1.Outcomes of hepatic metastasectomy for colorectal cancer metastases in the Philippine General Hospital.
Juan Carlos R. Abon ; Ramon L. De Vera ; A&rsquo ; Ericson B. Berberabe ; Marc Paul J. Lopez
Philippine Journal of Surgical Specialties 2021;76(2):48-55
RATIONALE:
The liver is the most common site of metastasis from
colorectal cancer. Curative intent liver metastasectomy has shown
improvement in overall survival. This manuscript will present
the long-term oncologic outcomes of hepatic metastasectomy for
colorectal cancer with resectable liver metastasis.
METHODS:
Data of patients with resectable liver metastases from
colorectal cancer who underwent hepatic resection at the Philippine
General Hospital over a 10-year period was reviewed. The primary
outcome investigated was overall survival.
RESULTS:
Thirty patients were included in the study. The median
overall survival was 20 months, with a 2-year and 5-year overall
survival rate of 40% and 6.67% respectively. Eleven (36.67%)
patients had disease recurrence, with a median disease-free survival
of 16 months. A significant difference in survival was seen between
patients with synchronous and metachronous liver metastasis (20.38
and 36.78 months respectively, p=0.0393) and in patients given
adjuvant chemotherapy at any time in relation to the occurrence of
the liver metastases versus patients who did not receive any adjuvant
treatment (34.08 and 18.59 months respectively, p=0.0349). Trends
towards improved overall survival were seen in patients 50 years
old or less (36.86 versus 21.78 months, p=0.0837) and in patients
with a clinical risk score of 2 or less (29.65 versus 19.62 months,
p=0.1823), which may show significance in a higher powered study
CONCLUSION
Improved overall survival was observed among patients
with colorectal liver metastases undergoing hepatic metastasectomy
compared to no liver resection.
Metastasectomy
;
Philippines
2.Hemosuccus pancreaticus: A case of upper gastrointestinal bleeding arising from a pancreatic pseudoaneurysm
Juan Carlos R. Abon ; A&rsquo ; Ericson B. Berberabe
Acta Medica Philippina 2023;57(3):66-70
Pancreatic pseudoaneurysms are possible complications of chronic pancreatitis. These may present as hemosuccus pancreaticus, a rare cause of upper gastrointestinal tract bleeding where a pseudoaneurysm erodes into an adjacent pseudocyst or pancreatic duct, manifesting as bleeding through the pancreatic duct into the duodenal papilla. We report a case of a 32-year-old male with a history of chronic pancreatitis presenting as intermittent upper gastrointestinal tract bleeding secondary to hemosuccus pancreaticus from a pancreatic pseudoaneurysm. The patient underwent multiple sessions of endovascular embolization, which successfully controlled the bleeding despite some failed attempts; thus, a potentially morbid last-resort surgery was avoided.
pseudoaneurysm
;
chronic pancreatitis
3.Current epidemiology of periampullary malignancies in a tertiary referral center in the Philippines: A five-year review
Juan Carlos R. Abon ; A&rsquo ; Ericson B. Berberabe
Acta Medica Philippina 2022;56(14):61-70
Background:
Periampullary malignancies traditionally occur during the later decades of life, but casual observations at the Philippine General Hospital (PGH) have shown more patients presenting at younger ages. Updates on the epidemiology and clinical features of these uncommon cancers may improve detection and result in better outcomes.
Objective:
The study aimed to describe the current epidemiology of adult patients diagnosed with periampullary malignancies seen in the past five years at the PGH Department of Surgery.
Methods:
Demographic and clinical data were obtained on patients with either pancreatic head, ampullary, distal bile duct, or duodenal cancer diagnosed from 2015 to 2019. Age and sex distributions, rates of symptom presentation, utilization of diagnostic modalities, and prevalence of comorbid conditions were analyzed per individual primary site and for the entire study population.
