1.Dysideanones F-G and dysiherbols D-E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara.
Hong-Yan LIU ; Mi ZHOU ; Ru-Yi SHANG ; Li-Li HONG ; Guang-Hui WANG ; Wen-Jing TIAN ; Wei-Hua JIAO ; Hai-Feng CHEN ; Hou-Wen LIN
Chinese Journal of Natural Medicines (English Ed.) 2022;20(2):148-154
Four new sesquiterpene quinone meroterpenoids, dysideanones F-G (1-2) and dysiherbols D-E (3-4), were isolated from the marine sponge Dysidea avara collected from the South China Sea. The new structures were elucidated by extensive analysis of spectroscopic data including HR-MS and 1D and 2D NMR spectra, and their absolute configurations were assigned by single-crystal X-ray diffraction and ECD calculations. Anti-inflammatory evaluation showed that dysiherbols D-E (3-4) exhibited moderate inhibitory activity on TNF-α-induced NF-κB activation in human HEK-293T cells with IC50 values of 10.2 and 8.6 μmol·L-1, respectively.
Animals
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Dysidea/chemistry*
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Porifera
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Quinones/pharmacology*
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Sesquiterpenes/pharmacology*
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Skeleton
Result Analysis
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