Objective:To compare the efficacy and safety of broad-band intense pulsed light (OPT-IPL) versus narrow-band intense pulsed light (DPL) in the treatment of rosacea-associated erythema and telangiectasia.Methods:Fifty-four rosacea patients who received treatment with intense pulsed light were collected from Laser Department, Hospital of Dermatology, Chinese Academy of Medical Sciences from October 2016 to December 2019, and clinical data were retrospectively analyzed. Their age ranged from 19 to 56 years, and disease duration ranged from 0.2 to 10 years. Of the 54 patients, 22 were treated with OPT-IPL, and 32 were treated with DPL. All patients completed at least one session of treatment and follow-up. Therapeutic efficacy was evaluated by using clinician erythema assessment (CEA) and physician global assessment (PGA) scales, and adverse reactions were assessed. A generalized linear mixed model was used to analyze differences in CEA and PGA scores among different groups and treatment sessions.Results:In the OPT-IPL group, 22, 17 and 10 cases completed 1, 2 and 3 sessions of treatment respectively, with the energy fluence being 16.57±1.21 J/cm 2. In the DPL group, 32, 25 and 16 cases completed 1, 2 and 3 sessions of the treatment respectively, with the energy fluence of 9.76±0.61 J/cm 2. Before the start of treatment and after 1, 2 and 3 sessions of treatment, the CEA scores were 2.38±0.84, 2.29±0.75, 1.94±0.66 and 1.90±0.66 respectively in the OPT-IPL group, and 2.25±0.77, 2.16±0.77, 1.84±0.81 and 1.47±0.81 respectively in the DPL group. As far as the CEA score was concerned, there was no interaction between the groups and treatment sessions ( F=0.57, P=0.638) , and no significant difference between the OPT-IPL group and DPL group ( F=0.84, P=0.360) , but a significant difference was observed among different sessions of treatment ( F=17.90, P< 0.001) , and the CEA score gradually decreased along with the increase of treatment sessions compared with that before treatment (all P< 0.05) . After 1, 2 and 3 sessions of treatment, the PGA scores were 0.39±0.71, 0.82±0.92 and 0.55±0.80 respectively in the OPT-IPL group, and 0.61±0.77, 1.34±1.09 and 1.53±1.38 respectively in the DPL group. As far as the PGA score was concerned, there was no interaction between the groups and treatment sessions ( F=1.62, P=0.202) , and no significant difference between the OPT-IPL group and DPL group ( F=3.93, P=0.050) , but there was a significant difference among different sessions of treatment ( F=19.33, P< 0.001) . Compared with the PGA score after 1 session of treatment, the PGA score gradually increased along with the increase of treatment sessions (all P< 0.001) . After treatment, no adverse reactions, such as blisters and crusts, occurred in either of the 2 groups, and there was no significant difference in the incidence of pigmentation, erythema aggravation, papules or increase in papule count between the 2 groups (all P> 0.05) . Conclusion:The efficacy and safety of DPL are comparable to those of OPT-IPL in the treatment of rosacea-related erythema and telangiectasia, but lower energy fluence is required.

Based on the first hand cardiothoracic surgical training experiences in Australia, the author introduced the Australian surgical training system's objective, structure, outline and specific training methods as well as its contents in detail. Its overall characters can be summarized as high standard, strict requirement and equal stress on both theory and practice. Hopefully, this introduction and reflection may shed some light on the improvement and evolvement of the resident training system in China.

OBJECTIVETo evaluate the association of MnSOD single nucleotide polymorphisms (SNPs) with the susceptibility to nasopharyngeal carcinoma (NPC) in Cantonese.

METHODSA total of 105 Cantonese NPC patients and 136 age-matched healthy controls were enrolled in this study. Genotyping of the SNP Ala-9Val of MnSOD gene was performed by PCR and direct sequencing of the PCR products.

RESULTSThe allele frequency of Ala in Cantonese was 19.1%. The frequencies of Val/Val, Val/Ala, and Ala/Ala genotypes were 83.8%, 14.3%, and 1.9% in NPC patients and 80.9%, 16.9%, and 2.2% in healthy individuals, respectively. No significant differences were found in the allele or genotype frequencies between NPC patients and controls. Ala/Val genotype was shown to be significantly less frequent in patients with a positive lymph node status, but the allele Ala was not correlated to lymph node involvement. No significant differences were found in the allele and genotype frequencies in patients with different tumor sizes, metastatic statuses, clinical statuses and histological types.

CONCLUSIONMnSOD Ala-9Val polymorphism can be region- and race-related, and it is not correlated to the genetic susceptibility of NPC in Cantonese.

Adolescent ; Adult ; Aged ; Carcinoma ; Case-Control Studies ; China ; epidemiology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; epidemiology ; genetics ; Polymorphism, Single Nucleotide ; Superoxide Dismutase ; genetics ; Young Adult

Objective:To evaluate the efficacy and safety of narrow-band intense pulsed light in the treatment of erythromelanosis follicularis faciei et colli (EFFC).Methods:The patients with EFFC, diagnosed at the Department of Cosmetic Laser Surgery, Hospital for Skin Disease, Chinese Academy of Medical Sciences, and Peking Union Medical College, from January 2017 to December 2022, were retrospectively evaluated. There were 28 patients, including 24 males and 4 females. They ranged in age from 15 to 35 (21.0±4.2) years. All patients received three sessions of narrow-band intense pulsed light treatments, with intervals of 1-2 months. A follow-up visit was completed 1-2 months after three treatments, and efficacy was evaluated. Two dermatologists assessed the clinical improvement in erythema, pigmentation, and follicular papules on a 4-point scale (0=0-25% improvement, 1=26%-50% improvement, 2=51%-75% improvement, and 3=76%-100% improvement). Adverse events were also recorded.Results:A total of 28 patients received three sessions of narrow-band intense pulsed light treatments and were followed-up. After three treatments, the mean improvement scores for erythema, follicular papules, and pigmentation were (2.02±0.65), (1.38±0.59) and (0.80±0.61) respectively. Among these patients, 67.9% (19/28) experienced over 50% improvement in erythema, 39.3% (11/28) showed over 50% improvement in follicular papules, and 7.1% (2/28) demonstrated over 50% improvement in pigmentation. No blisters and scars were formed.Conclusions:Narrow-band intense pulsed light is a safe and effective treatment for patients with EFFC, particularly for those presenting with erythema.

The frozen section (FS) technology has been widely used in the process of surgical pathology since its time-saving nature exhibited superiority over traditional paraffin method. Therefore FS, of great value in providing preliminary pathological diagnosis, offers guidance in the extension of surgical resection. However, it remains controversial whether the early-stage lung adenocarcinoma could be accurately identified in FS. This review aims to generalize the studies concerning the accuracy of FS in identifying early-stage lung adenocarcinoma, analyzing the interference factors, comparing the similarities and differences between frozen sections and traditional paraffin sections. It also gives insight into whether FS can provide significant guidance for surgeons to perform resection on early-stage lung adenocarcinoma.