1.Research Progress on the Role of HMGB1 in Regulating the Function of Osteoarthritis Chondrocytes
Xin QI ; Xiaogang ZHANG ; Haiyang YU ; Xin CHEN ; Wenbo AN ; Zhipeng WANG ; Duoxian WANG ; Pengfei LUO ; Yixin CHEN ; Jiaojiao MA ; Wei QI ; Ziyang HU ; Jianjun LIU
Medical Journal of Peking Union Medical College Hospital 2024;15(1):141-146
Osteoarthritis (OA) is a chronic degenerative joint disease whose main characteristic is the destruction of articular cartilage, causing pain and disability in patients and seriously affecting their quality of life. OA can be induced by a variety of causes, and pathological changes in articular cartilage are considered to be one of the key driving factors for the occurrence of OA. High mobility group box-1 protein (HMGB1), as a non-histone protein in eukaryotic cells, can participate in regulating the inflammation and apoptosis process of OA chondrocytes, thus leading to the occurrence of OA. This article reviews the research on the mechanism of HMGB1 in OA chondrocytes, with a view to providing new ideas for the clinical prevention and treatment of OA.
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