Objective Neutrophil/lymphocyte ratio (NLR) is a simple and reliable inflammation biomarker but few studies have assessed the relationship between NLR and hypertension in Chinese population. In order to evaluate how NLR is related to the incidence of hypertension, we designed a large scale prospective cohort study in an adult population. Method Participants were recruited from Tianjin Medical University's General Hospital?Health Management Centre. Hypertension?free subjects (men, 13 638;women,15 212) were followed up for a median of 2.7 years. Adjusted Cox proportional hazards regression models were used to assess relationships between the quintiles of NLR and the incidence of hypertension. Result During the follow-up period, 1 348 subjects in men and 476 subjects in women developed hypertension. The hazard ratios of hypertension incidence were evaluated in increasing NLR quintiles both in men and women. In the final multivariate models, the hazard ratios (95% confidence interval) for hypertension across NLR quintiles were 1.00 (Reference), 1.05 (0.87, 1.26), 1.02 (0.85, 1.22), 1.07 (0.90, 1.29) and 1.22 (1.03, 1.45) (P for trend=0.01), in men;1.00 (Reference), 1.11 (0.82, 1.49), 0.79 (0.58, 1.08), 1.13 (0.85, 1.52) and 1.25 (0.94, 1.66) (P for trend=0.07), in women, respectively. Conclusion This study showed that the elevated NLR levels were significantly related to an increased risk of developing hypertension in men, but not in women.

Objective:To investigate the clinical value of serum levels of secreted frizzled related protein 1 (SFRP1), D-dimer to fibrinogen ratio (DFR), Irisin in predicting prognosis in patients with acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) complicated with pulmonary embolism.Methods:Retrospectively AECOPD patients with concurrent pulmonary embolism admitted to the Wuhan No.1 Hospital from January 2021 to December 2023were selected, and divided into a survival group of 50 cases and a death group of 10 cases based on their survival outcomes during hospitalization. Comparing the general clinical data and serum levels of SFRP1, DFR, and Irisin between two groups of patients, a logistic regression model was used to analyze the correlation between the course of AECOPD, SFRP1, DFR, and Irisin levels and adverse prognosis in AECOPD patients with pulmonary embolism. Receiver operating characteristic (ROC) curves were plotted to analyze the value of SFRP1, DFR, and Irisin in predicting adverse prognosis in AECOPD patients with pulmonary embolism.Results:There was a statistically significant difference in the duration of AECOPD between the two groups of patients ( P<0.05). The differences in serum SFRP1, DFR, and Irisin levels between the two groups of patients were statistically significant (all P<0.05). The results of logistic regression analysis showed that SFRP1, DFR, and Irisin ( OR=1.022, 4.991, 0.719) were influencing factors on the prognosis of AECOPD patients with pulmonary embolism (all P<0.05). The ROC curve showed that the area under the curve (AUC) of SFRP1, DFR, and Irisin for predicting adverse prognostic outcomes in AECOPD patients with pulmonary embolism was 0.844, 0.920, and 0.842, respectively. Conclusions:SFRP1, DFR, and Irisin are influencing factors for poor prognosis in AECOPD patients with pulmonary embolism, and have high value in predicting the prognosis of AECOPD patients with pulmonary embolism.