Treatment of "extraordinary injuries" is a major challenge for surgeons major in burn care and plastic surgery, though they are experts in wound treatment and repair. The "extraordinary injuries" is very complicated, and its treatment needs multidisciplinary cooperation. Surgeons not only have to master the relevant knowledge, but also should have the expertise to choose the appropriate treatment targeting the special pathological characteristics of the extraordinary wounds. Therefore, surgeons should learn and aggregate more knowledge regarding extraordinary injuries, strengthen muture communication, and encourage research work.
Burns ; surgery ; Humans ; Patient Care Team ; Reconstructive Surgical Procedures ; methods ; Surgery, Plastic ; Wound Healing

OBJECTIVETo evaluate the clinical efficacy of the goat acellular dermal matrix combined with hyaluronic acid (h-GADM) in the treatment of major burns.

METHODSA retrospective analysis of 5 patients with major burns undergoing combines microskin and h-GADM grafting. All patients were male, aged 33 to 50 years, and mean burn area were 83% ± 11%, which III degree wounds 60% to 90%. After extensive burns patients admitted to hospital in accordance with conventional treatment processes included fluid resuscitation, airway management, wound management, infection control and other treatment. The patients received the surgery after the shock of spending and hemodynamically stable. Summarized the feasibility and operative techniques of the new method, and elaborated on details by a typical case as an example.

RESULTSAll the 5 patients were survival, go through the shock period smoothly, not haven any serious complications as lung infection, wound sepsis, septicemia and kidney failure occurred. A total of nine mircoskin graft operations were undergoing and covered 17 limbs. The average time of the h-GADM desquamtion was (17.7 ± 2.7) days after operation, the hospitalization time was (115 ± 27) days. After (72 ± 6) days, the residual wound was less than 5% total body surface area.

CONCLUSIONThe h-GAMD can be a good alternative to cadaver skin in the treatment of major burns.

Acellular Dermis ; Adult ; Animals ; Burns ; surgery ; Goats ; Humans ; Hyaluronic Acid ; therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Skin ; injuries ; Skin Transplantation ; methods