OBJECTIVE: To investigate the effects of sildenafil citrate (Viagra) on the vertebral artery blood flow of patients with vertebro-basilar insufficiency (VBI) using color duplex sonography (CDS). MATERIALS AND METHODS: The study included 21 patients with VBI (aged 31-76; mean 61.0 +/- 10.5 yrs). We administered a 50 mg oral dose of sildenafil citrate to all patients. Next, we measured the peak systolic velocity (Vmax), end diastolic velocity (Vmin), resistive index (RI), pulsatility index (PI), diameter, area, and flow volume (FV) of vertebral arteries using CDS before the administration of sildenafil citrate; 45 minutes after, and 75 minutes after administration. Statistical testing was performed using SPSS for windows version 11.0. The statistical test used to determine the outcome of the analysis was the repeated measures analysis of variance (ANOVA) test. RESULTS: Compared to the baseline values, the vertebral artery diameter, area, and FV increased significantly following the administration of sildenafil citrate. The diameter, area and FV increased from 3.39 mm at 45 minutes to 3.64 mm at 75 minutes, 9.43 cm2 to 10.80 cm2 at 45 minutes and 10.81 cm2 at 75 minutes, as well as from 0.07 L/min at baseline to 0.09 L/min at 45 minutes and unchanged at 75 minutes, respectively. CONCLUSION: Sildenafil citrate elicited a significant effect on vertebral artery diameter, area and FVs.
Adult ; Aged ; Blood Flow Velocity/drug effects ; Female ; Humans ; Male ; Middle Aged ; Piperazines/*pharmacology ; Pulsatile Flow/drug effects ; Purines/pharmacology ; Sulfones/*pharmacology ; *Ultrasonography, Doppler, Color ; Vascular Resistance/drug effects ; Vasodilator Agents/*pharmacology ; Vertebral Artery/*drug effects/physiopathology/ultrasonography ; Vertebrobasilar Insufficiency/*physiopathology/ultrasonography