Objective To explore the designing and delivery strategies of nursing interventions, in order to improve the design level and delivery effect. Methods We expounded the idea through litera-ture review and the author′s practical experience in research work. Results The adoption and design of nursing intervention were discussed from literature review, theoretical framework, meta- analysis, and expert opinions. Strategies were recommended for effective delivery of nursing intervention, including integrity of in-tervention, compliance of participants, and randomization of grouping. Conclusions The above strategies should be insisted to design and carry out nursing intervention research, in order to make the intervention applicable, standardized and easy to generalize in clinic.

Objective To investigate the permeability changes of prostate cancer cells membrane under low intensity ultrasound in vitro.Methods The culture of monolayer adherent LNCaP prostate cancer cells in six-well plate was exposed to continuous ultrasound at frequency of 1 MHz.The cells membrane permeability (stained with Calcein)and cells viability(stained with PI)were evaluated by fluorescent microscope (FM) and cells morphological changes were evaluated by scanning electron microscope (SEM) under ultrasound with acoustic intensity of 160 mW/cm2 for 5 s.The rate of cells with increased cells membrane permeability as function of acoustic intensity (80 mW/cm2,120 mW/cm2 and 160 mW/cm2,for 5 s) and exposure duration (5 s,10 s and 15 s,acoustic intensity of 120 mW/cm2) was evaluated by flow cytometry.ResultsAfter low intensity of ultrasound,the cells with increased cell membrane permeability could be clearly shown with Calcein uptake under FM while no cell showed Calcein uptake in the control group.The SEM showed less microvilli on the cells after low intensity of ultrasound exposure and few cells showed holes on the cell membrane.The rate of cells with increased membrane permeability increased with acoustic intensity and exposure duration.Conclusion Low intensity ultrasound alone could increase membrane permeability of prostate cancer cells and cells with increased membrane permeability showed surface plane,uncommon holes on the cells membrane.The rate of cells with increased membrane permeability positively correlated with acoustic intensity and exposure duration.

Animals ; Cell Division ; Drosophila melanogaster ; cytology ; enzymology ; Female ; Stem Cells ; cytology ; enzymology ; Ubiquitin-Protein Ligases ; metabolism

Humans ; Lymphoma, B-Cell ; complications ; pathology ; Lymphoma, Non-Hodgkin ; complications ; pathology ; Male ; Mesentery ; Middle Aged ; Peritoneal Neoplasms ; complications ; pathology ; Renal Insufficiency ; etiology

0.1 improved significantly, while the eyesights of the other patients improved slightly or not at all. In the 53 cases of mass diseases,45 cases (84.9 %) required complete removal whereas 8 cases required bulk removal. No cases of sunken eyeball was found. Snuffle was improved in all cases. Most symptoms disappeared and no optic nerve injury resulted after the tumors in the orbital apex were removed. CONCLUSION Selecting the proper operative approach is important to the uncovering of the operative area. The use of navigation systems and endoscope could increase the rate of complete removals,result in fewer injuries of vessels and nerves,and avoid facial incision.

Animals ; Cell Adhesion ; Cell Movement ; Colorectal Neoplasms ; metabolism ; pathology ; Drug Delivery Systems ; Epithelial-Mesenchymal Transition ; Humans ; Lung Neoplasms ; metabolism ; pathology ; Neoplasm Invasiveness ; Neoplasms ; metabolism ; pathology ; Neural Cell Adhesion Molecule L1 ; chemistry ; metabolism ; Pancreatic Neoplasms ; metabolism ; pathology

Hand ; Humans ; Reference Standards ; Vibration

Nanotubes, Carbon ; adverse effects ; chemistry

Cerebellar Neoplasms ; genetics ; DNA Repair ; Humans ; Medulloblastoma ; genetics

Adenoma, Liver Cell ; classification ; Humans ; Liver Neoplasms ; classification