Warty dyskeratoma (WD) is a rare epidermal tumor that frequently arises as a papule or nodule on the head or neck of middle-aged or older persons. Histologically, it shows a cup-shaped keratin-filled invagination of an acanthotic epidermis, suprabasilar clefting with villi projecting into the clefts and acantholytic dyskeratotic cells are also present. The changes almost always involve a single hair follicle. We describe a distinctive case of WD that showed involvement of two adjoining follicles within a solitary lesion.
Epidermis ; Hair Follicle ; Head ; Humans ; Neck

Pemphigus vulgaris is an autoimmune blistering disease that commonly involves the scalp. Lesions of pemphigus vulgaris that persist on the scalp for a long period may be accompanied by tufted hair folliculitis. Only two previous accounts of tufted hair folliculitis developing in a lesion of pemphigus vulgaris have been reported. We report a 51-year-old-man with erosions and clusters of hair on the scalp. The scalp lesion had persisted for about 20 years. A histopathological examination of the skin lesion on the scalp revealed separation of the epidermis and clusters of several adjacent hair follicles. The patient was diagnosed with persistent pemphigus vulgaris of the scalp showing features of tufted hair folliculitis.
Blister ; Epidermis ; Folliculitis ; Hair ; Hair Follicle ; Humans ; Pemphigus ; Scalp ; Skin

We report two cases of recurrent extramarnmary Pagets disease after wide local excision. Both cases involved the scrotum and the penoserotal junction, respectively. On histopathological examination, we could observed many Paget cells confined to the epidermis and the hair follicle, but not invading the underlying dermis in both cases. There was no evidence of internal malignancy. Both cases were treated with wide local reexcision.
Dermis ; Epidermis ; Hair Follicle ; Paget Disease, Extramammary* ; Scrotum

No abstract available.
Epidermis* ; Psoriasis

Hair follicle nevus is one of several nevi, in which hair and hair follicle are involved. Crowding of numerous tiny but mature hair follicles with thick fibrous root sheath are the characteristie histologic finding of the nevus. The patient was one month old male infant with pedunculated. mass l cm in size on the left preauricular area. Histologically the skin of the lesion is covered by acanthotic epidermis. In the corium are numerous small mature hair follicles with thick fibrous sheath and a few small Iobules of sebaceous gland embedded in a fibrovascular stroma. There are, however, no central plate of cartilage and adipose tissue.
Adipose Tissue ; Cartilage ; Crowding ; Dermis ; Epidermis ; Hair Follicle* ; Hair* ; Humans ; Infant ; Male ; Nevus* ; Sebaceous Glands ; Skin

Hypertrichosis is an overgrowth of hair not localized to the anclro en dependent areas of the skin. It may be congenital or acquired, localized or generalized localized hypertrichosis may occur in some types of pigrnentary nevi, chronic inflammation or irration, topical application of androgen or steroid, & localized myxedema. We report herein three i:ases of unilateral localized hypertrichosis with or without a brownish hyperpigmented patch developing on the face of a male adol scent. There are no known cau:,es of localized hyper trichosis. Histopath logically, it is characterized by increased melaniii pigment in the basal layer of the epidermis & enlarged hair follicles containing coarser liair. Electron microscopic findings show normal size & number of melanosomes in both mela nocytes & keratinocytes. Our cases differ frorn BecLers nevus in both clinical & histopatholcgic characteristics.
Epidermis ; Hair ; Hair Follicle ; Humans ; Hypertrichosis* ; Inflammation ; Keratinocytes ; Logic ; Male ; Melanosomes ; Myxedema ; Nevus ; Skin

A 26-year-old Korean woman had a 5 month history of pruritic, keratotic papules on the scalp, trunk, and pubic area, which were accompanied by diffuse hair loss from the scalp, eyebrows and pubic area. She also had flat-topped violaceous papules on the scalp and pubic area, and white lace-like striae on the oral mucous and hard palate. Histopathologic study of the progressive stages of the disease revealed dilated follicles filled with horny material, hyperkeratosis, hypergranulosis and hydropic degeneration of the basal cell layer. Throughout the entire subepidermal region, there was an intense bandlike infiltration of mononuclear cells, which were most prominent at the lower pole of the hair follicles. The late stage of the disorder showed atrophy of the epidermis and atrophy of the hair follicles with fibrotic tracts, and mild mononuclear infiltrate at the sites of the former hair follicles. This is the first recorded case, to the best of cur knowledge, in Korea.
Adult ; Atrophy ; Epidermis ; Eyebrows ; Female ; Hair ; Hair Follicle ; Humans ; Korea ; Lichens* ; Palate, Hard ; Scalp

