1.The Trends of the Korean Medicare under the IMF Contorl.
Journal of the Korean Medical Association 1998;41(5):470-472
No abstract available.
Medicare*
2.Two Cases of Extramammar Paget's Disease.
Duck Pyo HONG ; Eil Soo LEE ; Dong Chul KIM ; Kye Yong SONG
Korean Journal of Dermatology 1986;24(5):712-716
We have experienced two cases of extramammary Paget's disease. The first case was a 68-year-old male who showed erythematous, crusted, oozing, eczematoid patches on the scroturn, penile root and pubic area, and verrucous plaque on the left pubic area of 5 years' duration. The second case was a 60-year-old male who showed erythematous, oozing, hyperkeratotic plaque and nodular mass on the scrotum of 4 years' duration. In electron microscopic findings of the first case, the Paget's cells was suggested to be formed by pleuripotential germinative cells; well developed microvilli, numerous electron lucent secretory granules, a few electron dense granules, apocrine type secretion and well developed desmosome.
Aged
;
Desmosomes
;
Humans
;
Male
;
Microvilli
;
Middle Aged
;
Paget Disease, Extramammary
;
Scrotum
;
Secretory Vesicles
3.Polymerase Chain Reaction and Heteroduplex Analysis Based Detection of Clonal T Cell Receptor Gamma Gene Rearrangements in Paraffin-embedded Tissues of Cutaneous T Cell Proliferative Diseases.
Un Cheol YEO ; Kyungho PARK ; Young Hyeh KO ; Eil Soo LEE ; Kwang Ho HAN ; Chul Woo KIM ; Kwang Hyun CHO
Annals of Dermatology 2001;13(3):139-147
BACKGROUND: Recently, the molecular pathologic investigation for clonality in lymphomas has been introduced and has gained a role in the diagnosis of lymphomas. In fact, the clonality test using TCRGR phenomenon has been done by Southern blot analysis (SBA) and polymerase chain reaction (PCR) for molecular pathologic diagnosis of T cell lymphomas. However, it is difficult to perform SBA with paraffin embedded specimens or with samples of small skin biopsies. OBJECTIVE: We investigated the efficacy of PCR amplification of TCR gene in paraffin em-bedded cutaneous T cell lymphomas. METHODS: Iii this study, the clonality was assessed by polymerase chain reaction (PCR) analysis of T cell receptor gamma (TCR) gene from the DNA extracts obtained from paraffin em-bedded tissues (PET) of malignant T cells, B cell lymphomas, and benign cutaneous T cell proliferative disorders. Heteroduple-x-analyses were also performed to rule out the false positives. RESULTS: Among the total of 62 cases analyzed, monoclonality was observed in 4 out of 10 mycosis fungoides, 7 out of 9 cutaneous T cell lymphomas excluding mycosis fungoides, 1 out of 3 angiocentric lymphomas, 2 out of 2 lymphomatosis papulosis, 1 out of 7 large plaque parapsoriasis, and 1 out of 2 T cell lymphomas in other organs. No monoclonality was observed in 9 inflammatory cutaneous diseases, 5 small plaque parapsoriasis, 4 cutaneous B cell lymphomas, and 11 B cell lymphomas in lymph nodes. CONCLUSION: The results suggest that the PCR method and heteroduplex analysis used in this study were not only practical but also efficacious for the diagnosis of cutaneous T cell lymphomas using tissues embedded in paraffins.
Biopsy
;
Blotting, Southern
;
Diagnosis
;
DNA
;
Gene Rearrangement*
;
Genes, T-Cell Receptor
;
Heteroduplex Analysis*
;
Lymph Nodes
;
Lymphoma
;
Lymphoma, B-Cell
;
Lymphoma, T-Cell
;
Lymphoma, T-Cell, Cutaneous
;
Mycosis Fungoides
;
Paraffin
;
Parapsoriasis
;
Polymerase Chain Reaction*
;
Receptors, Antigen, T-Cell*
;
Skin
;
T-Lymphocytes
4.Allergic contact dermatitis due to topical medicaments in Korea.
