1.Delayed-onset focal dystonia after stroke.
Young Chul CHOI ; Myung Sik LEE ; Il Saing CHOI
Yonsei Medical Journal 1993;34(4):391-396
The delayed-onset focal or segmental dystonia is a rare sequelae of cerebrovascular disease. The responsible lesion sites for the dystonia are variable and the pathogenesis is uncertain. This study reports three patients with delayed-onset focal dystonia as a complication of stroke. The interval between hypoxic insult and onset of dystonia were varied from 1 month to 1 year. Two adults and one child had focal lesions at the contralateral basal ganglia. The interval between the brain damage and dystonia did not appear to be related to the age at the time of hypoxic injury. The site of lesions may serve as an important factor in the pathogenesis.
Case Report
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Cerebrovascular Disorders/*complications/diagnosis
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Dystonia/*etiology/physiopathology
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Foot/physiopathology
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Hand/physiopathology
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Human
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Magnetic Resonance Imaging
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Male
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Middle Age
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Tomography, X-Ray Computed
2.Noxious electrical stimulation of the pelvic floor and vagina induces transient voiding dysfunction in a rabbit survival model of pelvic floor dystonia.
Amy D DOBBERFUHL ; Sara SPETTEL ; Catherine SCHULER ; Robert M LEVIN ; Andrew H DUBIN ; Elise J B DE
Korean Journal of Urology 2015;56(12):837-844
PURPOSE: Existing data supports a relationship between pelvic floor dysfunction and lower urinary tract symptoms. We developed a survival model of pelvic floor dysfunction in the rabbit and evaluated cystometric (CMG), electromyographic (EMG) and ambulatory voiding behavior. MATERIALS AND METHODS: Twelve female adult virgin rabbits were housed in metabolic cages to record voiding and defecation. Anesthetized CMG/EMG was performed before and after treatment animals (n=9) received bilateral tetanizing needle stimulation to the pubococcygeous (PC) muscle and controls (n=3) sham needle placement. After 7 days all animals were subjected to tetanizing transvaginal stimulation and CMG/EMG. After 5 days a final CMG/EMG was performed. RESULTS: Of rabbits that underwent needle stimulation 7 of 9 (78%) demonstrated dysfunctional CMG micturition contractions versus 6 of 12 (50%) after transvaginal stimulation. Needle stimulation of the PC musculature resulted in significant changes in: basal CMG pressure, precontraction pressure change, contraction pressure, interval between contractions and postvoid residual; with time to 3rd contraction increased from 38 to 53 minutes (p=0.008 vs. prestimulation). Vaginal noxious stimulation resulted in significant changes in: basal CMG pressure and interval between contractions; with time to 3rd contraction increased from 37 to 46 minutes (p=0.008 vs. prestimulation). Changes in cage parameters were primarily seen after direct needle stimulation. CONCLUSIONS: In a majority of animals, tetanizing electrical stimulation of the rabbit pelvic floor resulted in voiding changes suggestive of pelvic floor dysfunction as characterized by a larger bladder capacity, longer interval between contractions and prolonged contraction duration.
Animals
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Disease Models, Animal
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Dystonia/*etiology
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Electric Stimulation/adverse effects/methods
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Electromyography/methods
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Female
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Muscle Contraction/physiology
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Pelvic Floor/*physiopathology
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Pelvic Floor Disorders/*complications/physiopathology
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Rabbits
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Urinary Bladder/physiopathology
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Urinary Retention/*etiology
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Urination/physiology
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Urine
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Vagina/*physiopathology