1.Three new anthraquinone derivatives isolated from Symplocos racemosa and their antibiofilm activity.
Umar FAROOQ ; Sara KHAN ; Sadia NAZ ; Ajmal KHAN ; Afsar KHAN ; Ayaz AHMED ; Abdur RAUF ; Syed Majid BUKHARI ; Shujaat Ali KHAN ; Arfa KAMIL ; Nadia RIAZ ; Abdur Rahman KHAN
Chinese Journal of Natural Medicines (English Ed.) 2017;15(12):944-949
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, H- and C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis. Both compounds were further screened for anti-biofilm activity, which revealed promising activities at sub-MIC concentrations. None of the compounds were found to be active against Klebsiella pneumoniae.
Anthraquinones
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chemistry
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isolation & purification
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pharmacology
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Anti-Bacterial Agents
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chemistry
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isolation & purification
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pharmacology
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Biofilms
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drug effects
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growth & development
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Ericales
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chemistry
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Methicillin-Resistant Staphylococcus aureus
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drug effects
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physiology
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Microbial Sensitivity Tests
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Proteus mirabilis
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drug effects
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physiology
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Spectrophotometry, Infrared
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Streptococcus mutans
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drug effects
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physiology