4.Gynecologic cancer in Brazil and the law of sixty days.
Eduardo PAULINO ; Andréia Cristina DE MELO ; Angélica NOGUEIRA-RODRIGUES ; Luiz Claudio Santos THULER
Journal of Gynecologic Oncology 2018;29(3):e44-
No abstract available.
Brazil*
;
Jurisprudence*
5.Assessing 18F‑FDG PET/CT Uptake and its Correlation with Molecular Biomarkers in Penile Cancer
André SALAZAR ; Eduardo Paulino JÚNIOR ; Diego F. SÁNCHEZ ; Aízis Tatiane Santos GONÇALVES ; Renata Toscano SIMÕES ; Raul SILVA‑FILHO ; João V. S. RAIMUNDO ; Yuri V. C. SOARES ; Matheus L. MARINHO ; Antonio L. CUBILLA ; Marcelo MAMEDE
Nuclear Medicine and Molecular Imaging 2025;59(2):135-146
Background:
Penile Cancer is a rare and aggressive disease. Related to complex metabolic processes.
Objective:
This study investigates the effectiveness of 18F-FDG PET/CT as a noninvasive method in evaluating penile cancer patients, focusing on the correlation between tissue expression of key tumor markers involved in glucose metabolism and proliferation, and the uptake of 18F-FDG.
Methods:
Fifty-one patients were selected and underwent 18F-FDG PET/CT-based staging. Semiquantitative analysis wasperformed using the maximum standardized uptake value (SUVmax ) and volumetric SUV (SUV2SD ). Tissue expressionanalysis of GLUT-1, hexokinase-II, Ki67, p16, and p53 was performed by tissue microarray. PCR evaluated HPV DNA.
Results:
Warty SCC showed the highest SUV value and significant differences in SUVmax (p=0.015). Higher SUVmax and SUV2SD values were observed in grade 3 tumors. In typical invasive SCC, grade 3, HPV+, p16-negative, p53-negative,GLUT-1 i-3, and HK-II i-3 tumors showed a higher mean SUV. The Ki-67 value significantly differed for grade 3 tumors (p=0.001) and HK-II i-1 tumors (p=0.036). Ki-67 positivity was also higher in HPV-, p16 i-2, p53 i-3, and GLUT-1 i-3 tumors; none of the differences were statistically significant.
Conclusions
The study highlights correlations between the uptake of 18F-FDG and the expression of markers associated with glycolytic metabolism in penile cancer. It suggests a potential trend where increased expression of glucose transport markers is linked to higher histological grades and Ki-67 expression. There were no significant differences regarding HPV positivity, demonstrating the complexity of penile cancer molecular biology and need more studies with a higher number of patients.
6.Assessing 18F‑FDG PET/CT Uptake and its Correlation with Molecular Biomarkers in Penile Cancer
André SALAZAR ; Eduardo Paulino JÚNIOR ; Diego F. SÁNCHEZ ; Aízis Tatiane Santos GONÇALVES ; Renata Toscano SIMÕES ; Raul SILVA‑FILHO ; João V. S. RAIMUNDO ; Yuri V. C. SOARES ; Matheus L. MARINHO ; Antonio L. CUBILLA ; Marcelo MAMEDE
Nuclear Medicine and Molecular Imaging 2025;59(2):135-146
Background:
Penile Cancer is a rare and aggressive disease. Related to complex metabolic processes.
Objective:
This study investigates the effectiveness of 18F-FDG PET/CT as a noninvasive method in evaluating penile cancer patients, focusing on the correlation between tissue expression of key tumor markers involved in glucose metabolism and proliferation, and the uptake of 18F-FDG.
Methods:
Fifty-one patients were selected and underwent 18F-FDG PET/CT-based staging. Semiquantitative analysis wasperformed using the maximum standardized uptake value (SUVmax ) and volumetric SUV (SUV2SD ). Tissue expressionanalysis of GLUT-1, hexokinase-II, Ki67, p16, and p53 was performed by tissue microarray. PCR evaluated HPV DNA.