Results:
Two hundred seventy-seven patients were included in the study, comprised mostly of pancreatic head cancers (56.32%) followed by ampullary (19.86%), duodenal (9.75%), and distal CBD cancers (7.58%). The mean age of presentation was 59.30 years. 33.94% of cases occurred in the 6th decade of life, while 24.91% of patients were aged 50 years and below. There was a nearly equal distribution by sex (50.90% female, 49.10% male). Majority of patients presented with jaundice (89.65%) and abdominal pain (71.64%). CT scan was used to diagnose 71.48% of patients. We observed a higher prevalence of diabetes mellitus (21.32%), biliary stone disease (19.12%), and smoking history (36.88%) in the study group compared to the general Philippine population.
Conclusion
The epidemiology of periampullary malignancies at UP-PGH showed a younger age at presentation and an equal sex ratio compared to published data. Distributions of the primary sites, symptom frequency, and rate of associated comorbidities were consistent with previous findings from the literature.
Epidemiology
4.Pattern of weight loss after successful enucleation of an insulin-producing pancreatic neuroendocrine tumor
Mark Anthony Santiago Sandoval ; Tom Edward Ngo Lo ; A&rsquo ; Ericson Berberabe ; Mark Anthony De Lusong ; Juan Maria Ibarra Co
Journal of the ASEAN Federation of Endocrine Societies 2015;30(2):160-163
We report the case of a patient with hypoglycemic symptoms and weight gain. Biochemical investigations revealed endogenous hyperinsulinemic hypoglycemia. A CT scan and MRI of the abdomen were initially not successful in localizing a pancreatic mass. However, an endoscopic ultrasound was able to demonstrate a pancreatic head mass. Enucleation of the mass resulted in clinical and biochemical improvement. This report also demonstrates the pattern of weight loss after surgery, showing an initial phase of gradual weight loss followed by a rapid loss of weight. This pattern of weight loss after successful removal of an insulin-producing pancreatic neuroendocrine tumor is a novel addition to the existing knowledge we have about this condition.
Hypoglycemia
;
Insulinoma
;
Weight Loss
5.Disability weight determination for road traffic injuries in the Philippines: Metro Manila scenario.
Noel R. JUBAN ; Hilton Y. LAM ; Ruzanne M. CARO ; Jorge M. CONCEPCION ; Tammy L. DELA ROSA ; AEricson BERBERABE ; Karen June P. DUMLAO
Acta Medica Philippina 2019;53(1):73-79
Objective: To determine the Disability Adjusted Life Year (DALY) weights of road traffic injuries and use the DALY weights in determining the total DALYs lost in Metro Manila using available data.
Methods: Consensus on DALY weights for each of the 31 International Classification of Diseases (ICD)10 codes related to road traffic injuries was done using Delphi Process. Experts from different fields were invited to participate in 2 rounds of discussion-and-scoring were done to obtain consensus were obtained for each DALY weight. Philippine Health Insurance Corporation (PHIC) data on the counts of the 31 ICD 10 coded claims for the years 2011, 2012, and 2013 were obtained and used to calculate the total DALY lost due to vehicular injuries for Metro-Manila.
Results: Road traffic related injuries affected mostly young people (mean 34 yo + 15) and affected mostly men (81%). There were a total of 3,199 injuries seen in 2,573 patients. 98.1% of the patients had a < 1 year type of injury with an average disability weight of 0.34154 and a total DALYs lost of 300.4. 0.5% of the patients had a ? 1 year type of injury with an average disability weight of 0.2726 and a total DALYs lost of 218.08.1.4% of the patients most likely died from their injuries earning a total DALYs lost of 1,440.The sum of DALYs lost is equivalent to a total of 1,958.12.
Conclusion: The Metro Manila loses roughly Php 76.6 Million per year due to road traffic injuries and accidents. These events are highly preventable. Without proper interventions, road traffic injuries may lead to impoverishment of the young families who pick up the pieces, or are left behind.
Human ; Quality Of Life