OBJECTIVEUsing the incidence data from 1989 to 2008 of liver cancer from population in cancer registration areas in China, the differences and changes of gender, urban and rural areas for liver cancer incidence in different years were studied, and the mean age of incidence was analyzed.

METHODSThe incidence data of liver cancer from National Cancer Registration database were sorted and checked. A total of 181 097 new liver cancer cases were collected, covering 711 843 051 person years from 1989 to 2008.Using Poisson regression model, Stratified by gender and areas, changes of incidence gender ratio, ratio of urban and rural, and mean age were analyzed.

RESULTSAfter adjusting the age, the liver cancer incidence in male was about 3 times higher than that in females (ranging from 2.64-3.54), and the ratio change between male and female for the 20 years did not have statistically significant (P = 0.150). The incidence ratio between urban and rural areas has increased from 0.51 in 1989 to 0.61 in 2008 (P < 0.01). The mean ages of diagnosis for male and female increased from 57.14 years to 60.34 years, 61.69 years to 66.47 years, respectively from 1989 to 2008. The mean age of liver cancer diagnosis has increased in the 20 years (P < 0.01).

CONCLUSIONThe liver cancer incidence between male and female did not change significantly among 20 years. The difference of liver cancer incidence between urban and rural areas has reduced, and the mean age of diagnosis was deferred.

Age of Onset ; Aged ; China ; Female ; Humans ; Incidence ; Liver Neoplasms ; epidemiology ; Male ; Registries ; Rural Population ; Urban Population

OBJECTIVETo analyze the changes of male/female and urban/rural incidences and average age of cancer diagnosis over the period 1989-2008 in China.

METHODSAll cancer incident cases from 1989 to 2008 in registration areas were retrieved from the National Central Cancer Registry database. Data were stratified by sex (male/female) and area (urban/rural) and age group (19 age groups, including 0, 1-4, 5-9, 5-84 by 5, ≥ 85). Poisson regression was used to analyze the differences in incidence rates between males and females, urban and rural areas with 95% confident intervals and P values adjusted by age. The average age of cancer diagnosis was calculated every year. All trends were analyzed by linear regression.

RESULTSThe ratio of male to female cancer incidences was 1.56 in 1989 and 1.35 in 2008. The ratio of urban to rural incidences was 0.89 in 1998 and increased to 0.98 in 2008. The average age of cancer diagnosis was 61.96 years old for men and 60.15 for women in 1989, compared with 64.87 and 61.81 years in 2008, respectively. The disparities in sex and areas have been decreasing in recent 20 years. The cancer patients tend to getting older. These trends were all significant.

CONCLUSIONSThe cancer incidences in male/female populations and different areas have apparent disparities over the 1989-2008 period in China. However, the differences are narrowing and the average age is increasing. In the making of an efficient anti-cancer strategy, we should also take consideration of the differences of cancer burden in different population groups in our country.

China ; epidemiology ; Female ; Humans ; Incidence ; Male ; Neoplasms ; epidemiology ; Registries ; Rural Population ; statistics & numerical data

OBJECTIVETo analysis the incidence and mortality status of thyroid cancer in China, 2010.

METHODSIncidence and mortality data of thyroid cancer were derived from 145 cancer registries in China of 2010.Incidences, mortality, age-specific rates of thyroid cancer in different areas (urban and rural) were calculated. The incident cases and deaths were estimated using age-specific rates and national population data. Chinese census in 2000 and Segi's population were used for age-standardized incidence and mortality rates.

RESULTSThe registration areas covered a total of 158 403 248 population (92 433 739) in urban areas and 65 969 509 in rural areas, which accounted for 12.05% (158 403 248/1 314 873 293) of the total population of the whole country in 2010. The estimates of new cancer incident cases was 54 175 (male 12 962, female 41 213), with the crude incidence rate of 4.12/100 000 (54 175/1 314 873 293). Age-standardized incidence rates by Chinese standard population (ASIRC, 2000) and by world standard population (ASIRW) were 3.62/100 000 and 3.23/100 000, respectively, which accounted for 1.75% (54 175/3 093 039) of all malignant tumors in 2010. Male to female ratio was 1: 3.2, the incidence rate in urban areas was 1.46 times higher than that of rural areas. The estimates number of cancer deaths was 4 504 (male 1 529 cases and female 2 975 cases) in 2010 in China with the crude mortality rate of thyroid cancer 0.34/100 000 (4 504/1 314 873 293). Age-standardized mortality rates by Chinese standard population (ASIRC, 2000) and by world standard population (ASIRW) were 0.27/100 000 and 0.26/100 000, respectively, which accounted for 0.23% (4 504/1 956 662) of all malignant related deaths. The cumulative incidence and mortality rates (0-74 years old) were 0.32% and 0.03%, respectively. According to the data from 145 cancer registries, papillary carcinoma was the main pathology type, which accounted for 86.0% (6 237/7 253) of all malignant tumors.

