3.Clinicopathological analysis of EB virus-positive mucocutaneous ulcer.
X ZHANG ; X G ZHOU ; M YANG ; Y MIAO ; R G XING ; Y Y ZHENG ; Y L ZHANG ; J L XIE
Chinese Journal of Pathology 2023;52(10):1037-1039
6.Advances in pathologic diagnosis of lymphoma.
Chinese Journal of Pathology 2005;34(6):322-324
7.Clinical Therapy and Prognostic Analysis of 61 Patients with Secondary Hemophagocytic Syndrome.
Journal of Experimental Hematology 2016;24(2):580-583
OBJECTIVETo investigate the relationship between the etiology, laboratory findings and prognosis of secondary HPS, so as to enhance the understanding of the secondary HPS and the related factors affecting prognosis, reduce the misdiagnosis and to understand the factors that affect the prognosis.
METHODSThe etiology, laboratory findings and prognosis of 61 patients with secondary HPS were analyzed retrospectively.
RESULTSUnivariate analysis showed that TG, FIB, SF, ANC, ALB, TBIL, ALT, LDH were significantly different between the 2 groups of the patients with secondary HPS. Multiariate factor analysis showed that the LDH and the etiology affected the prognosis of the patients with secondary HPS. The prognosis of the patients with elevated LDH, viral infection, especially EB virus infection, tumor and unknown causes might be poor.
CONCLUSIONSThe etiology and clinical characteristics of prognosis are diverse. The cause needs to be identified as soon as possible. The prognosis should be judged according to LDH and other indicators. Then, targeted therapy should be used to control the disease in the short time.
Epstein-Barr Virus Infections ; pathology ; Herpesvirus 4, Human ; Humans ; Lactate Dehydrogenases ; blood ; Lymphohistiocytosis, Hemophagocytic ; diagnosis ; pathology ; Neoplasms ; Prognosis ; Retrospective Studies
8.Morphological Characteristics of Bone Marrow Cells in Patients with EB Virus Infection.
Li-Yan HE ; Zheng YANG ; Chun-Ni HUANG ; Jian HUANG
Journal of Experimental Hematology 2022;30(3):908-912
OBJECTIVE:
Review and analyze the characteristics of bone marrow cell morphology in patients with Epstein-Barr virus (EBV) infection, and explore the diagnostic value of bone marrow cell morphology for the early identification of EBV infection.
METHODS:
A total of 33 patients with EBV-DNA positive detection in the First Affiliated Hospital of Guangxi Medical University from January 2018 to May 2021 were collected as the research objects. Bone marrow cell morphology and peripheral blood cell analysis were performed, and the significance in disease diagnosis was analyzed by statistical methods.
RESULTS:
The sampling satisfaction of 33 patients with EBV infection was 100%. In the clinical diagnosis of all cases, 7 cases were IM, 17 cases were EBV-HLH, 3 cases were lymphoma, 2 cases were EBV-associated lymphoid hyperplasia, and 4 cases were not diagnosed. Among them, 31 patients had active bone marrow hyperplasia or above, 26 patients had active granulocytic hyperplasia or above, 21 patients had active erythroid hyperplasia or above, and 17 cases of megakaryocyte production platelet function decreased. The abnormal components of bone marrow mainly indude atypical lymphocyte cells (33 cases), hemophagocytic cells (22 cases), abnormal histiocyte (10 cases).
CONCLUSION
According to the proliferation of granulocytes, erythrocytes and megakaryocytes in the bone marrow, and the emergence of abnormal components such as atypical lymphocytes, hemophagocyte, abnormal histiocyte. Bone marrow cell morphological examination can indicate the possibility of EBV infection, which is certain diagnostic value for early identification of EBV infection.
Bone Marrow Cells
;
Bone Marrow Diseases/pathology*
;
China
;
Epstein-Barr Virus Infections
;
Herpesvirus 4, Human
;
Humans
;
Hyperplasia/pathology*
Result Analysis
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