Two hundred and thirteen cases of acute poisoning who were admitted in pediatric wards of Severance Hospital and Won ju Christian Hospital from April, 1966 to March, 1976 (10 years) were statistically analyzed and compared it with the statistical study of same hospitals from April, 1956 to March, 1966 (10 years). 1. Incidence of poisoning was 1.2% of all admitted cases. Severance Hospital and Won ju Christian Hospital were corresponding to 0.9% and 2.0% of all pediatric admitted patients respectively 2. Sex incidence was more higher in boys than girls, The highest incidence (39%) was noted in the 1 to 4 year age group. 3. Seasonal incidence was more prevalent in summer months. (form June to August) 4. Fortyseven kinds of various poisonous substances were observed to be causative. The most common causative was insecticide (made for aggricultual use) which was 52% of all cases. (Severance Hospital: 37%, Won ju Christian Hospital: 76%). Drug (23%), CO gas (8.5%) and rodenticide (5%) were the next common causative agnts. 5. Poisoning of accidental cause was frequent (69%) than therapeutic and suicidal purpose, which were 26% and 6% respectively. 6. Mortality rate was 8% and insecticide was the most common cause of death. 7. There was no statistically significant difference between the past study and this study which were performed from two same hospitals in sex incidence, age incidence, seasonal distribution, motivations of poisoning, duration from poisoning to arrival to emergency room and mortality rate. In the past study the most common causative substance was CO gas in Severance Hospital and insecticide in Won ju Christian Hospital. In this study insecticide become the most common causative substance in both hospitals and the incidence was significantly increased than the past. Drug was second common causative agent. Lye was markedly decreased poisoning to compare with past study. Incidence of patients who were treated at the other clinic was increased from 14% to 33%.
Cause of Death ; Emergency Service, Hospital ; Female ; Gangwon-do ; Humans ; Incidence ; Infant* ; Lye ; Mortality ; Poisoning ; Seasons ; Statistics as Topic

There is a broad range of lumbar pedicular and neural arch anomalies, with spina bifida occulta and spondylolysis being especially common. It is very rare for a pedicular cleft to be associated with contralateral spondylolysis in the same vertebral segment. We observed L4 spondylolisthesis, clefting of the left L4 hypertrophied pedicle associated with contralateral spondylolysis, and spinal stenosis on a radiographic study of the lumbar spine. Operative treatment was performed, with posterior decompression, partial removal of the hypertrophied pedicle, posterior lumbar interbody fusion using a cage, and posterior instrumentation. The patient's neurologic symptoms resolved after operative treatment. Fusion of the left pedicle cleft was observed on 6-month follow-up CT. We report one case of pedicular cleft fusion using pedicle screw fixation and present a review of the relevant literature.
Decompression ; Follow-Up Studies ; Neurologic Manifestations ; Spina Bifida Occulta ; Spinal Stenosis ; Spine ; Spondylolisthesis ; Spondylolysis

No abstract available.

No abstract available.
Humans* ; Ligamentum Flavum*

Intermittent administrations of dopaminergic agents in hemiparkinsonian rat enhances the behavioral response to subsequent administration of the drugs. This phenomenon is known as "priming" and thought as comparable to drug-induced dyskinesia in patients with Parkinson's disease. We investigated the behavioral and electrophysiological changes in 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rats after repeated administrations of apomorphine. Administration of apomorphine (0.32 mg/kg, intraperitoneal, i.p.) twice daily for 6 days enhanced the rotation induced by apomorphine from 341 turns/hour at the beginning to 755 turns/hr at the end. At the same time, the response to selective D2 agonist quinpirole (0.26 mg/kg, i.p.) was also enhanced from 203 to 555 turns/hr. Extracellular single unit recording revealed no significant difference in the basal firing rates of substantia nigra pars reticulata (SNr) neurons between the ipsilateral and contralateral side of the 6-OHDA lesion regardless of the repeated administrations of apomorphine. In SNr of the lesion side, the units with burst firing pattern were found more frequently after repeated administrations of apomorphine and the suppressive effect of quinpirole on the firing rate was enhanced. These findings suggest that the increased percentage of the burst units is the important electrophysiological change in the development of enhanced response to selective D2 agonist.
Animal ; Apomorphine/*pharmacology ; Dopamine Agonists/*pharmacology ; MPTP Poisoning/physiopathology ; Male ; Oxidopamine/toxicity ; Parkinsonian Disorders/*physiopathology ; Quinpirole/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D2/*drug effects ; Substantia Nigra/*drug effects/physiology

No abstract available.
Cerebellopontine Angle* ; Intraoperative Neurophysiological Monitoring* ; Neuroma, Acoustic*

