1.Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases.
Journal of Korean Medical Science 2010;25(2):333-335
This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately.
Adult
;
Antipsychotic Agents/*adverse effects
;
Clozapine/*adverse effects
;
Dopamine/metabolism
;
Dopamine Agonists/*therapeutic use
;
Drug Therapy, Combination
;
Enuresis/chemically induced/*drug therapy
;
Humans
;
Male
;
Middle Aged
;
Piperazines/*therapeutic use
;
Quinolones/*therapeutic use
;
Schizophrenia, Paranoid/drug therapy