1.Keeping dimple's smile: The family that went far beyond expectations.
Gonzales Erica Tricia S ; Florendo Charles Edward G ; Asuncion Ellaine Anne V ; Garcia Garret Lee
The Filipino Family Physician 2014;52(1):30-52
Human
;
Female
;
Aged 80 and over
;
quality of life
;
adenocarcinoma
;
neoplasms
;
Colon
2.Acute kidney injury aggravated by treatment initiation with apixaban: Another twist of anticoagulant-related nephropathy.
Sergey V BRODSKY ; Nilesh S MHASKAR ; Sampath THIRUVEEDI ; Rajnish DHINGRA ; Sharon C. REUBEN ; Edward CALOMENI ; Iouri IVANOV ; Anjali SATOSKAR ; Jessica HEMMINGER ; Gyongyi NADASDY ; Lee HEBERT ; Brad ROVIN ; Tibor NADASDY
Kidney Research and Clinical Practice 2017;36(4):387-392
Anticoagulant-related nephropathy (ARN) was initially described in patients on warfarin (as warfarin-related nephropathy) and recently in those using dabigatran. Herein, we report clinical history and kidney biopsy findings in a patient on apixaban (Eliquis). Initiation of treatment with apixaban resulted in aggravation of preexisting mild acute kidney injury (AKI). A few days after apixaban therapy, the patient became oligoanuric, and kidney biopsy showed severe acute tubular necrosis with numerous occlusive red blood cell casts. Only one out of 68 glomeruli with open capillary loops had small segmental cellular crescent. Therefore, there was major discrepancy between the degree of glomerular injury and the glomerular hematuria. Considering that the onset of this AKI was associated with apixaban treatment initiation, we propose that this patient had ARN associated with factor Xa inhibitor (apixaban), which has not previously been described. Monitoring of kidney function is recommended after initiation of anticoagulant therapy.
Acute Kidney Injury*
;
Biopsy
;
Capillaries
;
Dabigatran
;
Erythrocytes
;
Factor Xa
;
Hematuria
;
Humans
;
Kidney
;
Necrosis
;
Warfarin
3.Surgical prevention of terminal neuroma and phantom limb pain: a literature review
Ronald N. BOGDASARIAN ; Steven B. CAI ; Bao Ngoc N. TRAN ; Ashley IGNATIUK ; Edward S. LEE
Archives of Plastic Surgery 2021;48(3):310-322
The incidence of extremity amputation is estimated at about 200,000 cases annually. Over 25% of patients suffer from terminal neuroma or phantom limb pain (TNPLP), resulting in pain, inability to wear a prosthetic device, and lost work. Once TNPLP develops, there is no definitive cure. Therefore, there has been an emerging focus on TNPLP prevention. We examined the current literature on TNPLP prevention in patients undergoing extremity amputation. A literature review was performed using Ovid Medline, Cochrane Collaboration Library, and Google Scholar to identify all original studies that addressed surgical prophylaxis against TNPLP. The search was conducted using both Medical Subject Headings and free-text using the terms “phantom limb pain,” “amputation neuroma,” and “surgical prevention of amputation neuroma.” Fifteen studies met the inclusion criteria, including six prospective trials, two comprehensive literature reviews, four retrospective chart reviews, and three case series/technique reviews. Five techniques were identified, and each was incorporated into a targetbased classification system. A small but growing body of literature exists regarding the surgical prevention of TNPLP. Targeted muscle reinnervation (TMR), a form of physiologic target reassignment, has the greatest momentum in the academic surgical community, with multiple recent prospective studies demonstrating superior prevention of TNPLP. Neurorrhaphy and transposition with implantation are supported by less robust evidence, but merit future study as alternatives to TMR.
