1.Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens.
Warren CHANDA ; Thomson P JOSEPH ; Xue-Fang GUO ; Wen-Dong WANG ; Min LIU ; Miza S VUAI ; Arshad A PADHIAR ; Min-Tao ZHONG
Journal of Zhejiang University. Science. B 2018;19(4):253-262
Microorganisms provide both beneficial and harmful effects to human beings. Beneficial effects come from the symbiotic relationship that exists between humans and microbiota, but then several human illnesses have turned some friendly microbes into opportunistic pathogens, causing several microbial-related diseases. Various efforts have been made to create and utilize antimicrobial agents in the treatment and prevention of these infections, but such efforts have been hampered by the emergence of antimicrobial resistance. Despite extensive studies on drug discovery to alleviate this problem, issues with the toxicity and tolerance of certain compounds and continuous microbial evolution have forced researchers to focus on screening various phytochemical dietary compounds for antimicrobial activity. Linolenic acid and its derivatives (eicosapentaenoic acid and docosahexaenoic acid) are omega-3 fatty acids that have been studied due to their role in human health, being important for the brain, the eye, the cardiovascular system, and general human growth. However, their utilization as antimicrobial agents has not been widely appreciated, perhaps due to a lack of understanding of antimicrobial mechanisms, toxicity, and route of administration. Therefore, this review focuses on the efficacy, mechanism, and toxicity of omega-3 fatty acids as alternative therapeutic agents for treating and preventing diseases associated with pathogenic microorganisms.
Animals
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Animals, Genetically Modified
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Anti-Infective Agents/chemistry*
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Antioxidants/chemistry*
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Bacterial Infections/microbiology*
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Cell Membrane/drug effects*
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Clinical Trials as Topic
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Docosahexaenoic Acids/chemistry*
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Drug Resistance, Bacterial
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Eicosapentaenoic Acid/chemistry*
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Fatty Acids, Omega-3/chemistry*
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Fishes
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Humans
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Lipids/chemistry*
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Mice
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Microbiota
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Rats
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alpha-Linolenic Acid/chemistry*
2.The influence of maternal ethnic group and diet on breast milk fatty acid composition.
Lin Lin SU ; Thamarai Chelvi S K ; Su Lin LIM ; Yuming CHEN ; Elizabeth A T TAN ; Namratha Narayan PAI ; Yin Han GONG ; Janie FOO ; Mary RAUFF ; Yap Seng CHONG
Annals of the Academy of Medicine, Singapore 2010;39(9):675-675
INTRODUCTIONBreast milk fatty acids play a major role in infant development. However, no data have compared the breast milk composition of different ethnic groups living in the same environment. We aimed to (i) investigate breast milk fatty acid composition of three ethnic groups in Singapore and (ii) determine dietary fatty acid patterns in these groups and any association with breast milk fatty acid composition.
MATERIALS AND METHODSThis was a prospective study conducted at a tertiary hospital in Singapore. Healthy pregnant women with the intention to breastfeed were recruited. Diet profile was studied using a standard validated 3-day food diary. Breast milk was collected from mothers at 1 to 2 weeks and 6 to 8 weeks postnatally. Agilent gas chromatograph (6870N) equipped with a mass spectrometer (5975) and an automatic liquid sampler (ALS) system with a split mode was used for analysis.
RESULTSSeventy-two breast milk samples were obtained from 52 subjects. Analysis showed that breast milk ETA (Eicosatetraenoic acid) and ETA:EA (Eicosatrienoic acid) ratio were significantly different among the races (P = 0.031 and P = 0.020), with ETA being the highest among Indians and the lowest among Malays. Docosahexaenoic acid was significantly higher among Chinese compared to Indians and Malays. No difference was demonstrated in n3 and n6 levels in the food diet analysis among the 3 ethnic groups.
CONCLUSIONSDifferences exist in breast milk fatty acid composition in different ethnic groups in the same region, although no difference was demonstrated in the diet analysis. Factors other than maternal diet may play a role in breast milk fatty acid composition.
Arachidonic Acids ; metabolism ; Breast Feeding ; ethnology ; Diet ; Diet Records ; Docosahexaenoic Acids ; metabolism ; Eicosapentaenoic Acid ; metabolism ; Ethnic Groups ; Fatty Acids ; metabolism ; Female ; Humans ; India ; ethnology ; Malaysia ; ethnology ; Maternal Welfare ; Milk, Human ; chemistry ; Nutritional Status ; Pregnancy ; Prenatal Nutritional Physiological Phenomena ; Prospective Studies ; Singapore ; Statistics, Nonparametric