1.Effect of Low-Dose Enalapril in Patients with Mild to Moderate Hypertension.
Jong Hoa BAE ; Hoy Jong KIM ; Chung Whee CHOUE ; Kwon Sam KIM ; Myung Shick KIM ; Jung Sang SONG
Korean Circulation Journal 1988;18(3):441-446
To evaluate the effect on loe-dose enalapril(ACE inhibitor), we administered a single dose of 10 mg/day enalapril to 22 patients(6 mild hypertension and 16 moderate hypertension) for 12 weeks. The systolic and diastolic blood pressures of patients were declined significantly at 4th week and at 12th week(p<0.005) without significant change of rate and body weight. These data were also analyzed in terms of the percent of patients with marked, moderate and mild responses. Enalapril yielded a 72.7% response rate in marked fall and 22.7% response rate in moderate fall which revealed 95.4% of good response rate. Enalapril was tolerated and showed no significant clinical and biochemical adverse reactions. In conclusion, these results indicate that monotherapy with enalapril 10 mg in a single daily dose was effective in the management of mild to moderate uncomplicated essential hypertension and was well tolerated.
Body Weight
;
Enalapril*
;
Humans
;
Hypertension*
2.Effect of nicardipine nitroprusside and enalapril on the survival of random pattern skin flaps in rats.
Han Yong KIM ; Byung Sam KIM ; Gi Young IM ; Sam Yong LEE ; Bek Hyun CHO
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(6):998-1005
No abstract available.
Animals
;
Enalapril*
;
Nicardipine*
;
Nitroprusside*
;
Rats*
;
Skin*
3.A Randomized, Double-Blind Clinical Trial to Determine the Efficacy of Imidapril vs. Enalapril in Patients with Stage 1 to 2 Essential Hypertension.
Young Jin CHOI ; Dae Won SOHN ; Yong Jin KIM ; Hong Ja LEE ; In Ho CHAE ; Hyo Soo KIM ; Cheol Ho KIM ; Byung Hee OH ; Myoung Mook LEE ; Young Bae PARK ; Yun Shik CHOI ; Young Woo LEE
Korean Circulation Journal 1999;29(11):1234-1239
BACKGROUND: Imidapril is a long-acting angiotensin converting enzyme inhibitor, which has been demons-trated to be effective in reducing blood pressure. The purpose of this study is to compare the antihypertensive efficacy, safety and tolerability of imidapril and enalapril in patients with stage 1 to 2 essential hypertension. METHODS: In this double-blind, double-dummy, randomized, parallel study, the efficacy, safety and tolerability of once-daily imidapril versus once-daily enalapril were evaluated in 84 patients with stage 1 - 2 hypertension during 8 weeks. If antihypertensive response was insufficient after 4 week treatment period, the dosage for both study drugs doubled until the end of study. RESULTS: Data from 84 patients who completed the study were eligible for per-protocol analysis. An adequate antihypertensive effect was observed in 47.6% (20/42) in the imidapril group and in 23.8% (10/42) in enalapril group. There was statistically significant difference between the two treatments in the percentage of patients achieving a "reduced blood pressure". The pulse rate did not changed in both groups. Safety profiles were similar between treatments. CONCLUSION: In patients with mild to moderate hypertension, the imidapril group showed better response with regard to antihypertensive effect. Both imidapril and enalapril were well tolerated with similar safety profiles.
Blood Pressure
;
Enalapril*
;
Heart Rate
;
Humans
;
Hypertension*
;
Peptidyl-Dipeptidase A
4.The Effect of Enalapril on the Peak Rates of Left Ventricular Wall Movement in Patients with Dilated Cardiomyopathy.
Cheol Woo KIM ; Yoo Suk JUNG ; Kwang Je LEE ; Mi Hyang KWAK ; Kyung Man KIM ; Tae Ho KIM ; Chee Jeong KIM ; Wang Seong RYU ; Un Ho RYOO
Korean Journal of Medicine 1997;52(5):617-623
OBJECTIVE: Angiotensin-converting enzyme inhibitors have been shown to improve survival in patients with congestive heart failure. To evaluate the efficacy of enalapril in patients with dilated cardiomyopathy during concurrent treatment with digoxin and diuretics, the peak rates of left ventricular movement were assessed after 6 months of follow-up by digitized echocardiography. METHODS: Using a high quality digitizer, continuous measurement of left ventricular dimension and its rate of change (dD/dt) were obtained throughout the cardiac cycle. Normalized rates of wall movement (dD/dt/D) were used for comparison. RESULTS: 1) Compared with control subjects, patients with dilated cardiomyopathy showed much lower Peak(-) dD/dt and Peak(-) dD/dt/D. 2) Peak(+) dD/dt and Peak(+) dD/dt/D were also depressed in patients. 3) Peak dD/dt improved significantly (p<0.05) in the enalapril group (n=16), but did not change in the conventional treatment group (n=20) after 6 months. Peak dD/dt/D improved approximately (p<0.005) in the enalapril group. 5) There were no deaths in 2 treatment groups during initial 6 months, but 3 patients in the conventional treatment group died suddenly during 1 year of follow-up. CONCLUSION: The present study has shown that left ventrieular Peak dD/dt and Peak dD/dt/D are significantly depressed in patients with dilated cardiomyopathy. Enalapril appears to provide well-tolerated and effective long-term therapy by improving peak rates of left ventricular movement in patients with dilated cardiomyopathy.