4.Surgical prevention of terminal neuroma and phantom limb pain: a literature review
Ronald N. BOGDASARIAN ; Steven B. CAI ; Bao Ngoc N. TRAN ; Ashley IGNATIUK ; Edward S. LEE
Archives of Plastic Surgery 2021;48(3):310-322
The incidence of extremity amputation is estimated at about 200,000 cases annually. Over 25% of patients suffer from terminal neuroma or phantom limb pain (TNPLP), resulting in pain, inability to wear a prosthetic device, and lost work. Once TNPLP develops, there is no definitive cure. Therefore, there has been an emerging focus on TNPLP prevention. We examined the current literature on TNPLP prevention in patients undergoing extremity amputation. A literature review was performed using Ovid Medline, Cochrane Collaboration Library, and Google Scholar to identify all original studies that addressed surgical prophylaxis against TNPLP. The search was conducted using both Medical Subject Headings and free-text using the terms “phantom limb pain,” “amputation neuroma,” and “surgical prevention of amputation neuroma.” Fifteen studies met the inclusion criteria, including six prospective trials, two comprehensive literature reviews, four retrospective chart reviews, and three case series/technique reviews. Five techniques were identified, and each was incorporated into a targetbased classification system. A small but growing body of literature exists regarding the surgical prevention of TNPLP. Targeted muscle reinnervation (TMR), a form of physiologic target reassignment, has the greatest momentum in the academic surgical community, with multiple recent prospective studies demonstrating superior prevention of TNPLP. Neurorrhaphy and transposition with implantation are supported by less robust evidence, but merit future study as alternatives to TMR.
5.Association between High Diffusion-Weighted Imaging-Derived Functional Tumor Burden of Peritoneal Carcinomatosis and Overall Survival in Patients with Advanced Ovarian Carcinoma
He AN ; Jose AU PERUCHO ; Keith WH CHIU ; Edward S HUI ; Mandy MY CHU ; Siew Fei NGU ; Hextan YS NGAN ; Elaine YP LEE
Korean Journal of Radiology 2022;23(5):539-547
Objective:
To investigate the association between functional tumor burden of peritoneal carcinomatosis (PC) derived from diffusion-weighted imaging (DWI) and overall survival in patients with advanced ovarian carcinoma (OC).
Materials and Methods:
This prospective study was approved by the local research ethics committee, and informed consent was obtained. Fifty patients (mean age ± standard deviation, 57 ± 12 years) with stage III–IV OC scheduled for primary or interval debulking surgery (IDS) were recruited between June 2016 and December 2021. DWI (b values: 0, 400, and 800 s/mm2 ) was acquired with a 16-channel phased-array torso coil. The functional PC burden on DWI was derived based on K-means clustering to discard fat, air, and normal tissue. A score similar to the surgical peritoneal cancer index was assigned to each abdominopelvic region, with additional scores assigned to the involvement of critical sites, denoted as the functional peritoneal cancer index (fPCI). The apparent diffusion coefficient (ADC) of the largest lesion was calculated. Patients were dichotomized by immediate surgical outcome into high- and low-risk groups (with and without residual disease, respectively) with subsequent survival analysis using the Kaplan-Meier curve and log-rank test. Multivariable Cox proportional hazards regression was used to evaluate the association between DWI-derived results and overall survival.
Results:
Fifteen (30.0%) patients underwent primary debulking surgery, and 35 (70.0%) patients received neoadjuvant chemotherapy followed by IDS. Complete tumor debulking was achieved in 32 patients. Patients with residual disease after debulking surgery had reduced overall survival (p = 0.043). The fPCI/ADC was negatively associated with overall survival when accounted for clinicopathological information with a hazard ratio of 1.254 for high fPCI/ADC (95% confidence interval, 1.007–1.560; p = 0.043).
Conclusion
A high DWI-derived functional tumor burden was associated with decreased overall survival in patients with advanced OC.
6.Screening for somatisation in an Asian children's hospital emergency setting.
Siok Hoon ANG ; Juliet S K TAN ; Jiahui LEE ; Vicknesan J MARIMUTTU ; Xin Yi LIM ; Lois L E TEO ; Shannon N EDWARD ; Mavis TEO ; Joyce S T LIM ; Sashikumar GANAPATHY ; Angelina ANG
Annals of the Academy of Medicine, Singapore 2022;51(8):507-509
7.ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head
Quanjun CUI ; Woo-Lam JO ; Kyung-Hoi KOO ; Edward Y. CHENG ; Wolf DRESCHER ; Stuart B. GOODMAN ; Yong-Chan HA ; Phillippe HERNIGOU ; Lynne C. JONES ; Shin-Yoon KIM ; Kyu Sang LEE ; Mel S. LEE ; Yun Jong LEE ; Michael A. MONT ; Nobuhiko SUGANO ; John TALIAFERRO ; Takuaki YAMAMOTO ; Dewei ZHAO
Journal of Korean Medical Science 2021;36(10):e65-
Osteonecrosis of the femoral head (ONFH) is a devastating disease frequently leading to femoral head collapse and hip arthritis. Specifically, non-traumatic ONFH primarily affects young and middle-aged adults. Although compromised local circulation of the femoral head seems to be pathognomonic for the disease, the pathogenesis is perplexing and continues to be an area of scrutiny and research. Comprehension of the pathogenesis is of crucial importance for developing and guiding treatments for the disease. Therefore, we provide an up-to-date consensus on the pathogenesis of non-traumatic ONFH.
