1.Complete hydatidiform mole with live fetus: A report of two cases.
Philippine Journal of Obstetrics and Gynecology 2000;24(3):105-110
Two cases of complete hydatidiform mole with coexistent live fetus are presented with special considerations on diagnosis and management. Incidence in the west is 1:10,000 to 1:100,000 pregnancies. These cases are only 2 of the 3 cases diagnosed in the Philippines. Diagnosis can be made by morphology, immunostaining and cytogenetics. Prognosis is unpredictable. Clinical symptoms vary from an aggressive disease requiring termination of pregnancy becuase of high risk of persistent trophoblastic disease or a more stable group that may reach viability. Clinical management should be decided on an individual basis, taking into account the risk to the mother of continuing the pregnancy and the parents wishes. (Author)
Human ; Female ; Adult ; Hydatidiform Mole ; Gestational Trophoblastic Disease ; Mothers ; Parents ; Fetus ; Prognosis
2.Predictive factors for the successful implantation and live birth after Euploid Blastocyst Transfer: A single center study
Christine Joyce P. Maningas-Omolida ; Debbie Guani Dy-Meguizo ; Virgilio M. Novero Jr.
Philippine Journal of Reproductive Endocrinology and Infertility 2021;18(2):53-61
Background:
Pre-implantation Genetic Testing for Aneuploidy (PGT-A) has enabled IVF
specialists to screen embryos for abnormalities in chromosome number and structure.
Subsequently, healthy embryos are selected for transfer, decreasing the rate of spontaneous
miscarriages and improving pregnancy outcomes. In spite of this, almost only half of the PGTdetermined euploid embryos result in a pregnancy.
Objective:
This study aimed to determine what other factors among euploid embryo transfers
will have an association with successful implantation and live birth.
Methods:
This study retrospectively analyzed 159 IVF-PGS cycles performed in CARMI SLMCGC from January 2017 to December 2019. Of these, a total of 231 euploid embryos (86 single
embryo transfers and 73 double embryo transfers) were assessed. The relationship of eight
predictive variables (maternal age, maternal BMI, etiology of infertility, history of failed IVF,
blastocyst expansion stage, ICM grade, TE grade and endometrial thickness on transfer) with
regard to the outcome of successful implantation and live birth among single or double euploid
blastocyst transfers were determined via logistic regression analysis.
Results:
Overall, the implantation rate was significantly lower when using B-grade ICM or
C-grade ICM blastocysts as compared to A-grade ICM blastocysts (OR 0.54, 95% CI 0.356-
0.815, p = 0.003). With regard to live birth rate, the success of transfer is statistically lower
when using a B-grade or C-grade ICM blastocysts as compared to A-grade ICM blastocysts (OR
0.55, CI 0.354-0.863, p = 0.009). Other predictive factors such as maternal age, maternal BMI,
etiology of infertility, number of previous IVF, blastocyst expansion stage, trophectoderm grade
and endometrial thickness had no apparent effect on the outcome of implantation and live birth.
Conclusion
Present study results suggest that only the ICM grade of euploid blastocysts
correlates with implantation and live birth in IVF-FET cycles. Therefore, the selection of euploid
blastocysts based on the presence of a higher grade ICM is the most predictive factor that
determines success among those undergoing IVF with PGT-A.
Live Birth
;
Genetic Testing
3.Laboratory outcomes of rescue in-vitro maturation in women with polycystic ovary syndrome, diminished and normal ovarian reserve: A single center study
Michelle M. Lipana ; Virgilio M. Novero Jr. ; Debbie Guani Dy-Meguizo
Philippine Journal of Reproductive Endocrinology and Infertility 2024;21(2):47-58
BACKGROUND
In-vitro maturation (IVM) is utilized to avoid ovarian hyperstimulation syndrome and decrease the cost of IVF. However, there are different opinions regarding its utility. We evaluated outcomes of rescue IVM in polycystic ovary syndrome, diminished and normal ovarian reserve.
METHODSThis retrospective cohort involves 615 immature oocytes retrieved from 221 IVF cycles. Outcomes of in-vitro matured oocytes were compared to sibling in-vivo mature oocytes. Association between stimulation an study trigger protocol were analyzed.
RESULTSLaboratory outcomes of Rescue-IVM (R-IVM) matured oocytes showed no statistically significant difference among groups. In-vivo mature oocytes showed a significantly higher fertilization rate and blastocyst rate (p < 0.0001) compared to in-vitro matured oocytes. Progestin primed protocol and combination/dual trigger had significantly higher maturation rates.
CONCLUSIONImmature oocytes undergoing R-IVM can potentially undergo maturation, fertilization and even developed to blastocyst stage. However, given the low efficiency of development to blastocyst stage, higher power studies are needed to evaluate its practical use.
Human ; Female ; Polycystic Ovary Syndrome