1.The association of endocrine-disrupting chemicals exposure, sociodemographic factors, and polycystic ovarian syndrome among reproductive-aged nonpregnant women at the Philippine General Hospital: A case–control study
Erlidia Flores Llamas-Clark ; John Robert Carabeo Medina ; aria Esterlita Tagle Villanueva-Uy ; Francisco M. Heralde III ; Maria Stephanie Fay Samadan Cagayan ; Paulyn Jean Buenaflor Rosell-Ubial ; Michael C. Velarde
Philippine Journal of Obstetrics and Gynecology 2024;48(3):151-161
BACKGROUND:
Polycystic ovarian syndrome (PCOS) is a prevalent condition affecting women of reproductive age, characterized by metabolic, endocrine, and reproductive disturbances including insulin resistance, abnormal uterine bleeding, infertility, and hyperandrogenism, and is associated with diabetes and cardiovascular disease. The etiology of PCOS is unclear and exposure to endocrine-disrupting chemicals (EDCs) present in everyday products may play a role by disrupting hormonal pathways.
OBJECTIVES:
To determine the association between exposure to EDC-containing products, sociodemographic factors, and PCOS diagnosis among nonpregnant reproductive-aged women.
MATERIALS AND METHODS:
A survey assessed the frequency of EDC exposure in homes and workplaces. The Rotterdam Criteria were used for the diagnosis of PCO features with clinical history and ultrasound. The association between PCOS and EDC exposure was determined using Chi-square and logistic regression analysis.
RESULTS:
The study identified significant sociodemographic factors associated with PCOS (P < 0.001) including age, civil status, and household income. Increased likelihood of PCOS was linked to frequent use of scented candles (odds ratio [OR] = 2.07), cleaning sprays (OR = 2.28), and floor polish (OR = 2.07), exposure to new upholstered furniture (OR = 4.00), thermal receipts (OR = 2.16), and consumption of microwaved and processed foods (OR = 2.60), as well as water sourced from wells (OR = 7.69). Additional associations were found with access to public markets (OR = 0.26) and the use of paper food wrappers (OR = 1.72).
CONCLUSION
These findings suggest that frequent exposure to EDC-containing products and certain sociodemographic factors may contribute to the development of PCOS among women of reproductive age. Results underscore the importance of reducing exposure to EDCs to prevent or mitigate the development of PCOS and other reproductive consequences.
Female
2.Risk determination of COVID-19 among unvaccinated nonpregnant women in Metro Manila, Philippines: A multicenter longitudinal cohort study
Erlidia Flores Llamas‑Clark ; Francisco M. Heralde III ; Mayan U. Lumandas ; Maria Esterlita T. Villanueva‑Uy ; Leilani C. Chavez‑Coloma ; Eleyneth I. Valencia ; Cynthia U. Anzures ; Maria Lu D. Andal ; Carolina Paula C. Martin ; Vanessa D. De Guzman ; Ryan B. Capitulo ; Arlene R. Dominguez ; Abygail L. Recio ; Jeremiah Francisco Feliciano ; Paulyn Jean Buenaflor Rosell‑Ubial ; Emmanuel S. Baja ; Maria Stephanie Fay Samadan Cagayan
Philippine Journal of Obstetrics and Gynecology 2023;47(6):302-311