1.Pulmonary Metastases of Uterine Endometrial Stromal Sarcoma: Diffuse Micronodular and Ground Glass Opacities: A Case Report.
Gou Young KIM ; Chang Ohk SUNG ; Joungho HAN ; Joon Oh PARK ; Kyung Soo LEE
Journal of Korean Medical Science 2004;19(6):901-903
Pulmonary metastases of uterine endometrial stromal sarcoma (ESS) are un com-mon. The patterns of uterine ESS metastasis to the lung are multiple pulmonary nodules, single nodule, or cystic lesions. Pulmonary intraalveolar micronodular metastases of uterine ESS are unusual and have not been reported. We experienced a case of metastatic uterine ESS presenting as pulmonary diffuse micronodules with ground glass opacities on chest computed tomography of a 37-yr-old woman who previously underwent hysterectomy due to low grade ESS of the uterus four years ago. The histologic findings of video assisted thoracotomy biopsy showed numerous intraalveolar polypoid micronodules protruding from the alveolar septums. All tumor nodules were composed of short spindle cells arranged in ill-defined whorls, and nuclear feature and sparse cytoplasm were seen in uterine ESS. Immunohistochemically, these cells showed strong nuclear staining for estrogen receptor and progesterone receptor, and diffuse cytoplasmic staining for CD10.
Adult
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Endometrial Neoplasms/*pathology/radiography
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Female
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Humans
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Lung Neoplasms/*pathology/radiography/*secondary
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Sarcoma, Endometrial Stromal/*pathology/radiography/*secondary
2.The utility of the 3D imaging software in the macroscopic rendering of complex gynecologic specimens.
Luca RONCATI ; Beniamino PALMIERI ; Teresa PUSIOL ; Francesco PISCIOLI ; Michele SCIALPI ; Giuseppe BARBOLINI ; Antonio MAIORANA
Journal of Gynecologic Oncology 2015;26(2):168-169
No abstract available.
Abdomen/pathology/surgery
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Adult
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Endometrial Neoplasms/complications/*pathology/radiography/surgery
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Endometriosis/complications/*pathology/radiography/surgery
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Female
;
Humans
;
Image Enhancement/*methods
;
Imaging, Three-Dimensional/*methods
;
Pelvis/pathology/radiography/surgery
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Radiography, Abdominal
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Sarcoma, Endometrial Stromal/complications/*pathology/radiography/surgery
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*Software
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Specimen Handling
3.The morphologic features of endometrial stromal sarcoma and its metastases.
Ying DONG ; Xue-jun SHI ; Ting LI ; Ying ZHANG
Chinese Journal of Pathology 2005;34(3):163-166
OBJECTIVETo study the morphologic feature, immunohistochemistry phenotype of ESS and its metastases, with emphasis on the histogenesis, tumor differentiation and diagnostic criteria.
METHODSThe pathologic features of 15 cases and 4 metastases were studied. The immunohistochemical study was performed on selected sections by a panel of antibodies including CD10, smooth muscle actin, estrogen and progesterone receptors, keratin (AE1/3) and alpha-inhibin.
RESULTSPatients were 22 to 75 years of age (mean 45). The endometrial stromal component predomominated in 7 cases. Three cases showed a picture of smooth muscle differentiation. Endometrial stromal sarcoma with fibromyxoid features were present in 2 cases. There were 3 sarcomas of poorly differentiated. The morphology features of the metastatic foci in 3 of the 4 metastasis cases were not similar to that of the primary counterpart in uteri. Among 14 ESS and 4 metastases, 15 of 18, 5 of 18, 7 of 18, and 10 of 18 were positive for CD10, SMA, ER and PR, respectively. AE1/3 and alpha-inhibin were only positive in the adenomatous area of ESS. Strong expression of SMA was obtained in all 10 cellular leiomyomas, and CD10 was only weakly expressed in 1 case (P < 0.05).
CONCLUSIONSESS are morphologically heterogeneous with multipotential differentiation. The histologic features of the metastases may not be similar to those of the primary. CD10 and SMA are diagnostically useful markers for ESS.
Actins ; metabolism ; Adult ; Aged ; Cell Differentiation ; Endometrial Neoplasms ; metabolism ; pathology ; Female ; Humans ; Lung Neoplasms ; diagnostic imaging ; metabolism ; secondary ; Middle Aged ; Muscle, Smooth ; pathology ; Neoplasm Recurrence, Local ; Neprilysin ; metabolism ; Radiography ; Sarcoma, Endometrial Stromal ; metabolism ; secondary ; Uterus ; metabolism ; pathology
4.Establishment of a rabbit model bearing transplanted endometrial carcinoma and magnetic resonance imaging features of the metastatic lymph nodes.
Gang DUAN ; Yi-kai XU ; Ping DUAN
Journal of Southern Medical University 2008;28(9):1716-1719
OBJECTIVETo establish a rabbit model bearing endometrial carcinoma and observe the magnetic resonance imaging (MRI) features of the metastatic lymph nodes.
METHODSVX(2) tumor grafts were orthotopically embedded into the endometrium of the rabbits. Three weeks after the implantation, the tumor and the metastatic retroperitoneal lymph nodes were examined with MRI, and the signal intensities and the size of the lymph nodes were compared with those in normal rabbits.
RESULTSOrthotopic tumor growth was observed in all the rabbits. Tumor infiltration of the serosa and retroperitoneal lymph node metastasis occurred 3 weeks after tumor implantation. MRI demonstrated obviously lymph node enlargement in the tumor-bearing rabbits as compared with those of normal rabbits, while the signal intensity of the lymph nodes were comparable between them.
CONCLUSIONThe endometrial carcinoma in this rabbit model well simulate the metastatic behavior of human endometrial carcinoma, and may serve as a good model for testing the efficacy of the contrast agents for MRI of the lymph nodes.
Animals ; Cell Line, Tumor ; Disease Models, Animal ; Endometrial Neoplasms ; pathology ; Female ; Lymph Nodes ; diagnostic imaging ; Lymphatic Metastasis ; Magnetic Resonance Imaging ; Neoplasm Transplantation ; Rabbits ; Radiography