1.Response: Frequency of RAS Mutations and PAX8/PPARgamma Rearrangement in Follicular Thyroid Tumors in Korea.
Endocrinology and Metabolism 2012;27(3):252-253
No abstract available.
Korea
;
Thyroid Gland
2.Letter: Frequency of RAS Mutations and PAX8/PPARgamma Rearrangement in Follicular Thyroid Tumors in Korea.
Endocrinology and Metabolism 2012;27(3):251-251
No abstract available.
Korea
;
Thyroid Gland
3.1-34 PTH Could Reverse Impaired Bone Mineralization Induced By the Overdose of Bisphosphonate.
Kyeong Hye PARK ; Kwang Joon KIM ; Han Seok CHOI ; Kyoung Min KIM ; Eun Young LEE ; Seonhui HAN ; Hyun Sil KIM ; Daham KIM ; Hannah SEOK ; Eun Yeong CHOE ; Yumie RHEE ; Sung Kil LIM
Endocrinology and Metabolism 2012;27(3):247-250
Bisphosphonates are the mainstay of osteoporosis treatment. Despite the fact that bisphosphonates have a relatively good safety record and are tolerated well by the majority of patients, serious adverse events have been associated with their use. A 41-year-old man had been diagnosed with osteoporosis and had taken etidronate 200 mg/day daily for 2 years due to the judgmental error. He was referred for the management of refractory bone pain and generalized muscle ache. Serum calcium, phosphate, 25-hydroxy-vitamin D (25(OH)D), and immunoreactive parathyroid hormone (iPTH) were within normal range. Plain X-ray showed multiple fractures. Whole body bone scan confirmed multiple sites of increased bone uptakes. Tetracycline-labeled bone biopsy showed typical findings of osteomalacia. He was diagnosed with iatrogenic, etidronate-induced osteomalacia. The patient received daily parathyroid hormone (PTH) injection for 18 months. PTH effectively reverses impaired bone mineralization caused by etidronate misuse. Currently, he is doing well without bone pain. Bone mineral density significantly increased, and the increased bone uptake was almost normalized after 18 months. This case seems to suggest that human PTH (1-34) therapy, possibly in association with calcium and vitamin D, is associated with important clinical improvements in patients with impaired bone mineralization due to the side effect of bisphosphonate.
Adult
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Biopsy
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Bone Density
;
Calcification, Physiologic
;
Calcium
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Diphosphonates
;
Etidronic Acid
;
Humans
;
Judgment
;
Muscles
;
Osteomalacia
;
Osteoporosis
;
Parathyroid Hormone
;
Reference Values
;
Vitamin D
4.A Case of Diabetic Mastopathy.
Seok Hong LEE ; Bo Min KIM ; Jae Woong KIM ; Moon Ki HONG ; Seonghyeop HYEON ; Mi Yi KIM ; Jaetaek KIM ; Jihyun AHN
Endocrinology and Metabolism 2012;27(3):244-246
Diabetic mastopathy is an unusual fibroinflammatory breast lesion that is characteristically presented in premenopausal women with long-standing diabetes with multiple microvascular complications. This patient was a 49-year-old postmenopausal woman with diabetic nephropathy, neuropathy, and retinopathy. Although palpable mass was detected on the left breast, an ultrasonography could not distinguish it from breast cancer. Excisional biopsy was conducted. Histological findings indicated diabetic mastopathy with keloid-like fibrosis, perivascular lymphocytic infiltration, and lymphocytic lobulitis without evidence of malignancy. After excision, there has been no recurrence until now.
Biopsy
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Breast
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Breast Neoplasms
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Diabetic Nephropathies
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Female
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Fibrosis
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Humans
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Middle Aged
;
Recurrence
5.A Case of Ectopic ACTH Syndrome Associated with Metastatic Prostate Cancer.
Eun Ky KIM ; Soo Heon KWAK ; Hwa Young AHN ; Ah Reum KHANG ; Hyo Jin PARK ; So Yeon PARK ; Sang Eun LEE ; Hak Chul JANG ; Seong Yeon KIM ; Young Joo PARK
Endocrinology and Metabolism 2012;27(3):237-243
Ectopic adrenocorticotropic hormone (ACTH) syndrome is mostly associated with neuroendocrine tumors and small cell carcinoma of the lung. This syndrome of prostate cancer is rare and has been reported in only a few cases. We report a patient with ectopic ACTH production associated with metastatic prostate cancer. A 70-year-old patient with metastatic prostate cancer was admitted to our hospital with septic shock. He had a history of hormonal therapy and transurethral prostatectomy. Adrenocortical function was checked due to consistent fever and poor general condition, which revealed markedly increased levels of basal plasma ACTH and serum cortisol. The patient did not present typical signs of the Cushing's syndrome, however, hypokalemia and a history of hypertension were found. He died in days as a result of multi-organ failure. On pathology, the prostatectomy specimen showed a tumor composed of mixed populations of adenocarcinoma and small cell carcinoma. The tumor cells in the small cell component were positive for chromogranin and ACTH. Although neuroendocrine differentiation in prostate cancer is rare, etopic ACTH production should be considered in patients with prostate cancer as well as in clinical features of ACTH hypersecretion.
