2.Research progress and stress-induced variation of DNA methylation in plants.
Zhen YANG ; Xuanming PENG ; Yiyan ZHANG ; Yuanhai ZHANG ; Yong ZHANG
Chinese Journal of Biotechnology 2016;32(12):1642-1653
Chemical modification of DNA bases in recent years has been one of the hot areas of life science research. DNA methylation is a common epigenetic phenomenon and can change the genetic performance without changing the DNA sequence. Various stress factors can induce the variation of DNA methylation in plants, but the response mechanism is still unknown. In this paper, the progress of DNA methylation in plants was reviewed. In combination with the researchconclusions of our own research group, the DNA methylation variation induced by 7Li ion beam and gamma ray was reported to provide a basis for DNA methylation, which may be involved in the phenotypic plasticity of plants.
DNA Methylation
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Epigenesis, Genetic
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Epigenomics
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Plants
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genetics
4.Let -7i : A key player and a promising biomarker in diseases.
Journal of Central South University(Medical Sciences) 2023;48(6):909-919
MicroRNAs (miRNAs) are endogenous non-coding single-stranded small RNAs that regulate gene expression by recognizing homologous sequences and interfering with transcriptional, translational or epigenetic processes. MiRNAs are involved in a variety of disease processes, and regulate the physiological and pathological status of diseases by modulating target cell activity, migration, invasion, apoptosis, autophagy and other processes. Among them, let-7i is highly expressed in various systems, which participates in the process of tumors, cardiovascular and cerebrovascular diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases and other diseases, and plays a positive or negative regulatory role in these diseases through different signal pathways and key molecules. Moreover, it can be used as an early diagnosis and prognostic marker for a variety of diseases and become a potential therapeutic target. As a biomarker, let-7i is frequently tested in combination with other miRNAs to diagnose multiple diseases and evaluate the clinical treatment or prognosis.
Biomarkers
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Apoptosis
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Autophagy
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Epigenesis, Genetic
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MicroRNAs/genetics*
8.Recent progress on miRNAs in the pathogenesis of colon cancer.
Jie-ting TANG ; Jing-yuan FANG
Chinese Journal of Medical Genetics 2008;25(3):297-299
microRNAs (miRNAs) are endogenous, small noncoding RNA molecules discovered in animals, plants and viruses. They play a critical role in developmental and physiological processes and are implicated in the pathogenesis of many human cancers. Presently, human cancer, including colorectal cancer, is recognized as both a genetic and epigenetic disease. Changes induced by miRNAs are considered as epigenetic changes. Experiments were largely performed to analyze the colorectal microRNAome and bio-networking involving miRNAs. This review focuses on recent advances in colorectal miRNA expression profiles. Further, we discuss the regulatory network of miRNAs in the initiation and carcinogenesis of colon cancer in order to open up an avenue of anticancer therapy based on the epigenetic regulation by miRNAs.
Animals
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Colonic Neoplasms
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genetics
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Epigenesis, Genetic
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genetics
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Humans
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MicroRNAs
;
genetics
9.Progress in Association between Genetic Correlation and Human Violent Behavior.
Hui LI ; Lei LI ; Hong-mei XU ; Zi-qin ZHAO ; Wen-bin LIU ; Huai-gu ZHOU
Journal of Forensic Medicine 2015;31(5):381-386
Human violent behavior is a complex behavior which is influenced by genetic and environmental factors. There is a trend in investigating the mechanism of violent behavior by using the genetic methods. This article reviews several candidate genes and advances in epigenetics which are associated with violent behavior. The prospects and significance of violent behavior research from the view of gene polymorphism and epigenetics are also discussed.
Aggression
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Epigenesis, Genetic
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Forensic Genetics
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Humans
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Polymorphism, Genetic
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Violence