Angiotensin-Converting Enzyme Inhibitors
;
Cardiomyopathy, Dilated*
;
Digoxin
;
Diuretics
;
Echocardiography
;
Enalapril*
;
Follow-Up Studies
;
Heart Failure
;
Humans
5.Clinical Observation on Antihypertensive Effects of Enalapril.
Choong Hwan KWAK ; Jin Hong CHUNG ; Hyoung Woo LEE ; Shung Chull CHAE ; Jae Eun JUN ; Wee Hyun PARK
Korean Circulation Journal 1989;19(1):97-103
To observe the antihypertensive effects of the angiotensin-converting enzyme inhibitor, enalapril, a daily average dosage of 20mg was administred to 38 patients with essential hypertension for 4 weeks. Changes in blood pressure and heart rate, and the frequencies of adverse reactions during the drug administration were constantly observed. At the end of the 4th week of administration the mean diastolic blood pressure decreased from 104+/-11.3 to 91+/-7.9mmHg(<0.001), and the mean systolic blood pressure from 165+/-16.8 to 142+/-10.6mmHg(P<0.001), An effective antihypertensive action of enalapril was observed in 31 out of 38 cases(82%), and normalization of diastolic blood pressure below 85mmHg was shown in 27 cases(71%). The most remarkable antihypertensive effects were shown at the end of first week, and the effect increased progressively until the end of 4th week of therapy. There were no significant changes in heart rate during the observation period. Adverse reactions occured in only 7 cases(18%). These reactions included headache, dizziness, fatigue, skin rash and facial flushing in the order of frequency. Almost all of these reaction were mild and transient, disappearing spontanously without discontinuation of the medication. In conclusion, enalapril seems to be a safe and effective primary antihypertensive drug for the treatment of essential hypertension.
Blood Pressure
;
Dizziness
;
Enalapril*
;
Exanthema
;
Fatigue
;
Flushing
;
Headache
;
Heart Rate
;
Humans
;
Hypertension
6.A Case of Aortic Dissection Ocurring in a Hypertensive Patient.
Chong Wook PARK ; Hyun Chul KWAK ; Hae Jin YOO ; Soon Hee PARK ; Dong Jun WON ; Jeong Sik PARK ; Gun Pil CHOI ; Hyo Jin LEE ; Soon Gil KIM
Korean Circulation Journal 1997;27(1):113-119
Primary aldosteronism is present in approximately 1% of unselectd hypertensive patients. Adrenal adenoma is a known as one of the surgically curable form of the hypertension. Hypertension is one of the contributing factors for the development of aortic dissection. Cincurrence of aortic dissection in patient with primary aldosteronism is extemely rare. Only one case wasconfirmed by autopsy and reported in the world literature. We report a case of DeBakey type 3 anortic aneursm in a 49-year old hypertensive female patient with primary aldosteronism due to left adrenal adenoma. She underwent left adrenalectomy uneventfully after stabilization of her blood pressure with maximal medical management including nitroprusside, aldactone, enalapril and inderal.
Adenoma
;
Adrenalectomy
;
Autopsy
;
Blood Pressure
;
Enalapril
;
Female
;
Humans
;
Hyperaldosteronism
;
Hypertension
;
Middle Aged
;
Nitroprusside
;
Propranolol
;
Spironolactone
7.A Clinical Study on the Antihypertensive Effect of Enalapril.