ACTH Syndrome, Ectopic
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Adenocarcinoma
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Adrenocorticotropic Hormone
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Aged
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Carcinoma, Small Cell
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Cellular Structures
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Cushing Syndrome
;
Fever
;
Humans
;
Hydrocortisone
;
Hypertension
;
Hypokalemia
;
Lung
;
Neuroendocrine Tumors
;
Plasma
;
Prostate
;
Prostatectomy
;
Prostatic Neoplasms
;
Shock, Septic
;
Transurethral Resection of Prostate
6.A Case of Adipsic Hypernatremia Associated with Anomalous Corpus Callosum in Adult with Mental Retardation.
Boo Gyoung KIM ; Ka Young KIM ; Youn Jeong PARK ; Keun Suk YANG ; Ji Hee KIM ; Hee Chan JUNG ; Hee Chul NAM ; Young Ok KIM ; Yu Seon YUN
Endocrinology and Metabolism 2012;27(3):232-236
Adipsic hypernatremia cause chronic hyperosmolality and hypernatremia through a combination of impaired thirst and osmotically stimulated antidiuretic hormone secretion. This syndrome can be grouped together as disorders of osmoreceptor dysfunction due to the various degrees of osmoreceptor destruction related with different types of intracranial lesions around the anterior hypothalamus, consistent with the location of primary osmoreceptor cells. Adipsic hypernatremia, associated with developmental disorder of corpus callosum, is very rare. Most cases are diagnosed at infancy and early childhood; the replacement of desmopressin is necessary. Herein, we report adipsic hypernatremia associated with anomalous corpus callosum in adult with mental retardation; they were treated with only free water without desmopressin.
Adult
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Corpus Callosum
;
Deamino Arginine Vasopressin
;
Humans
;
Hypernatremia
;
Hypothalamus, Anterior
;
Intellectual Disability
;
Thirst
;
Water
7.A Case of Incidental Struma Ovarii Confounded with the Metastasis of Papillary Thyroid Cancer.
Young Hee JUNG ; Sung Min JUNG ; Jong Min LEE ; Yi Sun JANG ; In Suk LEE ; Jong Ok KIM ; Hye Soo KIM
Endocrinology and Metabolism 2012;27(3):227-231
A focal radioactive iodine uptake in the pelvis of a patient with differentiated thyroid cancer needs differential diagnosis besides bone metastasis. Struma ovarii is a rare monodermal ovarian teratoma composed predominantly of mature thyroid tissue; 5-10% of these tumors are malignant. As diagnosis and surgery of thyroid cancer have increased recently, incidental cases of struma ovarii, after radioactive iodine treatment, were occasionally reported. Rare cases of ovary metastasis of thyroid cancer were also reported. We report a case of benign struma ovarii incidentally found in a patient with papillary thyroid cancer. The patient showed a sustained high level of thyroglobulin and focal radioactive iodine uptake in the right pelvis, confused with distant metastasis, after total thyroidectomy and radioactive iodine treatment.
Diagnosis, Differential
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Female
;
Humans
;
Iodine
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Neoplasm Metastasis
;
Ovary
;
Pelvis
;
Struma Ovarii
;
Teratoma
;
Thyroglobulin
;
Thyroid Gland
;
Thyroid Neoplasms
;
Thyroidectomy
8.A Case of Actinomycotic Thyroiditis in an Adult with Piriform Sinus Fistula.
Hyun Ju CHOI ; Bo Won KIM ; Min Ji SHIN ; Bo Kwang CHOI ; Ji Hyun KANG ; Yun Kyung JEON ; Sang Soo KIM ; Bo Hyun KIM ; In Ju KIM ; Yong Ki KIM
Endocrinology and Metabolism 2012;27(3):222-226
Acute suppurative thyroiditis is an uncommon infectious thyroid disease affecting mainly children and young adults. The route of infection is frequently a pyriform sinus fistula. The major pathogens responsible for acute bacterial suppurative thyroiditis are the Streptococcus and Staphylococcus species. In contrast, Actinomyces species are a very rare cause of acute suppurative thyroiditis. We experienced a case of a 23-year-old man who has presented general weakness and neck pain. Thyroid ultrasonography showed an ill-defined area of heterogeneous hypoechogenicity in the left lobe of the thyroid gland. Histologic examination by fine needle aspiration demonstrated gram-positive, filamentous-like organisms with branching hyphae and characteristic sulfur granules. Barium esophagogram showed a linear barium-filled track at the left pyriform sinus. We report a case of actinomycotic thyroiditis in a young adult with pyriform sinus fistula along with a brief review of related literature.
