BACKGROUND: Superficial bacterial infection is among the most common reasons for dermatologic consult. Numerous published articles suggest that the dried leaf of malunggay exhibits antibacterial property.
OBJECTIVES: To compare the effectiveness and safety of 15% malunggay ointment with 2% mupirocin ointment in treating localized pyoderma.
METHODS: Sixty-three patients with localized pyoderma (?10% of total body surface area) were enrolled in this randomized, double-blind study to apply either 15% malunggay or 2%  mupirocin ointment twice daily for 14 days. Clinical evaluation using the Global Assessment Score (GAS) for pruritus, pain, erythema, vesiculation, moistness and crusting were conducted at baseline and days 3, 7 and 14 of clinic visit.
RESULTS: Both malunggay and mupirocin groups showed significant decreases in GAS from baseline to days 3, 7 and 14 of treatment (p=0.000, Repeated measures, ANOVA). By days 7 and 14, median GAS of malunggay ointment was higher than mupirocin (1 vs. 0, p<0.05, Mann Whitney U Test). Cure rates were higher in the mupirocin arm comapred to the malunggay arm in Day 3 (53.13% vs. 38.71%), Day 7 (93.75% vs. 70.97%) and Day 14 (96.88% vs. 77.42%). No adverse events were noted after application of malunggay-based ointment at the end of the study period. There were no recurrence two weeks post treatment.
CONCLUSION: Patients in the mupirocin treatment arm had significantly lower global assessment scores and higher cure rates compared to those in the malunggay treatment arm.

Human ; Male ; Female ; Adult ; Child ; Ambulatory Care ; Anti-bacterial Agents ; Bacterial Infections ; Erythema ; Mupirocin ; Ointments ; Pain ; Pruritus ; Pyoderma

Syringocystadenoma papilliferum is a rare benign adnexal skin tumor of apocrine or eccrine differentiation. It usually appears at puberty wherein a third of cases arise within a nevus sebaceous. We report a 14 year-old male with an erythematous fleshy plaque on the scalp of 3 years duration that developed from a pre-existing hairless plaque since birth. Histopathology confirmed the above diagnosis.

Nevus comedonicus is a rare developmental anomaly of the pilosebaceous unit presenting as grouped dilated follicular orifices plugged with keratin. The comedones are usually arranged unilaterally along the lines of Blaschko. As of year 2000, only 200 cases have been reported.

INTRODUCTION

Psoriasis is a chronic, immune-mediated polygenic skin disorder characterized by epidermal hyperplasia. Cardinal histopathological features are as follows: hyperkeratosis, parakeratosis, neutrophils in the stratum corneum and spinous layer, hypogranulosis with suprapapillary thinning, acanthosis, clubbed rete ridges, dilated capillaries, and perivascular lymphocytes. As histopathology may be more definitive compared to clinical manifestations, being able to diagnose psoriasis accurately through histopathology may enable early diagnosis and treatment. This could ideally mean a decrease in its progression, prevention of complications, and improvement of quality of life for psoriatic persons.

OBJECTIVES

To examine, grade, and compare histopathologic f indings of psoriatic lesions with established parameters from previous literature.

METHODS

This is a retrospective descriptive study that will examine, grade, and compare all histopathologic findings of psoriatic lesions of patients who have accessed care at Ospital ng Manila Medical Center from 2010-2015 with established parameters from previous literature.

RESULTS

All 41 cases (100%) showed parakeratosis, followed in decreasing order by 19 cases (46.34%) with Munro's microabscesses, 15 cases (36.59%) with pustules of Koga, 15 cases (36.59%) with hypogranulosis, and 11 cases (26.83%) with spongiosis. Using the visual analogue scale of Moorchung Net al (2013), 28 cases (68.29%) showed mild inflammatory infiltrates, followed in decreasing order by 19 cases (46.34%) with mild epidermal hyperplasia, 12 cases (29.27%) with mild capillary proliferation, and 4 cases (9.77%) with mild suprapapillary thinning.

CONCLUSIONS

Findings of the current study showed histopathologic features of both early and fully developed lesions based on established psoriasis histopathological parameters. Recognized histopathological features were not consistently found in well-developed lesions.

Human ; Psoriasis ; Histopathology ; Pathology