2.Pulmonary endarterectomy and balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: The Singapore experience.
Wen RUAN ; Jonathan YAP ; Kevin QUAH ; Foong Koon CHEAH ; Ghee Chee PHUA ; Duu Wen SEWA ; Aidila Binte ISMAIL ; Alicia CHIA ; David JENKINS ; Ju Le TAN ; Victor CHAO ; Soo Teik LIM
Annals of the Academy of Medicine, Singapore 2021;50(3):270-273
3.Rapid training of non-intensivists using an online critical care course during COVID-19.
Hui Zhong CHAI ; Constance Wei Shan TEO ; Lit Soo NG ; Sandra Li Yan HUI ; Duu Wen SEWA ; Ghee Chee PHUA ; Jolin WONG ; Carrie Kah Lai LEONG ; Ken Junyang GOH
Annals of the Academy of Medicine, Singapore 2021;50(6):503-507
5.Clinical Updates on the Diagnosis and Management of Chronic Thromboembolic Pulmonary Hypertension.
Wen RUAN ; Jonathan Jl YAP ; Kevin Kh QUAH ; Foong Koon CHEAH ; Ghee Chee PHUA ; Duu Wen SEWA ; Aidila Binte ISMAIL ; Alicia Xf CHIA ; David JENKINS ; Ju Le TAN ; Victor Tt CHAO ; Soo Teik LIM
Annals of the Academy of Medicine, Singapore 2020;49(5):320-330
INTRODUCTION:
Chronic thromboembolic pulmonary hypertension (CTEPH) is a known sequela after acute pulmonary embolism (PE). It is a debilitating disease, and potentially fatal if left untreated. This review provides a clinically relevant overview of the disease and discusses the usefulness and limitations of the various investigational and treatment options.
METHODS:
A PubMed search on articles relevant to PE, pulmonary hypertension, CTEPH, pulmonary endarterectomy, and balloon pulmonary angioplasty were performed. A total of 68 articles were found to be relevant and were reviewed.
RESULTS:
CTEPH occurs as a result of non-resolution of thrombotic material, with subsequent fibrosis and scarring of the pulmonary arteries. Risk factors have been identified, but the underlying mechanisms have yet to be fully elucidated. The cardinal symptom of CTEPH is dyspnoea on exertion, but the diagnosis is often challenging due to lack of awareness. The ventilation/perfusion scan is recommended for screening for CTEPH, with other modalities (eg. dual energy computed tomography pulmonary angiography) also being utilised in expert centres. Conventional pulmonary angiography with right heart catheterisation is important in the final diagnosis of CTEPH.
CONCLUSION
Operability assessment by a multidisciplinary team is crucial for the management of CTEPH, as pulmonary endarterectomy (PEA) remains the guideline recommended treatment and has the best chance of cure. For inoperable patients or those with residual disease post-PEA, medical therapy or balloon pulmonary angioplasty are potential treatment options.
6.Association between lung compliance phenotypes and mortality in COVID-19 patients with acute respiratory distress syndrome.
Ser Hon PUAH ; Matthew Edward COVE ; Jason PHUA ; Amit KANSAL ; Jonathen VENKATACHALAM ; Vui Kian HO ; Duu Wen SEWA ; Roshni Sadashiv GOKHALE ; Mei Fong LIEW ; Benjamin Choon Heng HO ; Jensen Jiansheng NG ; John A ABISHEGANADEN ; Yee Sin LEO ; Barnaby Edward YOUNG ; David Chien LYE ; Tsin Wen YEO
Annals of the Academy of Medicine, Singapore 2021;50(9):686-694
INTRODUCTION:
Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with a high mortality rate, though outcomes of the different lung compliance phenotypes are unclear. We aimed to measure lung compliance and examine other factors associated with mortality in COVID-19 patients with ARDS.