8.ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head
Quanjun CUI ; Woo-Lam JO ; Kyung-Hoi KOO ; Edward Y. CHENG ; Wolf DRESCHER ; Stuart B. GOODMAN ; Yong-Chan HA ; Phillippe HERNIGOU ; Lynne C. JONES ; Shin-Yoon KIM ; Kyu Sang LEE ; Mel S. LEE ; Yun Jong LEE ; Michael A. MONT ; Nobuhiko SUGANO ; John TALIAFERRO ; Takuaki YAMAMOTO ; Dewei ZHAO
Journal of Korean Medical Science 2021;36(10):e65-
Osteonecrosis of the femoral head (ONFH) is a devastating disease frequently leading to femoral head collapse and hip arthritis. Specifically, non-traumatic ONFH primarily affects young and middle-aged adults. Although compromised local circulation of the femoral head seems to be pathognomonic for the disease, the pathogenesis is perplexing and continues to be an area of scrutiny and research. Comprehension of the pathogenesis is of crucial importance for developing and guiding treatments for the disease. Therefore, we provide an up-to-date consensus on the pathogenesis of non-traumatic ONFH.
9.Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment
Jeremy T. HINES ; Woo-Lam JO ; Quanjun CUI ; Michael A. MONT ; Kyung-Hoi KOO ; Edward Y. CHENG ; Stuart B. GOODMAN ; Yong-Chan HA ; Phillippe HERNIGOU ; Lynne C. JONES ; Shin-Yoon KIM ; Takashi SAKAI ; Nobuhiko SUGANO ; Takuaki YAMAMOTO ; Mel S. LEE ; Dewei ZHAO ; Wolf DRESCHER ; Tae-Young KIM ; Young-Kyun LEE ; Byung-Ho YOON ; Seung-Hoon BAEK ; Wataru ANDO ; Hong-Seok KIM ; Jung-Wee PARK
Journal of Korean Medical Science 2021;36(24):e177-
Non-traumatic osteonecrosis of the femoral head (ONFH) usually affects adults younger than 50 years and frequently leads to femoral head collapse and subsequent arthritis of the hip.It is becoming more prevalent along with increasing use of corticosteroids for the adjuvant therapy of leukemia and other myelogenous diseases as well as management of organ transplantation. This review updated knowledge on the pathogenesis, classification criteria, staging system, and treatment of ONFH.
10.Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment
Jeremy T. HINES ; Woo-Lam JO ; Quanjun CUI ; Michael A. MONT ; Kyung-Hoi KOO ; Edward Y. CHENG ; Stuart B. GOODMAN ; Yong-Chan HA ; Phillippe HERNIGOU ; Lynne C. JONES ; Shin-Yoon KIM ; Takashi SAKAI ; Nobuhiko SUGANO ; Takuaki YAMAMOTO ; Mel S. LEE ; Dewei ZHAO ; Wolf DRESCHER ; Tae-Young KIM ; Young-Kyun LEE ; Byung-Ho YOON ; Seung-Hoon BAEK ; Wataru ANDO ; Hong-Seok KIM ; Jung-Wee PARK
Journal of Korean Medical Science 2021;36(24):e177-
Non-traumatic osteonecrosis of the femoral head (ONFH) usually affects adults younger than 50 years and frequently leads to femoral head collapse and subsequent arthritis of the hip.It is becoming more prevalent along with increasing use of corticosteroids for the adjuvant therapy of leukemia and other myelogenous diseases as well as management of organ transplantation. This review updated knowledge on the pathogenesis, classification criteria, staging system, and treatment of ONFH.