Carcinoma, Pancreatic Ductal ; classification ; pathology ; Cystadenocarcinoma ; classification ; pathology ; Cystadenoma ; classification ; pathology ; Humans ; Neuroendocrine Tumors ; classification ; pathology ; Pancreatic Neoplasms ; classification ; pathology ; Precancerous Conditions ; classification ; pathology ; World Health Organization

Sixty mongrel dogs were divided into three groups of twenty dogs. One group of twenty dogs underwent placement of a rigid reconstruction plate (2.7mm thickness of plates and 3.0mm diameter of screws, Richards plating system, stainless-steel) and labeled normal mandibles stress shielded (NMSS) group. Another group of twenty dogsundeuuent cancellous cellular bone grafts of 3.5cm in length and a rigid reconstruction plate. In this group the plates were left in place until the time of sacrifice(1460 days) The group was labeled as a bone grafted mandibles stress shielded (BGSS). Ten dogs of each group were sacrificed at day 60. Another ten dogs of cach group were sacrificed at day 1460. In addition, all intitial resection specimens were processed for histomorphometry on trabecular bone area(TBA) as a normal non-stress shielded reference value of day-0 control (NMNSS) group. The histomorphometric results are as follows. Average percentage of TBA at day 0 control in NMNSS group was 44+/-5%. Average percentage of TBA in NMNSS group at 60 days was 42+/-6% , and that at 1460days was 42+/-4%. Average percentage of TBA in NMSS group at 60days was 47+/-6%, and that at 1460days was 44+/-4%, while average percentage of TBA at day 0 control was 44+/-5% (pinot available). Average percentage of TBA in BGNSS group at 60 days was 67+/-4, and that at 1460 days was 65+/-4%, while average percentage of TBA in day o control was 44+/-5%. BGNSS group shows, once each mandible was bone grafted at 60 days, that bone density was increased due to the high cellular bone grains. But after 1460 days there are little significant change, and that they are stable for four years(p<.001). Average percentage of TBA in BGSS group at 60 days was O+/-6, and that at 1460 days was 66+/-4% , while average percentage of TBA at day O control was 44+/-5%. BGSS group with the plate left in place for 4 years also shows the enhanced bone trabecular percentage at 60 days due to the high cellular bone grafts, but after 60 days until 4 years still little significant change(p<.001). The result data indicates the stress shielding from the rigid reconstruction plate on the mandible is not valid. It is suggested that clinicians do not need to remove reconstruction plates for fear of stress shielding.
Animals ; Bone Density ; Edible Grain ; Dogs* ; Mandible ; Reference Values ; Transplants*

Adult ; Antigens, CD ; metabolism ; Antigens, Differentiation, Myelomonocytic ; metabolism ; Biopsy ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; Lung ; diagnostic imaging ; metabolism ; pathology ; Lung Diseases, Interstitial ; metabolism ; pathology ; Silicosis ; diagnostic imaging ; metabolism ; pathology ; Tomography, X-Ray Computed ; Vimentin ; metabolism

Biomedical Research ; trends ; Female ; Humans ; Hydatidiform Mole ; diagnosis ; genetics ; Pregnancy ; Uterine Neoplasms ; diagnosis

Animals ; Herbicides ; poisoning ; Humans ; Paraquat ; poisoning

OBJECTIVETo compare the differences in the clinical efficacy on post-stroke speech disorder between scalp electric acupuncture (EA) under anatomic orientation combined with rehabilitation training and simple rehabilitation training.

METHODSSixty patients of post-stroke speech apraxia were randomized into an observation group and a control group, 30 cases in each one. In the observation group, under anatomic orientation, the scalp EA was adopted to the dominant hemisphere Broca area on the left cerebrum. Additionally, the speech rehabilitation training was combined. In the control group, the speech rehabilitation training was simply,used. The treatment lasted for 4 weeks totally. The speech movement program module in the psychological language assessment and treatment system of Chinese aphasia was used for the evident of efficacy assessment. The scores of counting, singing scale, repeating phonetic alphabet, repeating monosyllable and repeating disyllable were observed in the patients of the two groups. The assessment was done separately on the day of grouping and 4 weeks after treatment.

RESULTSIn 4 weeks of treatment, the scores of counting, singing scale, repeating phonetic alphabet, repeating monosyllable and repeating disyllable were all improved as compared with those before treatment in the two groups (all P<0. 001). The results in the observation group were better than those in the control group (all P< 0. 05). The total effective rate was 100. 0% (30/30) in the observation group, superior apparently to 53. 3% (16/30) in the control group (P<0. 001).

CONCLUSIONThe scalp EA under anatomic orientation combined with' speech rehabilitation training obviously improves speech apraxia in stroke patients so that the speech disorder cani be relieved. The efficacy is better than that in simple rehabilitation training.

