Background. Nowadays more attention is paid to the study of blood supply of the brain in during headache with various causes. Blood supply of the branch is supplied by 2 pairs of carotis and vertebral artery and 2/3 of it in the carotis and 1/3 of it by the vertebral artery. (Farekas et al., 1963) disease with various causes of the vertebral artery in the external part of the cranium or abnormal system have been studied from ancient un the external part of the cranium, lengthening, aplasia and hypoplasia, change of neck vertebra disk affect to dynamic change of back artery blood supply. By scholar maisel fold of vertebral artery is 40%. Stenoses-18%, hypoplasia-10% vertebral artery through c 3-c5 vertebra occurred 12-20%., abnormal system of vertebral artery and location occur more than carotis artery and it has more dependence on external part of the cranium. Study of disease of vertebral artery in the external part of the cranium by the method of angiography hasnt been done in our country. Aim of research work: We aimed at diagnosing disease of vertebral artery in the external part by the method of angiography and studying its form, case, age and sex dependence. Conclusion: 1. Change of vertebral artery revealed 62.3% 2. Fold of vertebral artery in the 6th level 42% in v2, 3 level -9% revealed. 3. Vertebral artery is congenitally narrow (aplasia, hypoplasia)12%., through v3-5, vertebra-13%. 4. 58% of the people with vertebral artery disease occupy females.

Background. In the process of infarction, important mechanism of blood supply deficiency is collateral blood supply. There are a lot of various collaterals which are able to supply in the period of necessity of human brain. Collateral which forms in the level of villas circle (ring) in the cranium is the most important front and back artery cord of brain form villas circle (ligament) as a result of these arteries possibility of forming collateral blood supply in the period of blood insufficiency in vertebral and carotis and between magisterial artery of 2 sides of brain opens. It is rare when the system of villas circle (ring) is complete (full), artery cord is narrow (hypoplasia, aplasia) or none, villas circle(ring) loses its complete and it becomes open on the front and at the back part. By the researchers study hypoplasia of artery cord occurs in 20-40% because it branches off from other artery. By Yu.M. Nixitins study vertebral artery of the brain branches off the form the artery into carotis and it open at back part-was 25%, study of system of villas circle (ring) by angiography hasnt been done. Aim. We aimed at the diagnosing villas circle system by angiographic method and studying its incompleteness, form cause, age and sex dependence. Materials and Methods. We studied material of 595 patients who were done angiography of the brain because of acute and chronic deficiency of blood supply of the brain in 2007-2008 at the third clinical hospital by P.N.Shastin in the cabinet of angiography came from clinic, district and Achtan Elit hospital. We clarified magisterial arteries and villas circles in the cranium by the standard method in 2 sides used polydiagnostic 2 digital subtraction equipment of Philips form of Japan. We evaluated artery system, location, form and size and studied age and sex dependence.75% of verographer solution not more than 80-100ml was injected into the artery. Conclusion: 1. Incompleteness of circle revealed in 31.7 % 2. Open case of villas circle in the front part was in 41.5 % 3. Open case of villas circle at the back revealed in 58.4% 4. Studying villas circle, evaluating collateral blood supply is necessary to blood supply deficiency in particular to define blood deficiency insult.

Background. Disease of vertebralis and insufficiency of blood supply occur not a few, it decreases lab our ability much, complaints such as: headache, to feel giddy, to blur eyes, fatigue heartache, neck becomes stiff and unbalance reveal. By some researches study 25-30% of blood supply insufficiency of cranium occupies artery disease 65% of vertebral artery insufficiency occupies disease of external part of cranium we have introduced duplex sonography method by using medison Pico-ACE apparatus since 2006 and it gave possibility of revealing artery disease of external cranium. The most causes of artery disease occupy congenital and acquired deficiency such as: aplasia, hypoplasia and vertebra skin. Revealing and diagnosing these disease early is the confronted problem of society and health and it attracts attention of doctors and specialists of angioneurological branch. Aim of research work: We aimed at the study of diagnosing disease of artery of vertebral of external part of cranium by the method of duplex-sonography and studying dependence of type, size, form, case, age and sex. Materials and Methods. We did the study on 100 people who was done duplexsonographic diagnose because of blood supply insufficiency of cranium in the centre of diagnose of private structure Best Ema. We did analyse of DSG by using MedisonPicoACE apparatus by the stand and method, divided them into 6 groups in 10 age and studied type, size, location speed of stream, age and sex. Conclusion: 1. By duplex-sonography, in 18% hypoplasia of vertebral artery revealed, in 88.8% of it hemo-dynastic change revealed. 2. In 24% of patients involved in the study artery fold revealed, in 62.5 hemo-dynastic change revealed. 3. The main method of analyze which reveals location, size and dynamic and diagnosis vertebral artery of external part of cranium is DSG.

BACKGROUND: There are two general types of age-related macular degeneration: dry and wet. During wet or neovascular age-related macular degeneration new abnormal vessels grow and leak in the macula. As anti-vascular endothelial growth factor (anti-VEGF) was invented, it revolutionized the treatment of nAMD by inhibiting the progress of this disease. The incidence of AMD increases as life expectancy grows and there is a growing need to study this disease. We aimed to evaluate the outcome of anti-VEGF therapy for the treatment of nAMD and the incidence of ocular serious adverse events (SAE) after injections.. METHODS: In our retrospective, single-center study, medical records of patients receiving a single dose of anti-VEGF treatment (Bevacizumab) for nAMD between 17th of April, 2016 and October, 2017 were evaluated. Outcome measures were the change in the baseline visual acuity (VA) score at post-injective month one, incidence of ocular SAE and patients’ baseline characteristics affecting VA. Patients, whose treatment were started before April 2016 and had anti-VEGF treatment for the diseases other than nAMD, were excluded.. RESULTS: 15 eyes in 15 patients between 52 and 85 years of age received single dose of anti-VEGF (Bevacizumab/Avastin) injection. The mean baseline VA improved from pre-injective average of 0.21 to post-injective 1-month average of 0.37 by Snellen. Furthermore, there was no vision loss or other severe adverse effects, such as endophthalmitis, vitreous hemorrhage, retinal detachment, traumatic cataract after 4 weeks. CONCLUSION: Anti-vascular endothelial growth factor therapy has promising short-term outcomes on treating neovascular age-related macular degeneration.