CONCLUSIONThe incidence and mortality rates of thyroid cancer in urban areas of China were higher than that in rural areas, and females had higher incidence rate of thyroid than males. The reasons related the higher incidence rate of thyroid cancer in urban China should be paid more attention to in the future.

Adolescent ; Aged ; Carcinoma, Papillary ; Child ; China ; epidemiology ; Female ; Humans ; Incidence ; Male ; Neoplasms ; Registries ; Rural Population ; Thyroid Neoplasms ; epidemiology ; mortality ; Urban Population

OBJECTIVEBased on the cancer registry data to analyze the mortality and survival of liver cancer in China.

METHODSLiver cancer data of 2011 were retrieved from the National Cancer Registry Database.Liver cancer deaths were estimated using age-specific rate by areas and gender according to the national population in 2011. Mortality data from 22 cancer registries during 2000-2011 were used to analyze the mortality trend, and data from 17 cancer registries during 2003-2005 were used for survival analysis.

RESULTSThe estimates of liver cancer deaths were about 322 thousand in 2011 with a crude mortality rate of 23.93/10(5).There was an increasing trend of crude mortality rate of liver cancer during 2000-2011 in 22 Chinese cancer registries with an average annual percentage change of 0.7% (95%CI: 0.2%-1.2%), 1.1% in urban and 0.4% in rural areas. After age standardization with Segi's population, the mortality rate was significantly decreased, with an APC of -2.3%, -1.9% in urban and -2.2% in rural populations. The 5-year age standardized relative survival was 10.1% (95%CI: 9.5% to 10.7%), and the 1-, 3- and the 5-year observed survival rates were 27.2%, 12.7%, and 8.9%, respectively.

CONCLUSIONLiver cancer is a major cancer threatening people's lives and health in China, and the liver cancer burden is still high.

China ; epidemiology ; Databases, Factual ; statistics & numerical data ; Humans ; Incidence ; Liver Neoplasms ; mortality ; Registries ; statistics & numerical data ; Rural Population ; statistics & numerical data ; trends ; Survival Analysis ; Survival Rate ; Urban Population

OBJECTIVEThe national population-based cancer registration data were used to analyze the liver cancer incidence and trend in China, in order to provide advise for making further strategy on liver cancer prevention and control.

METHODSLiver cancer data of 2011 were retrieved from the database of the National Cancer Registry. The incident cases of liver cancer were estimated using age-specific rate by urban or rural areas and gender according to the national population in 2011. Liver cancer incidence data from 22 cancer registries were used to analyze the incidence trend during 2000-2011.

RESULTSThe estimates of new cases of liver cancer were about 356 thousand in China in 2011. The incidence rate was 26.39/10(5,) and the age-standardized incidence rates by Chinese standard population and by world population were 19.48/10(5) and 19.10/10(5,) respectively.There was an increasing trend of incidence rate of liver cancer in China during 2000-2011 with an average annual percentage change(AAPC) of 1.0% (95%CI: 0.5%-1.4%), 1.2% (95%CI: 0.7%-1.8%)in urban areas and 1.1% (95%CI: 0.5%-1.8%) in rural areas. After age standardization, the incidence rate was significantly decreased, with an AAPC of -1.8% (95%CI: -2.4% to -1.2%), -1.6% (95%CI: -2.2% to -0.9%) in urban and -1.4% (95%CI: -2.5% to -0.3%) in rural areas.

CONCLUSIONSLiver cancer is a common cancer in China. As changing in people's dietary habits and implementing neonatal HBV vaccination for years, the exposure to risk factors is reducing, and age-standardized incidence rate is decreasing. While cardinal number of population is big and aging population is growing rapidly in the country, trend of incidence rate is increasing, and the burden of liver cancer is still high in China.

China ; epidemiology ; Databases, Factual ; statistics & numerical data ; Health Transition ; Humans ; Incidence ; Liver Neoplasms ; epidemiology ; prevention & control ; Registries ; statistics & numerical data ; Risk Factors ; Rural Population ; statistics & numerical data ; trends ; Urban Population ; statistics & numerical data ; trends