Results:
Warty SCC showed the highest SUV value and significant differences in SUVmax (p=0.015). Higher SUVmax and SUV2SD values were observed in grade 3 tumors. In typical invasive SCC, grade 3, HPV+, p16-negative, p53-negative,GLUT-1 i-3, and HK-II i-3 tumors showed a higher mean SUV. The Ki-67 value significantly differed for grade 3 tumors (p=0.001) and HK-II i-1 tumors (p=0.036). Ki-67 positivity was also higher in HPV-, p16 i-2, p53 i-3, and GLUT-1 i-3 tumors; none of the differences were statistically significant.
Conclusions
The study highlights correlations between the uptake of 18F-FDG and the expression of markers associated with glycolytic metabolism in penile cancer. It suggests a potential trend where increased expression of glucose transport markers is linked to higher histological grades and Ki-67 expression. There were no significant differences regarding HPV positivity, demonstrating the complexity of penile cancer molecular biology and need more studies with a higher number of patients.
7.Assessing 18F‑FDG PET/CT Uptake and its Correlation with Molecular Biomarkers in Penile Cancer
André SALAZAR ; Eduardo Paulino JÚNIOR ; Diego F. SÁNCHEZ ; Aízis Tatiane Santos GONÇALVES ; Renata Toscano SIMÕES ; Raul SILVA‑FILHO ; João V. S. RAIMUNDO ; Yuri V. C. SOARES ; Matheus L. MARINHO ; Antonio L. CUBILLA ; Marcelo MAMEDE
Nuclear Medicine and Molecular Imaging 2025;59(2):135-146
Background:
Penile Cancer is a rare and aggressive disease. Related to complex metabolic processes.
Objective:
This study investigates the effectiveness of 18F-FDG PET/CT as a noninvasive method in evaluating penile cancer patients, focusing on the correlation between tissue expression of key tumor markers involved in glucose metabolism and proliferation, and the uptake of 18F-FDG.
Methods:
Fifty-one patients were selected and underwent 18F-FDG PET/CT-based staging. Semiquantitative analysis wasperformed using the maximum standardized uptake value (SUVmax ) and volumetric SUV (SUV2SD ). Tissue expressionanalysis of GLUT-1, hexokinase-II, Ki67, p16, and p53 was performed by tissue microarray. PCR evaluated HPV DNA.
Results:
Warty SCC showed the highest SUV value and significant differences in SUVmax (p=0.015). Higher SUVmax and SUV2SD values were observed in grade 3 tumors. In typical invasive SCC, grade 3, HPV+, p16-negative, p53-negative,GLUT-1 i-3, and HK-II i-3 tumors showed a higher mean SUV. The Ki-67 value significantly differed for grade 3 tumors (p=0.001) and HK-II i-1 tumors (p=0.036). Ki-67 positivity was also higher in HPV-, p16 i-2, p53 i-3, and GLUT-1 i-3 tumors; none of the differences were statistically significant.
Conclusions
The study highlights correlations between the uptake of 18F-FDG and the expression of markers associated with glycolytic metabolism in penile cancer. It suggests a potential trend where increased expression of glucose transport markers is linked to higher histological grades and Ki-67 expression. There were no significant differences regarding HPV positivity, demonstrating the complexity of penile cancer molecular biology and need more studies with a higher number of patients.
8.Assessing 18F‑FDG PET/CT Uptake and its Correlation with Molecular Biomarkers in Penile Cancer
André SALAZAR ; Eduardo Paulino JÚNIOR ; Diego F. SÁNCHEZ ; Aízis Tatiane Santos GONÇALVES ; Renata Toscano SIMÕES ; Raul SILVA‑FILHO ; João V. S. RAIMUNDO ; Yuri V. C. SOARES ; Matheus L. MARINHO ; Antonio L. CUBILLA ; Marcelo MAMEDE
Nuclear Medicine and Molecular Imaging 2025;59(2):135-146
Background:
Penile Cancer is a rare and aggressive disease. Related to complex metabolic processes.
