1.Pathophysiological Role of Endothelin-1 and Clinical Usefulness of Endothelin Antagonists.
Korean Circulation Journal 1998;28(5):825-833
No abstract available.
Endothelin-1*
;
Endothelins*
2.Pathophysiological Role of Endothelin-1 and Clinical Usefulness of Endothelin Antagonists.
Korean Circulation Journal 1998;28(5):825-833
No abstract available.
Endothelin-1*
;
Endothelins*
3.Beyond Vasodilator: Anti-Apoptotic Effect of Endothelin Receptor Antagonist.
Korean Circulation Journal 2014;44(2):74-75
No abstract available.
Endothelins*
;
Receptors, Endothelin*
5.Endothelin-mediated Intracellular Calcium Mobilization in Cultured Bovine Corneal Endothelium.
Tae Won HAHN ; Seok Ho CHA ; Keon Haong LEE ; Jae Ho KIM
Journal of the Korean Ophthalmological Society 1999;40(1):31-39
To investigate the effect of endothelin on intracellular free calcium ([Ca(2+)]i) mobilization and the existence of the endothelin receptor in cultured bovine corneal endothelial cells(BCEC), endothelin-1(ET-1) -induced [Ca(2+)]i increase was measuredby using calcium sensitive indicator, fura-2/AM, and the studies on its desensitizaton and receptor antagonists were also performed. ET-1 increased [Ca(2+)]i in a concentration-dependent manner(10(-9)M-10(-5)M) and ET-1 -unduced [Ca(2+)]i transient increase was significantly ingibited (~50%) by the pretreatment with EGTA for 1 min. Similarly, neomycin also attenuated ET-1 -unduced [Ca(2+)]i transient increase in a concentration-dependent mannet. Desensitizatin study with successive treatment of ET-1 and ET-3, and the experiments of antagonists(BQ-610 for the ET(A) receptor and BQ-788 for the ET(B) receptor) showed the presence of ET(B) receptor in BCEC. In addition, ET-1(10(-6)M) accumulated inositol trisphosphate about two folds (310+/-6.8 cpm) comparing to control(154+/-11.6 cpm) and this accumulation was significantly inhibited by the treatment with neomycin (187+/-28 cpm). These results suggest that endothelin-induced calcium mobilization is receptor-mediated response and TE(B) receptor exists in BCEC.
Calcium*
;
Egtazic Acid
;
Endothelins
;
Endothelium, Corneal*
;
Inositol
;
Neomycin
;
Receptors, Endothelin
6.Changes in Plasma and Urine Endothelin Levels During Acute Exacerbation of Asthma.
Jung Hyun CHANG ; Tae Rim SHIN ; Ga Eun WOO ; Jong Seon KIM ; Eun Soon HONG ; Gi Yeoul SEO ; Joo Hyun CHA ; Mi Seon KIM ; Yeung Seon KIM ; Young Joo CHO
Tuberculosis and Respiratory Diseases 1997;44(4):844-852
BACKGROUND: Recent studies have documented increased release of endothelin(ET) during acute attack of asthma. The purpose of this study is to observe the link between plasma level and urinary excretion of each and changes during acute exacerbation. METHOD: Plasma and 24 hour urine were collected from sixteen asthmatics during acute exacerbation, twice ; first day of symptomatic exacerbation and two weeks after treatment. Controls were ten healthy normal subjects. All patients were treated with corticosteroid and beta-2 adrenergic agonist on admission. ET was determined by radioimmmunoassay and had 100% cross reactivity with ET-1, 67% with ET-2, 84% with ET-3, and 8% with Big-ET. RESULTS: Plasma ETs were significantly elevated during acute attack of asthma compared with those in remission and controls. However, there was no significant changes in urine ET concentrations or total ET amounts in 24 hour urine during exacerbation upto two weeks. Those levels of urine ET in asthmatics were still higher than controls. ET concentrations in plasma or urine were not correlated with pulmonary functional parameters and hypoxemia. CONCLUSION: The findings suggests that increased plasma ETs are related with exaggerated release during acute asthma. Urinary ET excretion is increased in asthma. However, urine ET changes during exacerbation should be observed in a larger and longer scale.