Actinomyces
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Actinomycosis
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Adult
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Barium
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Biopsy, Fine-Needle
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Child
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Fistula
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Humans
;
Hyphae
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Neck Pain
;
Pyriform Sinus
;
Staphylococcus
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Streptococcus
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Sulfur
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Thyroid Diseases
;
Thyroid Gland
;
Thyroiditis
;
Thyroiditis, Suppurative
;
Track and Field
;
Young Adult
9.A Case of Ectopic Thyroid Tissue Diagnosed by Fine Needle Aspiration in the Lateral Neck.
Kyung Nam LEE ; Sang Mi KIM ; Jin Hee CHOI ; Kwang Duck RYU ; Bo Won KIM ; Min Ji SHIN ; Bo Hyun KIM ; In Ju KIM
Endocrinology and Metabolism 2012;27(3):217-221
Ectopic thyroid glands generally occur in the midline as a result of abnormal median migration and their presence in lateral to the midline is rare. Embryologically, the thyroid gland is derived from two anlages: a large median endodermal anlage and two lateral anlages. The median anlage produces most of the thyroid parenchyma, whereas the lateral anlage is derived from the fourth pharyngeal pouch and contributes 1-30% of the thyroid weight. In rare cases, failure of the lateral anlage to fuse with the median anlage can result in lateral ectopic thyroid gland. For many years, lateral, aberrant thyroid tissue in adults was a term used almost exclusively for metastatic thyroid carcinoma. However, aberrant, benign ectopic thyroid tissue rarely occurs. We present a 47-year-old man who had incidentally detected mass on the right lateral neck. He was clinically in a euthyroid status and the thyroid function test results were normal as well. Neck ultrasonography revealed a mild diffuse goiter and a 1.22 x 0.65 cm sized ovoid mass like lesion was located in the right level IV of the neck. The result of fine needle aspiration cytology was adenomatous goiter without lymphoid tissue or any malignancy. We rarely report aberrant, benign ectopic thyroid presence as a lateral neck mass.
Adult
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Biopsy, Fine-Needle
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Endoderm
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Goiter
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Humans
;
Lymphoid Tissue
;
Middle Aged
;
Neck
;
Thyroid Dysgenesis
;
Thyroid Function Tests
;
Thyroid Gland
;
Thyroid Neoplasms
10.Lipid Profiles and Prevalence of Dyslipidemia in Korean Adolescents.
Shin Hye KIM ; Byung Chul AHN ; Hyojee JOUNG ; Mi Jung PARK
Endocrinology and Metabolism 2012;27(3):208-216
BACKGROUND: The aim of this study is to investigate the distribution of plasma cholesterol and triglyceride levels as well as the prevalence of dyslipidemia among Korean adolescents. METHODS: We analyzed data for 3,045 adolescents aged 10-18 years (1,622 boys and 1,423 girls) who participated in the Korea National Health and Nutrition Examination Surveys from 2007 to 2010. RESULTS: The mean values of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were 159, 89, 89, and 52 mg/dL, respectively. Plasma cholesterol levels were significantly higher in girls than those in boys (162.1 mg/dL vs. 155.6 mg/dL, P < 0.0001). The 90th percentile values of total cholesterol, triglycerides, and LDL-C were 192, 149, 117 mg/dL for boys, and 195, 147, 119 mg/dL for girls. The 10th percentile value of HDL-C was 38 mg/dL for boys and 40 mg/dL for girls. Triglyceride, LDL-C cholesterol levels increased, whereas plasma HDL-C levels decreased with increasing the body mass index (P < 0.0001) in both genders. Total cholesterol levels significantly increased with increasing the body mass index, especially in boys (P < 0.0001). The prevalence of dyslipidemia was 25.2% for boys and 21.7% for girls; this value significantly increased with overweight (37-40%) and obesity (53-56%). Independent predictors (odds ratio) of dyslipidemia were age (1.49), overweight (2.06), and obesity (5.11) for boys; overweight (1.95) and obesity (3.22) for girls. CONCLUSION: Adolescent dyslipidemia is strongly associated with obesity. Lipid screening for overweight or obese youths should be emphasized. Further, longitudinal studies examining the impact of childhood obesity and dyslipidemia on subsequent cardiovascular diseases are needed.
Adolescent
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Aged
;
Body Mass Index
;
Cardiovascular Diseases
;
Cholesterol
;
Dyslipidemias
;
Humans
;
Korea
;
Lipoproteins
;
Mass Screening
;
Obesity
;
Overweight
;
Plasma
;
Prevalence
;
Triglycerides