Hong Jig KIM ; Kyeong Joon HYEON ; Hong Eil KUK ; Hai Min CHOI ; Kee Chan MOON ; Choong Rim HAW ; Soo Chan KIM ; Hee Chul EUN ; Chung Won KIM ; Hyung Ok KIM ; Young Pio KIM ; Eil Soo LEE
Korean Journal of Dermatology 1991;29(1):32-40
No abstract available.
Acne Vulgaris
;
Allergens
;
Dermatitis, Allergic Contact*
;
Dermatitis, Contact
;
Hospitals, University
;
Incidence
;
Korea*
;
Mass Screening
;
Merbromin
;
Patch Tests
;
Potassium
;
Povidone
;
Povidone-Iodine
5.Polyarteritis Nodosa in Superior Mesenteric Artery: A Case Report.
Young Lan SEO ; Chul Soon CHOI ; Ho Chul KIM ; Sang Hoon BAE ; Eil Seong LEE ; Eun Sook NAM
Journal of the Korean Radiological Society 1998;38(3):441-444
Polyarteritis nodosa(PAN) is a multisystem disease characterized by necrotizing vasculitis of small andmedium-sized arteries, and in 50% of all cases there is gastrointestinal involvement. We describe a patient withPAN involving the gastrointestinal tract. A small bowel series showed nodular fold thickening, submucosal fillingdefects, shallow ulcerations, segmental luminal narrowing, and decreased peristalsis at the duodenum, jejunum, andileum; superior mesenteric arteriography showed hypervascularity and microaneurysm. Segmental resection of thesmall bowel indicated the presence of PAN.
Angiography
;
Arteries
;
Arteritis
;
Duodenum
;
Gastrointestinal Tract
;
Humans
;
Jejunum
;
Mesenteric Artery, Superior*
;
Peristalsis
;
Phenobarbital
;
Polyarteritis Nodosa*
;
Ulcer
;
Vasculitis
6.The predictability of the Tc-99m pyrophosphate scan and statistical evaluation of the trade-off point.
Eun Young KWACK ; Hyo Heon KIM ; Hyeun Cha CHO ; Chul Soon CHOI ; Eil Seong LEE ; Ik Won KANG ; Jong Sup YOON
Journal of the Korean Radiological Society 1993;29(6):1341-1345
The technetium (Tc)-99m pyrophosphate scans have been used to diagnose acute myocardial infarctions and to confirm the equivocal cases. Many articles have been reported about its diagnostic performance and pitfalls. But there has been no evaluation of its predictability according to the grades of the radioactivity land statistical evaluation of the trade-off point, i.e., grade 2 and the area under the receiver operating characteristic curve. To achieve the goals, we reviewed 252 cases of Tc-99m pyrophosphate scans (acute transmural infarction [n=99], acute subendocardial infarction [n=7], unstable angina[n=16], old myocardial infarction [n=19] others [n=111]). The predictabilities of the scan are 98% in grade 4, 84% in grade 3, 83% in grade 2, 53% in grade 1 and 18% in non-uptake. The usual trade-off point, grade 2 is not statistically significant(Z=1.945, P=0.0259>0.01). The area under the receiver operating characteristic curve(Az) is 0.885. Our study shows that the probable main cause of the false negative cases is the time interval between the onset of symptoms and the test.
Infarction
;
Myocardial Infarction
;
Radioactivity
;
ROC Curve
;
Technetium
7.Cutaneous Adverse Effects Associated with Sorafenib Therapy (Nexavar(R), BAY 43-9006).
Ji Ho PARK ; Song KIM ; Sun Chul CHOI ; Eil Soo LEE ; Jun Mo YANG
Korean Journal of Dermatology 2008;46(1):141-143
Sorafenib (Nexavar(R), BAY 43-9006) is a new oral multi-targeted tyrosine kinase inhibitor developed to delay disease progression in advanced solid organ malignancies and metastatic melanoma. Among the many reported toxicities attributed to sorafenib, dermatologic events, such as skin rash, acral erythema, alopecia and xerosis are the most frequently observed side effects. Recently, we experienced a case of a 41-year-old man who presented with generalized maculopapular erythematous eruptions, and acral erythema after sorafenib treatment for his metastatic hepatocellular carcinoma. Herein, we report the case and discuss the undesirable side effects of sorafenib.