Adrenergic Agonists
;
Anoxia
;
Asthma*
;
Endothelin-2
;
Endothelins*
;
Humans
;
Plasma*
7.Comparison of Endothelin Release in Bronchial Asthma, Chronic Obstructive Pulmonary Disease and Healthy Controls.
Korean Journal of Medicine 1998;55(1):69-74
OBJECTIVE: Both bronchial asthma and chronic obstructive pulmonary disease(COPD) are defined as disease entities causing sudden exacerbation of dyspnea; the former is a reversible airflow obstruction and the latter partially reversible and characterized by slowly progressive airflow obstruction. There were several reports suggesting endothelin release during an acute exacerbation of asthma and COPD, however few report showed comparative data of asthma and COPD concomitantly. The author examined the release of endothelin in COPD in comparison with those in asthmatics and healthy controls. METHODS: Plasma and 24 hour urine were collected from 33 asthmatics and 13 COPDs during an acute respiratory exacerbation and from 10 healthy controls. Endothelin was determined by radioimmmunoassay. RESULTS: Plasma endothelins were elevated in asthma and COPD and there were no significant changes compared with controls. Endothelin excretion in 24 hour urine was significantly higher in asthma and COPD than in controls. Endothelin concentrations in 24 hour urine showed a negative correlation with FEV1. CONCLUSION: Endothelins in 24 hour urine were increased in acute exacerbation of asthma and COPD and these increases were negatively correlated with FEV1 significantly. These findings are interpreted that endothelin contributes to the pathogenesis of acute exacerbation in asthma and COPD.
Asthma*
;
Dyspnea
;
Endothelins*
;
Plasma
;
Pulmonary Disease, Chronic Obstructive*
9.The effects of angiotensin II and thrombin on the secretion of PDGF endothelin, and PGI2 in cultured umbilical vein endothelial cells
Kyoo Yul CHOO ; Tae Suk LEE ; Ho Chul PARK ; Soo Myung OH ; Jae Kyung PARK
Journal of the Korean Society for Vascular Surgery 1993;9(1):25-41
No abstract available.
Angiotensin II
;
Angiotensins
;
Endothelial Cells
;
Endothelins
;
Epoprostenol
;
Thrombin
;
Umbilical Veins
10.The Effect of Endothelin-1 on IOP and Aqueous Outflow Facility in the Rabbit Eye.
Woon Bong JWA ; Kyung Won YOO ; Sae Haun RHO
Journal of the Korean Ophthalmological Society 1996;37(1):129-135
Endothelin(ET) is known as a family of potent hydrophobic, vasoactive peptide. We investigated the effect according to the concentrations of ET on intraocular pressure(IOP), aqueous outflow facility, pupillary diameter and light reflex and iris vessels. Twenty-four hours after injection of 2.5 microgram and 10 microgram of ET-1 into the anteriorvitreous of rabbit eyes, the IOP was reduced by 69% and 80%, respectively and did not return to the level of prefreatment until at least 14 days and 20 days, respectively. But the decrease of IOP was not due to the increased aqueous outflow. The pupillary diameter of ET-1 treated eyes was 1 to 2mm larger than the pretreatment. The time course of the pupillary effects generally ran paralled with the reduction of IOP. The iridial and conjunctival hyperemia was detectable during the pupillary dilatation. Endothelins are therefore potential participants in the local regulation of IOP, ocular blood vessel tone, and iris smooth muscle tone.
Blood Vessels
;
Dilatation
;
Endothelin-1*
;
Endothelins
;
Humans
;
Hyperemia
;
Intraocular Pressure
;
Iris
;
Muscle, Smooth
;
Reflex