OBJECTIVE: To study the mechanism of intestinal absorption of protocatechualdehyde .METHODS: Using invivo rat intestinal absorption model and HPLC, the apparent small intestine absorption rate of protocatechualdehyde was mea-sured. RESULTS: Under low, medium and high concentrations of drug, the apparent small intestine absorption rates of proto-catechualdehyde were 1.1 341/h, 1.1 637/h and 1.0 847/h respectively .CONCLUSION: The protocatechualdehyde absorptionmechanism is passive diffusion.

OBJECTIVE:To study the curative effects of Heart nourishing Granula on viral myocarditis(VMC)model mice.METHODS:The mice were randomly divided into treatment group and control group after intraperitoneal injected(inoculation)with a diluted solution of Coxsackie virus B 3 ,the general state and the mortality of which were observed.The blood sample and cardiac tissues of the mice were taken at different time after inoculated with virus for enzyme labeled com?pound assay,virus isolation test,light microscope test and transmission electron microscope test.RESULTS:The survival rate of the treatment group was higher than that of the control group.There was significant difference(P

OBJECTIVE： To investigate the possible role of the alteration of mitochondrial transmembrane potentials(Δ Ψ m) in arsenic trioxide(As2O3)-induced apoptosis of human gastric adenocarcinoma cells(SGC7901).METHODS： Cell apoptosis was assessed through morphology， cell viability， the percentage of sub-G1 cells and phosphatidylserine(PS) externalization.the Δ Ψ m was detected on flow cytometry through double staining of Rhodamine 123 (Rh123) and propidium iodide(PI).RESULTS： The As2O3-induced apoptosis was associated closely with the disruption of the Δ Ψ m.CONCLUSION： The disruption of the Δ Ψ m is one of the mechanisms of As2O3-induced apoptosis.

The blood vessels of the M.tensor fasciae latae,the iliotibial band and itsoverlying skin were dissected and measured in 30 lower limbs of 15 adult fresh ca-davers,the results were as follows:1.The branches of the lateral femoral circumflex artery may be classified intofour types:three-branch type(60.00%?8.94),dispersion type(20.00%?7.30),poly-branch type(10.00%?5.48)and two-branch type(10.00%?5.48).Amongthem,the three-branch type,which is divided into the ascending,transverse,anddescending branches,is the most common one.The caliber of the ascending branchis 2.22?0.09mm with a length of 2.70?0.22cm.The caliber of transverse branchis 2.16?0.07 mm with a length of 2.12?0.17cm.The caliber of descending branchis 2.87?0.11 mm with a length of 6.95?0.68cm.All of the three accompanyingveins consisted of vanae comitantes,the caliber and length of the vein are approxi-matly the same as those of the artery.2.The M.tensor fasciae latae is supplied by its main artery,which comes fromthe ascending branch of the lateral circumflex artery(90.00%?25.49).In a fewcases,it comes from the transverse branch(6.66%?4.55)or the deep femoralartery(3.33%?3.27).The caliber of the main artery of M.tensor fasciae latae is1.64?0.05 mm,and its length is 2.71?0.24 cm.The ascending branch and themain artery together make the vascular pedicle which length is 5.55?0.32 cm.Thecaliber and the length of the pedicle is large enough for ideal microsurgical vasanastomoses.3.The iliotibial band is supplied by the tractocutaneous artery,which comesfrom the perforating branch of myocutaneous artery of vastus lateralis and thedescending branches of lateral circumflex artery.It perforates the iliotibial bandand reaches to the subcutaneous tissues to supply the iliotibial band and its overly-ing skin.4.The skin territory of the M.tensor fasciae latae and iliotibial band issupplied by the pure cuteneous artery,the perforating branches of myocutaneousartery and the tracto-cutaneous artery.The main artery enters the muscle and sendsperforating branches into the overlying skin.All the three kinds of cutaneousarteries form abundant anastomoses in subcutaneous tissues.For this reason,if themain artery anastomoses with the artery of the host,an area in dimensions up to15?35 cm~2 of skin would survive in the anterolateral thigh.