Objective:
This study investigates the effectiveness of 18F-FDG PET/CT as a noninvasive method in evaluating penile cancer patients, focusing on the correlation between tissue expression of key tumor markers involved in glucose metabolism and proliferation, and the uptake of 18F-FDG.
Methods:
Fifty-one patients were selected and underwent 18F-FDG PET/CT-based staging. Semiquantitative analysis wasperformed using the maximum standardized uptake value (SUVmax ) and volumetric SUV (SUV2SD ). Tissue expressionanalysis of GLUT-1, hexokinase-II, Ki67, p16, and p53 was performed by tissue microarray. PCR evaluated HPV DNA.
Results:
Warty SCC showed the highest SUV value and significant differences in SUVmax (p=0.015). Higher SUVmax and SUV2SD values were observed in grade 3 tumors. In typical invasive SCC, grade 3, HPV+, p16-negative, p53-negative,GLUT-1 i-3, and HK-II i-3 tumors showed a higher mean SUV. The Ki-67 value significantly differed for grade 3 tumors (p=0.001) and HK-II i-1 tumors (p=0.036). Ki-67 positivity was also higher in HPV-, p16 i-2, p53 i-3, and GLUT-1 i-3 tumors; none of the differences were statistically significant.
Conclusions
The study highlights correlations between the uptake of 18F-FDG and the expression of markers associated with glycolytic metabolism in penile cancer. It suggests a potential trend where increased expression of glucose transport markers is linked to higher histological grades and Ki-67 expression. There were no significant differences regarding HPV positivity, demonstrating the complexity of penile cancer molecular biology and need more studies with a higher number of patients.
9.Assessing 18F‑FDG PET/CT Uptake and its Correlation with Molecular Biomarkers in Penile Cancer
André SALAZAR ; Eduardo Paulino JÚNIOR ; Diego F. SÁNCHEZ ; Aízis Tatiane Santos GONÇALVES ; Renata Toscano SIMÕES ; Raul SILVA‑FILHO ; João V. S. RAIMUNDO ; Yuri V. C. SOARES ; Matheus L. MARINHO ; Antonio L. CUBILLA ; Marcelo MAMEDE
Nuclear Medicine and Molecular Imaging 2025;59(2):135-146
Background:
Penile Cancer is a rare and aggressive disease. Related to complex metabolic processes.
Objective:
This study investigates the effectiveness of 18F-FDG PET/CT as a noninvasive method in evaluating penile cancer patients, focusing on the correlation between tissue expression of key tumor markers involved in glucose metabolism and proliferation, and the uptake of 18F-FDG.
Methods:
Fifty-one patients were selected and underwent 18F-FDG PET/CT-based staging. Semiquantitative analysis wasperformed using the maximum standardized uptake value (SUVmax ) and volumetric SUV (SUV2SD ). Tissue expressionanalysis of GLUT-1, hexokinase-II, Ki67, p16, and p53 was performed by tissue microarray. PCR evaluated HPV DNA.
Results:
Warty SCC showed the highest SUV value and significant differences in SUVmax (p=0.015). Higher SUVmax and SUV2SD values were observed in grade 3 tumors. In typical invasive SCC, grade 3, HPV+, p16-negative, p53-negative,GLUT-1 i-3, and HK-II i-3 tumors showed a higher mean SUV. The Ki-67 value significantly differed for grade 3 tumors (p=0.001) and HK-II i-1 tumors (p=0.036). Ki-67 positivity was also higher in HPV-, p16 i-2, p53 i-3, and GLUT-1 i-3 tumors; none of the differences were statistically significant.
Conclusions
The study highlights correlations between the uptake of 18F-FDG and the expression of markers associated with glycolytic metabolism in penile cancer. It suggests a potential trend where increased expression of glucose transport markers is linked to higher histological grades and Ki-67 expression. There were no significant differences regarding HPV positivity, demonstrating the complexity of penile cancer molecular biology and need more studies with a higher number of patients.