The enzyme histochemistry method was used in this experiment to study the biocompatibility of the UV surface modified Dacron. The activity of the enzymes such as ALP, ACP, NADHD and LDH in the tissue surrounding both the modified and unmodified materials after a certain implantation period was semiquantitatively measured. The results showed that the biocompatibility of the surface modified Dacron was as good as that of the unmodified one.
Biocompatible Materials ; Heart Valve Prosthesis ; Materials Testing ; Polyethylene Terephthalates ; radiation effects ; Surface Properties ; Ultraviolet Rays

Mechanical environment seems to be one of the most important surviving environment for vessel conduit and vascular endothelial cells(ECs), while adhesion is one of the most important physical characteristics of ECs. In this study, Flow chambers of steady laminar and turbulent flow are made and improved. Different flow-derived VCAM-1, ICAM-1 expressions are detected by laser confocal microscope. Spacial and temporal curves of the adhesion molecules are protracted. In laminar flow, expression of VCAM-1 is dramatically elevated, whereas the expression of ICAM-1 is transiently elevated and it immediately falls back to the baseline. In turbulent flow, expression of VCAM-1 declines, while expression of ICAM-1 slowly rises to a peak. These results indicate that such pathological flow field as turbulence exerts different influence on the adhesion of vascular ECs from laminar flow, and turbulence could be one of the most important reasons of the ECs structural and functional lesion.
Cell Adhesion ; Cells, Cultured ; Endothelium, Vascular ; cytology ; metabolism ; Epithelial Cells ; cytology ; metabolism ; Humans ; Intercellular Adhesion Molecule-1 ; biosynthesis ; Microscopy, Confocal ; Stress, Mechanical ; Umbilical Veins ; cytology ; Vascular Cell Adhesion Molecule-1 ; biosynthesis