This study was designed for the investigation of the effectiveness and limitation of the endovascular coil embolization of intracranial aneurysms. From July 1995 to October 1997, the authors treated 25 patients of intracranial aneurysm with endovascular coil embolization. There were 15 cases of ruptured aneurysms and 10 cases of unruptured aneurysms. The main reasons for the coil embolization were difficult anatomical location and poor neurological condition. Total 28 aneurysms were tried to embolize with coil. Among these, 12 aneurysms were occluded completely, 12 aneurysms partially, and 1 vertebral artery fusiform aneurysm was treated by coil occlusion of the proximal vertebral artery. The complete occlusion was possible in 10 cases of 15 small aneurysms(66.7%), and in 2 cases of 6 large aneurysms(33.3%). Only partial occlusion was achieved in all 3 giant aneurysms. Of 18 small neck aneurysms(4mm) could be occluded completely. There were 3 cases of failure, 2 cases being catherizatioin failure because of the tortuous vessel and 1 case due to local vasospasm. The complications related to the coil embolization were the perforation of the aneurysm caused by the catheterization in 2 cases, rebleeding after partial embolization of the aneurysm in 2 patients of Hunt-Hess grade 4 and 5, and infarction caused by parent vessel occlusion by coil protrusion in 2 cases. In conclusion, the coil embolization can be an alternative modality in the treatment of intracranial aneurysms. But the complete occlusion is not always possible in all cases, and the risk of the rebleeding is still remained in the partially occluded aneurysms. The long-term study is needed to confirm the definite effectiveness of the coil embolization in the treatment of intracranial aneurysms.
Aneurysm ; Aneurysm, Ruptured ; Catheterization ; Catheters ; Embolization, Therapeutic* ; Humans ; Infarction ; Intracranial Aneurysm* ; Neck ; Parents ; Vertebral Artery

For the primary fusion of adult's lumbar spondylolisthesis the authors performed either posterolateral fusion(PLF) with transpedicular screw fixation, or posterior lumbar interbody fusion(PLIF) with cages and transpedicular screw fixation, on 75 patients during five years between Jan. 1993 and Dec. 1997. The outcomes were retrospectively reviewed with emphasis on comparison of the results of these two surgical methods. Between patients treated with PLF(PLF group) and PLIF(PLIF group) there were no differences in distribution of preoperative variables such as patients' age and gender, type, level, grade of spondylolisthesis, and symptom durations. Mean follow-up period was 22.3 months in PLF group(n=44) and 17.4 months in PLIF group(n=31) (p<0.001). The rate of fusion was 85% in PLF group, and 94% in PLIF group(p=0.292). The postoperative outcome, expressed as mean follow-up score of Prolo scale, was 6.86 in PLF group and 7.42 in PLIF group(p=0.007). The variables that were associated with the outcomes were the level of spondylolisthesis(p=0.001) and the type of fusion (p=0.023). Variables such as age, gender, type and grade of spondylolisthesis, preoperative symptom duration, radiological findings of fusion status, change in disc height, and change in sagittal angle were not associated with the outcomes. The complication rate was 11% in PLF group and 19% in PLIF group. Overall successful results, defined by 7 or more in follow-up score of Prolo scale, were seen in 68% of PLF group and 87% of PLIF group(p=0.098). It is concluded that better surgical outcomes were obtained by PLIF methods in adults with lumbar spondylolisthesis, but with regards to the incidence of complications, although mostly minor and reversible, was more frequent in PLIF group.
Adult* ; Follow-Up Studies ; Humans ; Incidence ; Retrospective Studies ; Spondylolisthesis*

OBJECTIVE: To determine the effect of shunt devices on the surgical outcome in the idiopathic normal pressure hydrocephalus(NPH), the authors present a retrospective analysis of 39 elderly patients who underwent shunt operations between November 1994 and May 2000, retrospectively. METHODS: The patients enrolled in this study did not have the history of intracranial hemorrhage, head injury, infection, cerebral infarction and brain tumor. The mean age was 69.9(range:52-89) years. Thirteen patients who received operations with simple pressure-control shunt valves(Group I), 22 patients with siphon-control shunt valves(Group II), and four patients with flow-regulating shunt valves (Group III). Final outcome with the clinical improvement and shunt associated complications were evaluated at the last follow-up and the mean follow-up period was 14.7 months. RESULTS: Signs or symptoms of shunt dysfunction were found in eight of 39 patients(20.5%) in the subsequent course. In group I, five out of 13 patients had suffered from symptomatic subdural hematomas and one from overdrainage symptoms(46.2%);in group II, two out of 22 from underdrainage(9%);in group III, one out of four from symptomatic subdural hematomas(25%). Five patients required operative shunt revisions and five underwent burr-hole trephinations for subdural hematomas. Clinical improvements were observed in 10(79.6%), 19(86.4%), and 3(75%) patients in group I, II, and III respectively. Surgical outcomes were better for patients with siphon-control shunt valves than there with the other shunt valves in terms of shunt associated complications and functional improvements(p=0.05). CONCLUSION: The shunt operation with siphon-control shunt valves might be good for the elderly patients with idiopathic NPH.
Aged ; Brain Neoplasms ; Cerebral Infarction ; Craniocerebral Trauma ; Follow-Up Studies ; Hematoma, Subdural ; Humans ; Hydrocephalus, Normal Pressure* ; Intracranial Hemorrhages ; Retrospective Studies ; Ventriculoperitoneal Shunt

Selective arterial embolization can reduce the size and pressure whtihin the nidus of the arteriovenous malformations(AVMS) and diminish the number of feeding pedicles, making subsequent surgical excision technically easier and safer, especially in those AVM patients whose lesions are judged to be inoperable or respectable with major risk. Authors have successfully and repeatedly performed selective arterial embolizations with polyvinyl alcoholfoam(PVA foam) and isobutyl-2-cyanoacrylate(IBCA) to a large AVM at the left basal ganglia, thalamus and lateral ventricles, and a large cortical AVM near right motor strip.
Arteriovenous Malformations* ; Basal Ganglia ; Humans ; Lateral Ventricles ; Polyvinyls ; Thalamus