Immunoglobulin E (IgE) is important in pathogenesis of allergic asthma reaction. Thus, inhibiting the combination of IgE and receptors in the membrane of mastocytes and other effective cells is able to reduce the body responses with allergens and decrease symptoms of asthma attacks. Monoclonal antibodies (Omalizumab) are effective in inhibiting the combination of IgE and receptors. The use of monoclonal antibodies in asthma treatment opened a new strategy, and confirmed the important roles of immunoglobulins in pathogenesis of asthma
Antibodies, Monoclonal ; Therapeutics ; asthma

Introduction: Da Lat, a city at 1500m above sea level, the average temperature there is 180C, with warm weather from January to April and the rainy season lasting from May to December. Respiratory condition and seasonal allergy is commonplace among the population of this area. Objectives: This study aims to determine the prevalence of asthma and asthma-like symptoms in Da lat and to learn about the environmental influences, patient\u2019s attitudes toward diagnosis, treatment and general knowledge about asthma. Subjects and method: After an extensive publicity campaign by local television, the subjects were randomly selected for interviews. When asthma or asthma-like symptoms were identified, all parts of the questionnaire were completed and a more detailed visit was arranged with the patients, for clinical examination, spirometry and skin tests for important allergens. Results:9984 individuals were interviewed; of whom 243 were identified as having asthma or asthma-like symptoms, giving a prevalence of 2.4 percent. Average age was 48+/-27 years, age at the onset of asthma was 25+/-22 years; Hospitalization had been required in 18.3 percent of patients during 2003. Daily asthma treatment was used by only 17 percent of patients. 34 percent used inhalers and 6 percent used nebulisation. 52.3 percent had associated atopic features. With Polyvalent positive prick tests, but no one reacted to a pollen mixture. General knowledge about asthma was lacking. Conclusion: Results showed a low prevalence of asthma and asthma-like symptoms in Da Lat, the study highlights the need for further patient education and for preventive interventions for asthma in this region.
Prevalence ; bronchus asthma