Lucilia sericata larval secretions have bacteriostatic and bactericidal effects. We investigated the effect of L. sericata larval secretions during passage from the third to the second stage on Leishmania tropica under in vitro and in vivo conditions. The L. sericata larvae and their secretions were also used in the treatment of cutaneous leishmaniasis lesions. A total of 29 patients were included in this study. Seven patients were infected with Glucantime-resistant Leishmania major. In 22 patients, there was no information about the Glucantime resistance status and infection with L. tropica or L. major. All patients were efficiently treated with L. sericata larvae and their secretions without leaving scar tissue. Additionally, after 1-2 months of treatment, Leishmania spp. was not detected in the samples using PCR.

BACKGROUND/AIMS: It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle. METHODS: Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and response to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled water was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10-6, 10-5, 10-4, and 10-3 M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured. RESULTS: The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth intervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval. Even though muscles tones were not different in both groups during all intervals, it was remarkable that the muscle tone was significantly decreased in the rabeprazole group during the fourth interval compared to the first and second intervals. CONCLUSIONS: In the present study, high doses of rabeprazole reduced contraction frequencies, maximum contraction values, and muscle tone of human pylorus.
Baths ; Carbachol ; Humans ; Muscle Tonus ; Muscle, Smooth ; Muscles ; Proton Pump Inhibitors ; Pylorus* ; Rabeprazole* ; Relaxation ; Stomach Neoplasms ; Water