Unilateral adrenal hyperplasia (UAH) is a rare, surgically correctable subset of primary aldosteronism. It has similar clinical features to aldosterone-producing adenoma (APA), but different pathologic finding. We report a case of UAH in a 51-year-old Korean man. The patient had hypertension. Hypokalemia and suppressed plasma renin activity (PRA) with elevated plasma aldosterone concentration (PAC) was observed. The 1.5 cm-sized nodule in left adrenal gland was scanned by abdominal computed tomography (CT). The selective adrenal venous sampling for determinations of PAC showed an overfunctioning left adrenal gland, and laparoscopic left adrenalectomy was performed. Pathologically, 1.3 cm-sized nodular hyperplasia lesion was observed. Hypokalemia, hypertension, and endocrine data were corrected after surgery, and there was no sign of recurrence for eight months after surgery. Clinical features of UAH are also reviewed.
Adenoma ; Adrenal Glands ; Adrenalectomy ; Aldosterone ; Humans ; Hyperaldosteronism* ; Hyperplasia* ; Hypertension ; Hypokalemia ; Middle Aged ; Plasma ; Recurrence ; Renin