further divided into mild group(n=36),moderate group(n=33),and severe group(n=20)based on the severity of the disease.The serum levels of MCP-1 and PGE2 were detected by enzyme-linked immunosorbent assay(ELISA).The severity of the disease was assessed by the Global Overall Symptom Score(GOSS),and gastric emptying was evaluated in all the children.Pearson and Spearman correlation analyses were performed to explore the correlations of serum MCP-1 and PGE2 levels with gastric half-emptying time and FD symptom scores.Results The serum MCP-1 level in the FD group was significantly higher than that in the control group,while the PGE2 level was significantly lower(P＜0.05).In the severe group,the serum MCP-1 level was significantly higher while the PGE2 level was significantly lower than that in the moderate and mild groups,and similar differences were significantly observed between the moderate and mild groups(P＜0.05).The gastric half-emptying time and postprandial 2-hour residual rate were significantly higher in the FD group than the control group(P＜0.05).Serum MCP-1 in FD children was posi-tively correlated with gastric half-emptying time and postprandial 2-hour residual rate(P＜0.05),while serum PGE2 was negatively correlated with these parameters(P＜0.05).Serum MCP-1 in FD children was significantly positively correlated with upper abdominal burning sensation,early satie-ty,belching,upper abdominal pain,and the total GOSS score(r=0.611,0.509,0.504,0.491,0.513;P＜0.05),while PGE2 was significantly negatively correlated with upper abdominal burn-ing sensation,early satiety,belching,upper abdominal pain,acid reflux,and GOSS total score(r=-0.516,-0.561,-0.493,-0.533,-0.497,-0.482;P＜0.05).Conclusion Ele-vated serum MCP-1 and decreased PGE2 levels in children with FD are closely related to the severity of the disease,gastric emptying,and some FD symptoms.

Objective:To retrieve, evaluate and summarize relevant evidence on home-based exercise management in patients with mild to moderate Parkinson's disease, so as to provide reference and guidance for clinical healthcare professionals to construct and improve patient home-based exercise intervention plans.Methods:According to the top-down principle of the "6S" evidence model, UpToDate, BMJ, National Institute for Health and Clinical Excellence, Guidelines International Network, National Guideline Clearinghouse, Medlive, Clinical Guidelines Network, Joanna Briggs Institute, Cochrane Library, PubMed, CINAHL, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang Data, VIP and China Biology Medicine Disc were systematically searched for relevant literature on home-based exercise management in patients with Parkinson's disease, including guidelines, expert consensuses, systematic reviews, evidence summaries, clinical decisions, recommended practices and best practices. The search period was from the establishment of the databases to October 31, 2022. Two researchers independently evaluated the quality of the literature and extracted and integrated evidence.Results:A total of 27 articles were included, including three guidelines, five expert opinions and consensuses, three clinical practice suggestions, 15 systematic evaluations and one clinical decision. A total of 45 pieces of evidence were summarized from six aspects, such as organizational management, health education, exercise evaluation, exercise prescription, family and social support and monitoring guidance.Conclusions:This study summarized the best evidence of home-based exercise management for patients with mild to moderate Parkinson's disease, which can provide evidence-based basis for clinical staff to formulate home-based exercise management programs and standardize practice standards.