Acupuncture Points ; Adolescent ; Adult ; Aged ; Apraxias ; etiology ; physiopathology ; rehabilitation ; therapy ; Electroacupuncture ; Female ; Humans ; Language ; Male ; Middle Aged ; Speech Disorders ; physiopathology ; rehabilitation ; therapy ; Speech Therapy ; Stroke ; complications ; Young Adult

PURPOSE: The authors investigated the ability of cardiac blood pool clearance rates(CBCR) of 99mTc-DiSiDA in the measure merit of functioning hepatocyte mass. MATERIALS AND METHODS: We measured the volume of Iobectomized liver after completion of postoperative scanning with CBCR of 99rnTc-DISIDA in 5 rabbits who the functional hepatic Iobectomy performed by ligation of hepatic artery, portal vein and biliary tracts. Regarding the measurement of CBCR of 99mTc-DISIDA, we set the time which was decreased to the half of the clearance amount of the cardiac radioactivity by hepatic extraction of 99mTc-DISIDA at the point of 50 sec after the renal peak of the radioactivity to prevent confusing with the blood dilution of the radioactivity, that have called DI-K50. RESULTS: The results were followed that the volumes of the functional hepatic Iobectomy in 5 rabbits were 25%, 25%, 41%, 52%, 75% and the residual functioning hepatocyte masses measured by CBCR of 99rnTc-DISIDA were preserved to 75. 1%, 70. 8%, 63. 0%, 52. 2%, 30. 8% respectively. CONCLUSION: we made decision that CBCR of 99rnTc-DISlDA was useful to evaluate the functioning hepatocyte mass.
Biliary Tract ; Hepatic Artery ; Hepatocytes* ; Ligation ; Liver ; Portal Vein ; Rabbits ; Radioactivity ; Technetium Tc 99m Disofenin*

Several investigators have attempted to clarify th well-known phenomenon of anergy in lepromatous leprosy during past two decades, utilizing various methods of immunologic assessrvent, including response to skin test antigens, active skin sensitization with strong allergens, skin homograft survival rate, imrnunopathology of lymphnodes, in vitro blastogenic response by antigens or mitogens of lymphocytes, lymphokine production in vitro and measurement of peripheral T and B cell ratio. Howcver, there is no general agreement as to the cellular irnmunologic status of leprosy patients b tween various investigators. The present study was undertaken to evaluate the ability to mount cutaneous hypersensitivity reactions to various skin test antigens and to investigate active sensitization with DViCB in patients with leprosy. Ten polar lepromatous (LL) and 12 polar tuberculoid (TT) p-tients who have been treated at Department of Dermatology, National Iviedical Center and Seoul Nationa,l University Hospital were the subjects. The subjects have rcceived regular antileprosy chemotherapy with DDS and the average duration of treatment in LL and TT groups was 6. 2 and 4. 7 years, respectively. The control group included 10 healthy physicians and nurs-s. Skin test antigens includ=d lepromin (1 x10' bacilli,ml'), PPD (Parke-Davis 5ppJ/0.1ml), SK-SD (Lederle, 40 u SK and 10 u SD/0.1 ml), Candidin (Hollister stier Lab 1: 1000 dilution) and DNCB aceton solution in the concentrations of 1000ug,/0.1ml for sensitization and 100ug/0.1ml for challenge, respcctively. Skin reactions were read 48 hours after intraderrnal injection of 0.1 rnl of each antigen anci th.' metho4 of DNCB sensitization was same as described elsewhere. The result showed that in polar lepromatous leprosy patients, the skin reactivity to various antigens were generally decroased, as cornpared to both th healthy control group and polar tuberculoicl patients, especially to lepromin, PPD and I')NCB sensitization (p<0.05, respectively). We concluded thxt lepromatous leprosy patients were especially unresponsive to mycobacterial antigcns(lepromin and PPD) and to newly administered antigen (DNCB) and tbe possible mechanism was discussed.
Allergens ; Allografts ; Antigens ; Dermatology ; Dinitrochlorobenzene ; Drug Therapy ; Humans ; Hypersensitivity* ; Lepromin ; Leprosy* ; Leprosy, Lepromatous ; Lymphocytes ; Mitogens ; Research Personnel ; Seoul ; Skin Tests* ; Skin* ; Survival Rate

Acanthosis Nigricans ; pathology ; Adolescent ; Adult ; Diagnosis, Differential ; Erythrokeratodermia Variabilis ; pathology ; Female ; Humans ; Keratoderma, Palmoplantar ; pathology ; Male ; Middle Aged ; Retrospective Studies ; Young Adult