Adult
;
Alopecia
;
Bays
;
Carcinoma, Hepatocellular
;
Disease Progression
;
Erythema
;
Exanthema
;
Humans
;
Melanoma
;
Niacinamide
;
Phenylurea Compounds
;
Protein-Tyrosine Kinases
8.A Clinical observation on Skin Disease of Elderly patients.
Woo Seok KOH ; Ho Chel CHOI ; Byung Su KIM ; Si Won LEE ; Seung Chul LEE ; Jae Hak YOO ; Kae Jeung KIM ; Seung Young JUNG ; Un Cheol YEO ; Eil Soo LEE ; Young Gull KIM ; Hee Chul EUN
Korean Journal of Dermatology 1999;37(5):614-619
BACKGROUND: It is a trend that the average life span is prolonged in proportion to the advance of socio-economy and medical science. Consequently, the number of elderly patients with skin diseases is increasing. OBJECTIVE: This study was performed to see the change of patterns of skin diseases in elderly patients. METHODS: One thousand four hundred and twenty elderly patients, over the age of 65, who visited the departments of dermatology and in five hospitals, from January 1, 1997 to December 31, 1997 were selected. We surveyed the frequeney of skin disease by types and the distributions by month, season and age.
Aged*
;
Dermatology
;
Epidemiologic Studies
;
Humans
;
Seasons
;
Skin Diseases*
;
Skin*
9.An Epiderniological Study of Contact Dermatitis: I . Multicenter Trials.
Hee Chul EUN ; Chang Jo KOH ; Hong Il KOOK ; Duck Hyun KIM ; Chung Won KIM ; Hong Jig KIM ; Ki Bum MYUNG ; Kee Chan MOON ; Eil Soo LEE ; Soo Duk LIM ; Choong Rim HAW
Korean Journal of Dermatology 1986;24(3):335-339
The present work is the first joint epidermiological study of contact dermatitis carried out by the Korean Contact Dermatitis Research Group which was organized in 15i8p. For the past 2 years total 937 patients with contact dermatitie and suspected contact dermatitis have been routinely patch tested with Hollister-Stier standard battery (28 different antigens) by using Finn Chamber at 10 different General Hospitals which were located around Seoul area. The MOHL index was quite different from the western data, which was characterized with less male, rare leg ulcer and less occupational cases. However, housewife hand eczema cases were more common. The most common senaitiaers were ammoniated mercury, nickel sulfate, potassium dichromate, cinnamic alcohol, neomycin sulfate, paraphenylendiamine, balsam of Peru and thimerosal in order of frequency.
Dermatitis, Contact*
;
Eczema
;
Epidemiology
;
Hand
;
Hospitals, General
;
Humans
;
Joints
;
Leg Ulcer
;
Male
;
Neomycin
;
Nickel
;
Patch Tests
;
Peru
;
Potassium Dichromate
;
Seoul
;
Thimerosal
10.A Case of Morpheaform Sarcoidosis.
Sun Chul CHOI ; Hyun Je KIM ; Cho Rok KIM ; Ji Yeon BYUN ; Dong Youn LEE ; Joo Heung LEE ; Eil Soo LEE ; Jun Mo YANG
Annals of Dermatology 2010;22(3):316-318
Sarcoidosis is an idiopathic multisystem disease with various cutaneous presentations, and it is characterized by the presence of non-caseating granulomas in the affected organs. The specific manifestations are papules, plaques, nodules, ulcers and scar. We report here on a variant of sarcoidosis on a 71-year-old woman who showed an indurated plaque on the forearm. Her lesion's appearance was clinically similar to that of a morphea and the appearance of the lesion was unlike the commonly observed manifestations of sarcoidosis.
Aged
;
Cicatrix
;
Female
;
Forearm
;
Granuloma
;
Humans
;
Sarcoidosis
;
Scleroderma, Localized
;
Ulcer