METHODS:
Adult patients with COVID-19 ARDS who required invasive mechanical ventilation at 8 hospitals in Singapore were prospectively enrolled. Factors associated with both mortality and differences between high (<40mL/cm H
RESULTS:
A total of 102 patients with COVID-19 who required invasive mechanical ventilation were analysed; 15 (14.7%) did not survive. Non-survivors were older (median 70 years, interquartile range [IQR] 67-75 versus median 61 years, IQR 52-66;
CONCLUSION
COVID-19 ARDS patients with higher compliance on the day of intubation and a longitudinal decrease over time had a higher risk of death.
COVID-19
;
Humans
;
Lung Compliance
;
Phenotype
;
Respiratory Distress Syndrome/therapy*
;
SARS-CoV-2
7.Predictors and outcomes of high-flow nasal cannula failure following extubation: A multicentre observational study.
Amit KANSAL ; Shekhar DHANVIJAY ; Andrew LI ; Jason PHUA ; Matthew Edward COVE ; Wei Jun Dan ONG ; Ser Hon PUAH ; Vicky NG ; Qiao Li TAN ; Julipie Sumampong MANALANSAN ; Michael Sharey Nocon ZAMORA ; Michael Camba VIDANES ; Juliet Tolentino SAHAGUN ; Juvel TACULOD ; Addy Yong Hui TAN ; Chee Kiang TAY ; Yew Woon CHIA ; Duu Wen SEWA ; Meiying CHEW ; Sennen J W LEW ; Shirley GOH ; Jonathan Jit Ern TAN ; Kollengode RAMANATHAN ; Amartya MUKHOPADHYAY ; Kay Choong SEE
Annals of the Academy of Medicine, Singapore 2021;50(6):467-473
INTRODUCTION:
Despite adhering to criteria for extubation, up to 20% of intensive care patients require re-intubation, even with use of post-extubation high-flow nasal cannula (HFNC). This study aims to identify independent predictors and outcomes of extubation failure in patients who failed post-extubation HFNC.
METHODS:
We conducted a multicentre observational study involving 9 adult intensive care units (ICUs) across 5 public hospitals in Singapore. We included patients extubated to HFNC following spontaneous breathing trials. We compared patients who were successfully weaned off HFNC with those who failed HFNC (defined as re-intubation ≤7 days following extubation). Generalised additive logistic regression analysis was used to identify independent risk factors for failed HFNC.
RESULTS:
Among 244 patients (mean age: 63.92±15.51 years, 65.2% male, median APACHE II score 23.55±7.35), 41 (16.8%) failed HFNC; hypoxia, hypercapnia and excessive secretions were primary reasons. Stroke was an independent predictor of HFNC failure (odds ratio 2.48, 95% confidence interval 1.83-3.37). Failed HFNC, as compared to successful HFNC, was associated with increased median ICU length of stay (14 versus 7 days,
CONCLUSION
Post-extubation HFNC failure, especially in patients with stroke as a comorbidity, remains a clinical challenge and predicts poorer clinical outcomes. Our observational study highlights the need for future prospective trials to better identify patients at high risk of post-extubation HFNC failure.
Adult
;
Airway Extubation
;
Cannula
;
Critical Care
;
Female
;
Humans
;
Intensive Care Units
;
Male
;
Middle Aged
;
Respiratory Insufficiency/therapy*
;
Singapore/epidemiology*
8.Therapeutic temperature management (TTM): post-resuscitation care for adult cardiac arrest, with recommendations from the National TTM Workgroup.
Siew Hon Benjamin LEONG ; Enoch CHAN ; Benjamin Choon Heng HO ; Colin YEO ; Sennen LEW ; Duu Wen SEWA ; Shir Lynn LIM ; Chee Wan LEE ; Pow Li CHIA ; Tien Siang Eric LIM ; Eng Kiang LEE ; Marcus Eng Hock ONG
Singapore medical journal 2017;58(7):408-410
Therapeutic temperature management (TTM) was strongly recommended by the 2015 International Liaison Committee on Resuscitation as a component of post-resuscitation care. It has been known to be effective in improving the survival rate and neurologic functional outcome of patients after cardiac arrest. In an effort to increase local adoption of TTM as a standard of post-resuscitation care, this paper discusses and makes recommendations on the treatment for local providers.