1.Increased Serum Cathepsin K in Patients with Coronary Artery Disease.
Xiang LI ; Yuzi LI ; Jiyong JIN ; Dehao JIN ; Lan CUI ; Xiangshan LI ; Yanna REI ; Haiying JIANG ; Guangxian ZHAO ; Guang YANG ; Enbo ZHU ; Yongshan NAN ; Xianwu CHENG
Yonsei Medical Journal 2014;55(4):912-919
PURPOSE: Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD). MATERIALS AND METHODS: Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls. RESULTS: The subjects' serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8+/-25.5 ng/mL vs. 86.9+/-25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1+/-26.9 ng/mL vs. 102.6+/-12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01). CONCLUSION: These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.
Aged
;
Biological Markers/blood
;
C-Reactive Protein/metabolism
;
Cathepsin K/*blood
;
Coronary Artery Disease/*blood/metabolism
;
Female
;
Humans
;
Male
;
Middle Aged
2.Increased Serum Cathepsin K in Patients with Coronary Artery Disease.
Xiang LI ; Yuzi LI ; Jiyong JIN ; Dehao JIN ; Lan CUI ; Xiangshan LI ; Yanna REI ; Haiying JIANG ; Guangxian ZHAO ; Guang YANG ; Enbo ZHU ; Yongshan NAN ; Xianwu CHENG
Yonsei Medical Journal 2014;55(4):912-919
PURPOSE: Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD). MATERIALS AND METHODS: Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls. RESULTS: The subjects' serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8+/-25.5 ng/mL vs. 86.9+/-25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1+/-26.9 ng/mL vs. 102.6+/-12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01). CONCLUSION: These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.
Aged
;
Biological Markers/blood
;
C-Reactive Protein/metabolism
;
Cathepsin K/*blood
;
Coronary Artery Disease/*blood/metabolism
;
Female
;
Humans
;
Male
;
Middle Aged