Surgery for temporal lobe epilepsy refractory to medical treatment is a promising treatment option. After a short overview on historical developments in this field, we describe the present practice of presurgical evaluation and resection strategies as practiced at our institution and review the corresponding publications from other centers. We try to delineate major future developments for surgical therapy of temporal lobe epilepsy, as they can derived from present trends.
Epilepsy, Temporal Lobe* ; Temporal Lobe*

Background & Objective: Psychiatric disorders constitute a large part of illness burden in patients with refractory epilepsy. A careful presurgical psychiatric assessment is now an integral part of evaluation in most centers performing surgeries for refractory epilepsy. This study was undertaken to determine the prevalence of psychiatric disorders and outcome of the psychopathology in patients of refractory mesial temporal lobe epilepsy (mTLE) before and after epilepsy surgery. Method: Forty eight patients diagnosed as having refractory mTLE by the Neurologists were included in the study. The patients were assessed using the Brief Psychiatric Rating Scale (BPRS), Beck’s Depression Inventory (BDI), Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) before surgery as well as in the second and sixth month of postoperative period. Results: More than half of the patients (54%) had psychopathology. Depressive disorders were more common. Lateralisation of focus in MTS and psychopathology in the patient revealed equal right and left preponderance. No significant difference was found on BPRS, BDI and HDRS scales at 2 and 6 months follow up post epilepsy surgery in patients having psychopathology. Conclusions: Patients had a favourable outcome after surgery as regards to their psychopathology as well as the seizures.
Epilepsy, Temporal Lobe

No abstract available.
Epilepsy, Temporal Lobe* ; Hippocampus* ; Parturition* ; Temporal Lobe*

No abstract available.
Anxiety* ; Depression* ; Epilepsy, Temporal Lobe* ; Temporal Lobe*

No abstract available.
Epilepsy, Temporal Lobe ; Humans ; Temporal Lobe

No abstract available.
Epilepsy, Temporal Lobe* ; Humans ; Temporal Lobe*

No abstract available.
Codon, Nonsense* ; Epilepsy, Temporal Lobe* ; Temporal Lobe*

Spitting as an ictal phenomenon has rarely been reported. It is considered to indicate a seizure onset in the nondominant temporal lobe. Three cases with ictal spitting were found in 81 consecutive patients who underwent temporal lobe resections due to intractable temporal lobe epilepsy. Two had evidence of the right temporal ictal onset. One had the left temporal ictal onset, but the Wada test demonstrated language dominance in the right hemisphere. Three all had mesial temporal sclerosis. One had recollection of her episodes of spitting with a gustatory aura, whereas the other patients had no awareness of this symptom. These cases support previous studies suggesting that spitting is a lateralizing sign to nondominant temporal lobe epilepsy.
Epilepsy ; Epilepsy, Temporal Lobe* ; Humans ; Sclerosis ; Seizures ; Temporal Lobe*

Hippocampal sclerosis is the most common abnormal pathologic substrate found in patients with intractable temporal lobe epilepsy. Histopathological findings of hippocampal sclerosis are characterized by the presence of neuronal cell loss and astrocytic proliferation in the facsia dentata, Ammon's horn, presubiculum, and subiculum. Despite numerous studies having been conducted, the pathogenesis of hippocampal sclerosis is still controversial. Recently, it has been reported that increased numbers of corpora amylacea can be found in the hippocampus, the gray and white matter of the temporal lobe, in association with hippocampal sclerosis, which may give another clue to the pathogenesis of the hippocampal sclerosis. The authors report 3 patients with medically intractable temporal lobe epilepsy with hippocampal sclerosis in association with an increased numbers of corpora amylacea in the temporal white matter.
Epilepsy ; Epilepsy, Temporal Lobe* ; Hippocampus ; Humans ; Neurons ; Sclerosis ; Temporal Lobe*

We have studied the clinical correlations between duration of epilepsy and anticonvulsant treatment response in temporal lobe epilepsy. We evaluated correlations between the duration of epilepsy before control and frequencies after six and twelve months of antiepileptic drug treatment, respectively. And we analyzed differences of epilepsy duration between no recurrence group, reduced seizure frequencies below 25% of before control frequencies and reduced seizure frequencies above 25% of before control frequecies groups respectively. We concluded that there are no positive correlations between the duration of epilepsy and seizure frequencies after antiepileptic drug treatment (Spearman correlation coefficients 0.2801 p=0.354 at six months antiepileptic drug treatment, 0.2797 p=0.355 at twelve months). We also concluded that there are no differencies of epilepsy duration between no recurrence group, group with reduced seizure frequencies below 25% of before control frequencies and group with reduced seizure frequencies above 25% of before control frequecies after six months of antlepileptic drug treatment(p=0.6511)and after twelve months of antiepileptic drug treatment (p=0.9469).
Epilepsy* ; Epilepsy, Temporal Lobe* ; Recurrence ; Seizures ; Temporal Lobe*