OBJECTIVE:To discuss the thoughts over the event of“armillarisin A”produced by Qiqihar No.2Pharmaceut ical Co.Ltd.METHODS:Citing the event of“armillarisin A”produced by Qiqihar No.2Pharmaceutical Co.Ltd.as example,we analyzed problems occurred in the process of production and management of pharmaceuticals and traced the root causes.RESULTS&CONCLUSIONS:Pharmaceutical enterprises should bear in mind their social responsibility and leave no loophole in the control and supervision of drugs,they should draw lessons from this event and prevent the similar event from happening again by working out effective measures to tighten controls on the quality of drug production,registering and approval,circulation,ADR reporting,etc.

OBJECTIVE:To investigate the dissolution of DEHP in PVC infusion set and the packaged infusion sets of the Paclitaxel injection so as to evaluate the safety of clinical infusion sets for paclitaxel.METHODS:The packaged infusion sets of Paclitaxel injection were collected from 9 Three-A grade hospitals in Chongqing.Paclitaxel injections were prepared as per actual concentration needed by the clinic and dripped through eight different infusion sets(in which 7 were packaged infusion sets) for 3 h.The peak area of the collected solution was measured and its content was determined by HPLC,and the effect of infusion time on the dissolution of DEHP was investigated as well.RESULTS:The dissolution of DEHP dripped through eight infusion sets were 1 408,9 393,6 576.5,2 412.6,8 194.4,0,8 477.2,and 8 037.4 ?g,respectively.The dissolution increased with the prolonging of infusion time.CONCLUSION:At present,the majority of packaged infusion sets of Paclitaxel injection were made form PVC materials.The safe medication of Paclitaxel can't be ensured for the dissolved DEHP can enter the blood directly,thus its hazardness should be given great attention.

lecithin. No dissolution of DEHP was noted in lecithin. In a certain kind of surfactant, the dissolution of DEHP was positively correlated with the concentration of surfactant and the infusion time and the length of the infusion tube. CONCLUSIONS: The results serve as reference for the choice of safe infusion set when surfactants is contained in the injection and the choice of surfactant in the production of injection in pharmaceutical facoties.

OBJECTIVE:To establish the method for preparation of compound fluconazole eye drops and to determine the content of fluconazole in the preparation METHODS:Detection was performed by second order derivative spectrophotometry RESULTS:Linear relationship was found in the fluconazole concentrations ranging from 80?g/ml to 400?g/ml The regression equation was D=0 0 094+0 002C,r=0 9 998 The recovery of fluconazole was 99 83%(RSD=0 69%,n=5) CO_NCLUSION:The eye drops was stable The method of determination of the content is simple,rapid and reliable

OBJECTIVE:To study the effect of concentrations of alcohol in precipitation method on polysaccharide contents in order to optimize the extractive condition of Xinmaishen oral liquid METHODS:Taking the total polysaccharides in the decoction as target and dertermining the effective components by phenol-vitriol colorimetry,the effects of 4 alcohol concentrations(50%,60%,70%,80%) on polysaccharide contents were studied RESULTS:The results showed that the polysaccharide contents sharply decreased with the increase of alcohol concentration When the alcohol concentration reached 80%,the polysaccharide content lost nearly 70% CONCLUSION:Polysaccharide content should be used as one of exam indices in screening preparation technique of this oral liquid

OBJECTIVE:To explore the necessity of developing pharmaceutical services on the retailed pharma?cy.METHODS:The current state of the pharmacy retailers in China and the necessity of developing pharmaceutical services on the retailed pharmacy were analyzed.RESULTS&CONCLUSION:Only through developing specialized pharmacy services actively can the pharmacy retailer strengthen their competitive ability in the pharmacy market.