BACKGROUND: Desmocollins (Dsc) are calcium-dependent transmembrane glycoproteins of desmosomes that are important in the junction complex of epidermis and maintain structural integrity of the skin from external stressors. Among three Dscs (Dsc 1, 2, 3), Dsc 1 and 3 are distributed on skin. OBJECTIVE: The purpose of this study was to observe the Dsc 1 distribution pattern on the skin and oral mucosa during fetal development. METHODS: Skin was obtained from the sole and scalp of 33 fetuses, ranging from 10 to 37 weeks of gestational age. Immunohistochemical staining was performed on the paraffin-embedded tissue using a Dsc 1 monoclonal antibody. RESULTS: Dsc 1 was expressed in the suprabasal layer but not in the basal layer of the epidermis of the sole at the 10th week of gestation. Thereafter, Dsc 1 expression further increased in the suprabasal layer with initiation of stratification and increased gradually in the granular layers of the sole and scalp epidermis. Dsc 1 was strongly expressed in the superficial layer of the infundibulum and inner root sheath of the hair follicle but was not expressed in the sebaceous cells or other hair components. The eccrine duct epithelium was focally and weakly positive for Dsc 1 expression. Furthermore, Dsc 1 was not expressed in oral mucosa, although the oro-cutaneous portion was strongly expressed in the superficial layer. CONCLUSION: Dsc 1 was strongly expressed in the suprabasal cells of the epidermis during fetal skin development, and expression increased gradually in the granular layer and inner root sheath of the hair follicle. However, Dsc 1 was not expressed in basal cells or in oral mucosa. Dsc 1 may play a role in the maintenance of epithelial integrity as part of desmosomes.
Desmocollins ; Desmosomes ; Epidermis ; Epithelium ; Fetus ; Gestational Age ; Glycoproteins ; Hair ; Hair Follicle ; Mouth Mucosa ; Pregnancy ; Scalp ; Skin

Authors attempted to examine the development of keratinocyte in the human fetal epiderrnis in term of the appearance of principal product of differentiation, the keratins. Immunohistochemical study (ABC method) using anti-prekeratin antibodies and anti-keratin antibodies was carried out on sampled skin from 9 human fetuses ranging in estirnated gestational age from 12 weeks to 27 weeks. As early as 12 weeks of embryonic life, the epidermis contained cytokeratin. At this stage of development, the embryonic epidermis consists of three-cell layer .' basal layer, intermediate layer, and periderm, all of them staining for prekeratin and keratin. A thick cornified layer developed at 24 weeks but was not stained for prekeratin and keratin. Hair germ of 12 week-fetus was recognized as bulges of basal cells that were stained for prekeratin and keratin. At 18 weeks of estimated gestational age, development has advanced to the bulbous hair peg stage at which point the primordia of nearly all the final structural components of follicles were established. In the final structureal cornponents of the follicles, outer root sheath and sebaceous gland were stained for prekeratin and keratin, whereas cortical and cuticular elements and inner root sheath were negative. There was no difference between immunostaining results for prekeratin and keratin except for the staining intensity. The appearance of these proteins early in development suggests their potential value in utero in the recognition of keratinization disorders.
Antibodies ; Epidermis* ; Fetus* ; Gestational Age ; Hair Follicle* ; Hair* ; Humans* ; Keratinocytes ; Keratins ; Sebaceous Glands ; Skin

The Hairless (HR) gene regulates the expression of several target genes as a transcriptional corepressor of nuclear receptors. The hair follicle (HF), a small independent organ of the skin, resides in the epidermis and undergoes regenerative cycling for normal hair formation. HF development requires many genes and signaling pathways to function properly in time and space, one of them being the HR gene. Various mutations of the HR gene have been reported to cause the hair loss phenotype in rodents and humans. In recent studies, it has been suggested that the HR gene is a critical player in the regulation of the hair cycle and, thus, HF development. Furthermore, the HR gene is associated with the Wnt signaling pathway, which regulates roliferation and differentiation of cells and plays an essential role in hair and skin development. In this review, we summarize the mutations responsible for human hair disorders and discuss the roles of the HR gene in HF development.
Epidermis ; Hair ; Hair Follicle ; Humans ; Phenotype ; Receptors, Cytoplasmic and Nuclear ; Rodentia ; Skin ; Wnt Signaling Pathway