1.Neoadjuvant treatment in human epidermal growth factor receptor 2-positive breast cancer.
Yinhua LIU ; Shiwei LIU ; Email: CONGZHONGFEIXIANG@163.COM. ; Hong ZHANG ; Ling XU ; Ting LI ; Xuening DUAN
Chinese Journal of Surgery 2015;53(12):901-904
Breast cancer is the most prevalent malignancy among females worldwide. Human epidermal growth factor receptor 2 (HER2)-positive breast cancer represents a subtype with aggressive behavior, poor response to treatment and unfavorable prognosis. Anti-HER2-based neoadjuvant treatment has improved clinical outcomes of patients with HER2-positive disease. Pathological complete response (pCR) after neoadjuvant treatment indicates a favorable prognosis. With the development of HER2-targeted therapy and neoadjuvant treatment, numerous studies focus on the predictive factors of pCR or therapeutic resistance of anti-HER2 therapy. Identification of novel predictive factors in HER2-positive breast cancer, such as tumor-infiltrating lymphocytes, will be helpful for clinical decision.
Breast Neoplasms
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Humans
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Neoadjuvant Therapy
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Prognosis
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Receptor, ErbB-2