Objective: To explore the feasibility of clinical application of common day surgery in general surgery. Methods: From January 2018 to December 2018, the clinical data of 40 cases of gallbladder stones(LC group), 40 cases of breast lumps(breast lumps group) and 36 cases of mixed hemorrhoids(mixed hemorrhoids group) admitted to the daytime center of the First People's Hospital of Huainan were retrospectively analyzed.The average hospitalization days and expenses were analyzed, and each group was equally divided into control group(traditional surgery) and research group(day surgery). The hospitalization time and hospitalization expenses were compared between the control group and research group. Results: The hospitalization time of the research group in the LC group, breast lumps group and mixed hemorrhoids group was (21.07±6.31)h, (45.60±7.39)h, (21.07±6.31)h, respectively, which were significantly shorter than those of the control group[(106.80±25.20)h, (184.50±25.00)h, (236.00±54.14)h], the differences were statistically significant(t=15.093, 14.898, -15.645, all P<0.05). The hospitalization expenses of the research group in the LC group, breast lumps group and mixed hemorrhoids group were (2 083.01±436.04)CNY, (8 842.46±861.15)CNY, (3 186.47±464.93)CNY, respectively, which were also significantly lower than those of the control group[(3 594.82±1 059.60)CNY, (11 003.76±1 706.78)CNY, (6 419.69±817.45)CNY], the differences were statistically significant(t=5.245, 6.666, -16.082, all P<0.05). Conclusion Day surgery has obvious advantages and development space in clinical practice of common surgery in general surgery.It has incomparable effect and is superior to traditional surgery.