Joo Hyun SON ; Sung Soo JUNG ; Young Chun CHOI ; Jeong Hyun KIM ; Heon Kil LIM ; Bang Hun LEE ; Chung Kyun LEE
Korean Circulation Journal 1988;18(3):431-439
Enalapril, a new angiotensin converting enzyme inhibitor,was administered in 30 hypertensive patients for 12 weeks or longer in order to evaluate the antihypertensive effects and side effects (in some cases combination with hydrochlorthiazide). The doses were from 10mg to 40mg once a day. The results were as follows : 1) Before medication and 2, 4, 6, 8, 10 and 12weeks of medication, the average systolic and diastolic pressure were 176.7+/-16.0/108.6+/-7.6, 146.0+/-12.5/91.7+/-6.9, 138.3+/-16.1/87.3+/-10.6, 140.7+/-13.9/87.3+/-9.6, 137.3+/-13.5/87.7+/-9.1, 137.3+/-14.8/87.0+/-8.5, 138.7+/-15.4/87.3+/-9.1mmHg respectively. After 12 weeks of medication, marked or moderate degree of anti-hypertensive effect was observed in 90% of all cases (p<0.005), and the further significant decease of systolic blood pressure after 4 weeks compared with 2 weeks (p<0.025) was observed. 2) There was no significant change in pulse rate before and after medication. 3) There was no significant change in the laboratory findings such as fasting blood sugar, serum BUN, creatinine, cholesterol, GOT, GPT, blood WBC, hemoglobin, hematocrit, and urine protein before and after treatment. 4) The side effects of enalapril were observed in 2 cases of 30 cases (6.6%), mild dizziness and mild fatigue, which were not required discontinuing the medication or decreasing the dose.
Blood Glucose
;
Blood Pressure
;
Cholesterol
;
Creatinine
;
Dizziness
;
Enalapril*
;
Fasting
;
Fatigue
;
Heart Rate
;
Hematocrit
;
Humans
;
Peptidyl-Dipeptidase A
8.Severe Erythrocytosis after Renal Transplantation: Report of One Case.
Gyu Seong CHOI ; Doo Jin KIM ; Young Seok HAN ; Choon Hyuck KWON ; Sung Joo KIM ; Jae Won JOH
The Journal of the Korean Society for Transplantation 2006;20(1):121-123
Erythrocytosis after kidney transplantation is common complications of Renal Transplantation. It afflicts 5~15% of renal transplant recipients and is associated with an increased incidence of thromboembolic events. It is correlated with use of cyclosporine, sex, posttranaplant renal function and type of antihypertensive medications. Invasive therapies for posttransplant erythrocytosis is serial phlebotomy and native nephrectomy. Usually medical therapy with Renin-Angiotensin inhibitor is preferred to invasive therapies. This drug lowers serum level of erythropoietin and then effectively lowers the hematocrit and hemoglobin level. We report the case of a 31-year-old male who had erythrocytosis after renal transplantation. Its hematocrit level is 60% and hemoglobin is 20.2 g/dL. We treated this patient with serial phlebotomy and Enalapril.
Adult
;
Cyclosporine
;
Enalapril
;
Erythropoietin
;
Hematocrit
;
Humans
;
Incidence
;
Kidney Transplantation*
;
Male
;
Nephrectomy
;
Phlebotomy
;
Polycythemia*
;
Transplantation
9.Steroid and enalapril therapy: possible cause of toxic epidermal necrolysis.
Dong Wook KIM ; Da Eun JUNG ; Ja Wook KOO
Korean Journal of Pediatrics 2006;49(3):332-336
Toxic epidermal necrolysis (TEN) is a rare, acute and life-threatening cutaneous drug reaction. TEN is characterized by the sudden onset of extensive necrosis in the epidermis and frequent mucous membrane involvement. The pathogenesis has not yet been elucidated. In addition, no particular treatment for TEN has been established. We report a case of TEN in a 14-year-old-boy, which might have been caused by steroids with enalapril treatment for membranous nephropathy. He recovered after intravenous immunoglobulin therapy.
Enalapril*
;
Epidermis
;
Glomerulonephritis, Membranous
;
Immunization, Passive
;
Mucous Membrane
;
Necrosis
;
Steroids
;
Stevens-Johnson Syndrome*
10.Ticlopidine Induced Bullous Pemphigoid.
Hye Young LEE ; Jin Ok BAEK ; Jong Rok LEE ; Min KIM ; Soo Chan KIM ; Joo Young ROH
Korean Journal of Dermatology 2009;47(9):1019-1023
Bullous pemphigoid (BP) is an acquired autoimmune disease that's characterized by subepidermal vesicles and bullae. The etiology for BP is mostly idiopathic, but numerous observations have suggested the role of certain drugs in the occurrence of bullous pemphigoid. Drugs such as penicillamine, furosemide, captopril, enalapril, sulfasalazine and ampicilline have been reported to be associated with bullous pemphigoid. We report here on a new case of bullous pemphigoid that was probably induced by ticlopidine (thienopyridine, adenosine diphosphate receptor inhibitor) in a 78 year old female patient.
Adenosine Diphosphate
;
Ampicillin
;
Autoimmune Diseases
;
Blister
;
Captopril
;
Enalapril
;
Female
;
Furosemide
;
Humans
;
Pemphigoid, Bullous
;
Penicillamine
;
Sulfasalazine
;
Ticlopidine